Sesshomaru's mother was introduced in volume 47 at the end of chapter 466.

Sesshomaru's mother is also an inuyōkai (dog demon) like her deceased mate the Inutaisho and as such can transform into a giant dog demon as well as a more human appearance. Although Inu no Taishou sired a child with his human lover Izayoi, it remains uncertain as to whether or not the relationship with Sesshomaru's mother had ended.

Sesshomaru's mother holds the Meidō-Seki, which was given to her by the Inutaisho. He told her that if Sesshomaru were to come by to use it and "If you use Meidō-Seki Sesshomaru will be faced with great danger... However, you must not feel fear or sadness." This apparently is another of Inu no Taishou's tests for his sons.

In demeanor she seems similar to Sesshomaru, albeit with a certain playfulness, and probably influenced his initial attitude towards humans; observing Rin and Kohaku following Sesshomaru, she inquires casually if he is planning to eat them. Observing Sesshomaru's trial after activating the Meidō-Seki, she seems at best only casually concerned about the possibility of his death, and after he refuses the escape route she offers, she seems mildly offended, huffing, "Fine. Ignore your mother's kindness," and complaining that, unlike his father, he "completely lacks any charm."

[Though it cannot be noticed in English, the Japanese Manga clearly shows that Sesshomaru uses rude, loose language to his mother as if she were someone less than him.]