it's quite an active process, love


the dead don't love


and low thyroid


is part of the way


to being dead





this page is intended to be read in the context of the synergistic approach of the   compendium   and   biofilm/microbiome carbohydrate diet


iodine supplementation needs to be approached with caution because of potential thyroid and other autoimmunity issues and the need for mineral co-factors


there is no single modality for supplementing iodine and the content of this page needs to be utilised with  Q&A  on the  who knows  message board


eileen puts a drop or two or three  (2 or 3 in my case when i do this)  of  iodine tincture  on the gumward inside of the lower or upper lip or around abit futher into the cheek once every say 3, 4 or 5 days and that seems to work quite well


you can suck the saliva from the area first and hold the lip of the teeth afterwards off the teeth, maybe best done in the morning, but no later than five hours before bed to get past the intial 4? hour innervation stage !


you have to lie down to do that on the upper inside lip, i think it's quite important to rotate the application sites and the upper jaw gives quite abit more spread


it's not a lot of iodine and seems to be uptaken by the thyroid quite well !


if you were ever faced with inhaling or ingesting radioactive iodine without warning, e.g. a dirty bomb or nuclear reactor had exploded that could affect you, then this would be the way get non radioactive iodine to your thyroid as quickly as possible so it holds the radioactive iodine out !


however, pregnant and breast feeding mothers need to be cautious of excess iodine intake as  per


this  study  says that despite mandatory iodized salt in bread in australia, pregnant women still require extra iodine !


tincture formulations vary from say .1 to 2.5 mg per drop, also drop sizes vary and are largest for a horizontally held dropper and least for vertically held droppers !


the drop or drops do affect the membrane on the inside lip, making it feel rough/unusual for several hours or 24 hours if you suck the saliva dry in the drop area before applying, so i think it pays to try and not hit the same area each time, try different spots, say left , right and middle of the lip and also inside the cheek seems to work quite well !


i am abit concerned about potential mutagenicity of the alcohol on a mucous membrane like that, i think it's a question of how often it is done and wether it's placed in different spot each time, however it does work very well and seems to be efficiently uptaken into the thyroid directly !


rather than put the iodine on the front gums/inside front lips, on average about once every 8 days i will spread say ˝ to 1 ml of tincture onto each of my under-forearms and arms which i have cleaned and exfoliated first !


i do this because i need the ability of this slow release iodine to keep my blood thin since i seems to get thick blood which makes me migrainey ! : o)







iodine for dummies


iodine tincture, what i take, and general discussion


fukushima


pointers and use


iodine and skin rashes, upper limits to oral use


the dangers of too little or too much iodine


iodine and skin d/vitamin d define a different space


iodine and teeth


i don't think the thyroid ever really recovers once knackered


the problems with medical thyroid hormones and biopsies


ultrasound revealing rough texture on the thyroid


iodine cures ovarian cysts, lack of iodine can cause them


higher saturated fat in the diet needs more iodine


general discussion and skin application


the choroid plexus, ciliary body, alzheimers, amd, glaucoma and iodine


toxins in fish interfering with thyroid processing enzymes


e. coli initiating an autoimmune response against the thyroid


undigested food particles getting across a leaky gut create autoimmune issues


iodine concentrates in the gallbladder


iodine dosing for gastric mucosa and antioxidant effect


chlorine and iodine don't mix


the thyroid and viruses


eating animal thyroids


selenium and iodine need to be in ratio


calcium is a goitrogen


mechanisms of chemical injury of thyroid gland


bisphenol A suppresses the transcription of thyroid hormone regulated genes


multinodular goiter an antibody issue?


iodine message board posts


david derry


trialing iodine with povidine iodine


frequent dosing of povidine iodine displaces radioactive iodine from the thyroid


does iodide in the gastric mucosa have an ancient antioxidant role?


human genome shaped around iodine


aging, damaged dna accumulation, growth hormone depression


work in progress







IODINE FOR DUMMIES




breastfeeding really depletes the mother of iodine and it is just poured into breast milk if available


interestingly the human fetus does not highly concentrate iodide relative to maternal iodide levels, unlike some other species like the rabbit, guinea pig, and sheep


this means that the breast feeding infant is very dependent on the mother for iodine


warning :  high dose iodine protocols (12.5mg daily in this  study! ) taken while pregnant or breast feeding will cause congenital hypothyroidism in the infant !   summary


_____________________



children born to mothers with mild to moderate iodine deficiency (living in iodine deficient areas) have attention deficit, anxiety-depressive disorders and asthenic symptoms as well as lower intelligence


    russian study               italian study


_____________________



“In a randomized, placebo-controlled, double-blind study involving 184 mildly iodine-deficient children, aged 10-13 years old, results indicate that iodine supplementation may improve cognition.


The children were randomized to receive a daily tablet containing either 150 microg iodine or placebo for 28 weeks. Cognitive performance was evaluated at intervention end.


Children in the iodine group showed significant improved scores in picture concepts and matrix reasoning, compared with children in the placebo group.


Thus, the authors of this  study  conclude, “Iodine supplementation improved perceptual reasoning in mildly iodine-deficient children and suggests that mild iodine deficiency could prevent children from attaining their full intellectual potential”


__________________



“For pregnant women who have a marginal iodine nutrition status, the disruption of the thyroid due to exposure to organochlorines could induce iodine deficiency and result in negative effects on the brain of the developing fetus.”


from “the interaction of agricultural pesticides and marginal iodine nutrition status as a cause of autism spectrum disorders”  letter


__________________



once people go hypothyroid they lose all intitiative and thinking ability


if you don't have enough t4 in your brain and can't convert enought t4 to t3 through the deiodinases within the brain, you become dull witted


what i am understanding more and more, is that thyroid problems make people just plain thick, the effect of thyroid hormones can be very compartmentalised and if you don't have adequate t4 in the brain and can't convert it to t3 adequately there, the brain just doesn't work


hypothyroidal can complex as both hyper from running on adrenaline, and hypo from low thyroid action, sorta cfs with bursts of energy


__________________



iodine supplementation really improves the intelligence in a slow incremental way


a high fat diet needs a lot of iodine (vegetable oils are a fat), the fat seems to soak iodine up


nutritionalists really don't get the basic which is that fats blot up iodine and need more iodine, and more iodine needs more cofactor minerals which was what traditional diets provided through the incorporation of offal


the whole anti-fat bias of western medical advice is in fact a somewhat useful response to this iodine fat absorption problem, but way inferior to the compendium™ and bcd™


iodine promotes sweating, with higher iodine you will sweat a lot and if you are very short of it you will not sweat much


in fact sweating too easily is one of the less pleasant side effects of useful iodine supplementation and moisture in skin folds like the groin can exacerbate existing fungal/yeast/biofilm conditions like tinea cruris and candida albicans if you are not careful


a negative of iodine supplementation is that it tends to promote skin and possibly urethral biofilm conditions, presumably because the complex toxicity/nutritionality of iodine changes the flora, reducing good flora allowing a pathogenic component to get away


also possibly the lingual tonsils  (which are different from the tonsils usually removed by surgery)  which could make for throat soreness


people used to use iodine tincture for cuts, abrasions etc as an antiseptic in the old days and got a lot more iodine this way


in fact the simplest way to trial iodine is to get a tube of povidine iodine/betadine (sold as an antiseptic) from a pharmacy and put a tiny amount on the skin


because of it's high I2 and anti-autoimmune effect, it may pay to use povidine iodine occasionally in place of iodine tincture if you are applying/taking tincture regularly


povidine iodine is very flattening emotionally and seems to reduce autoimmunity


betadine seems to be very effective for killing deep infection in a cut, the snag is that it also breaks open the natural closure/self-stitching of the cut so perhaps is best applied initially and savlon used later?


even just one application of betadine to a partly healed cut can defeat your own natural healing closure and let it break open !


i made a deep cut on my wrist on the dorsal side of the hand below the thumb stupidly using some long handled shears at the same time as holding some sharp open secateurs with that dangerous curved blade !


in retrospect i feel the right time to apply betadine was immediately after the cut and then not again because it breaks down any newly formed connective tissue as the cut heals, which was quite slow in this case and maybe i had/have a bit of arthritic pain because of immune activity and circulation to the scapoid (area?) is not good in the first place !


i keep betadine in the fridge to reduce the evaporation of iodine, wether this is useful i don't know?


betadine would be very useful in warm humid climates with their ongoing infection problems !


i think that waterproof dressings in general are problematic and usually use the elastoplast breathable fabric type!


if you are taking/applying iodine, the methods bifurcate into KI (potassium iodide) for thyroid promotion, or KI + I2 (potassium iodide + iodine) for the addition of the receptor refurbishment factor of I2


neat or diluted lugols on the skin seems to pretty much give the KI thyroid hormone only promotion (see the 'general discussion and skin application'  section  on this page)


topical and oral iodine tincture seems to give more of I2


iodine is not a stand-alone mineral, it needs the synergy of the compendium minerals and other other supplements


u can get an alcohol iodine tincture from walmart or krogers (sold as an antiseptic) in the usa; or from a pharmacy in the uk or australasia, though they might have to order it in for you (gold cross brand in australia, or a pharmacist can make it up for you, it's a well known formulation)


no prescription is needed


________________



the figures below apply to the australian  gold cross  brand   iodine tincture  containing 25mg/ml of iodine and 25mg/ml of potassium iodide


25mg/ml iodine + (19mg/ml of iodine in 25mg/ml of KI) = 44mg/ml


[ 25mg/ml potassium iodide where the molar mass of KI = 166 grams/mole, I = 127 grams/mole, K=39 grams/mole, so the amount of iodine in 25ml of KI is 127/166 x 25 = 19mg/ml ]


0.4 ml of iodine tincture = 16 drops (vertically held dropper which gives the smallest drop size), then 1 ml = 2.5 x 16 = 40 drops and there is 44 mg/ml of iodine so one drop has 1.1 mg of iodine


but only about 1 to 10% is absorbed


so if you rub 1 drop on your skin you you get about 50 micrograms of iodine (compared to a daily intake of about 350 micrograms?)


1000 micrograms (mcg) = 1 milligram (mg)


so just rub in a drop in to get 50 mcg of iodine which is a very safe level to experiment with imo and go upwards from there but i really would caution against too much, the high dose protocols promoted on message boards like yahoo iodine are being used as chemo or on top of thyroid meds and all the participants are out of their scones


it's not simply the mercury, lead or other enviromental toxins, but the stupid education system that poisons our brains


we do not know how to be real about solving problems


one little step at a time and see what the effect is


_______________________



Lisa found  "just one drop, two or three times a week"  has made her "feel clearer and much more energetic!"   "as long as I only do a small amount. It does improve my energy, if I do too much I start to get goiter and a sore throat. So now I know where the limit is, better not enough than too much."


I suspect she has leaky skin and is absorbing much more than 5%, as well as having unresolved thyroidal autoimmune issues, but the little iodine she is applying to her skin is very helpful to her and hopefully will help keep the female cluster of iodine deficiency cancers, fibrocystic and cystic conditions at bay (breast, ovarian, pcs)


if you are taking thyroid hormones you still need iodine


the most common thyroid cancer, 'papillary carcinoma' is promoted by high tsh, so low tsh is a good thyroid strategy that is met by the full compendium™ and BCD™


a good thyroid  pic  (opens in a new window)


selenium without iodine supplementation seems to reduce thyroid hormone levels because it passivates hydrogen peroxide in the thyroid hence there is less organification of iodine


conversely more iodine needs more selenium to offset the oxidating effect of more hydrogen peroxide in the thyroid


also more tyrosine (which can be got from the use of houstonni 'no fenol' enzyme - NOT from a tyrosine amino acid supplement) is needed because iodine binds to tyrosine


most areas of the world are selenium deficient, one of the unusual features of the usa is the often good levels of selenium in the diet which in fact compounds low thyroid problems in places like michigan since that area is iodine deficent and highish levels of selenium from say eating south dekota beef need higher levels of iodine


the soils of cereal grain growing areas in the usa are selenium replete


metabolic syndrome and digestive difficulties compound problems of selenium deficiency through malabsorbtion


i have written up the 'dual seleniums' in 'minerals i take' in the compendium index for the optimal way to supplement selenium


more tyrosine is best got from the houstonni 'no fenol' enzyme action, which just improves the uptake from food


the amino acid supplement tyrosine is very yeast/biofilm promoting like most amino acid supplements and not recommended


lithium and manganese as per the compendium™  are needed to dampen the hyper effect of larger amounts of iodine if you want to go from very low dose to moderate doses of say 2mg. they are also good for reducing hyperthyroid


the "one-a-day weight smart" weight loss multi with high inorganic chromium, no iodine, a biofilm promoting mix of minerals and a suspect mix of herbs, caused thyroid nodules and hasimotos in a woman i know of


auto-immunity problems from biofilm toxins and vaccines, and iodine and other trace mineral deficiencies are driving the huge current level of thyroid problems and cancer, which only look to increase


_______________________



bromine displaces iodine in the thyroid under conditions of iodine insufficiency


the half life of iodine and bromine in the rat thyroid is the same @ 110 hours/4.6 days  pmid: 9728485 note: rat thyroid function can be quite different from human


the half life of iodine in the human body (blood?) i have seen stated to be 7 hours with a standard deviation of two hours from an oral dose?


at enhanced intakes of bromine, iodine rather than chlorine is displaced from the thyroid  [pmid: 8909694]


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The average biological half-life of 131-I in the thyroids 26 of euthyroid (normal) subjects was found to be 66.1 ± 6.3 days which may be statistically significantly lower than the ICRP recommended value of 80 days. Nine hyperthyroid patients had a mean biological half-life of 38.2 ± 8.6 days and in three hypothyroid patients the corresponding value was 29.3 ± 8.8 days.


Thyroid 131-I uptake was measured in a conventional clinical fashion at the Ottawa Hospital Civic campus 24 h after oral administration of the radioiodine using a collimated thick sodium iodide detector placed over the neck arteriorly. Measured values were 0.144 ± 0.009, 0.314 ± 0.035 and 0.045 ± 0.010 of the administered dose in euthyroid, hyperthyroid and hypothyroid patients respectively. The euthyroid range at the hospital is 0.06 - 0.22. Uptake was significantly lower for the euthyroid group than the ICRP value of 0.3. The radioiodine retention in athyreotic (no thyroid) subjects followed a two compartment model with biological half-lives of 1.0 ± 0.2 days and 18.4 ± 1.1. days.


[Biological Half-life of Iodine in Adults with Intact Thyroid Function and in Athyreotic Persons - kramer et al]   here


my comment: this is in fact an iodine retention test


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t3 half life 5-8 hours?  study


half life of t4 about 6 days?


adequate selenium reduces the half life?


the compendium generally and skin d encourages thyroid hormone turnover?


2/3 life a more useful figure?


t3 2/3 life = 5 hours?     t4 2/3 life = 4˝ days?


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the decline of type 1 deiodinase (a selenium based enzyme) activities in the liver, kidney, and thyroid is one of the reasons for excess iodine damage and is offset by a suitable window selenium dose (aka the dual selenium protocol in the compendium minerals page)


type one and two deiodinases convert T4 to T3


"Intervention of selenium on injured type 1 deiodinase by excessive iodine in mice"


OBJECTIVE: To study the mechanism of the damage resulted from iodine excess and to seek suitable selenium intervention dosage. METHOD: 160 BALB/c mice were divided into eight groups, the normal control group, the excessive iodine group (drunk the water containing potassium iodate 3000 microg/L) and six selenium groups (drunk the water containing potassium iodate 3000 microg/L and selenium 0.1, 0.2, 0.3, 0.4, 0.5 and 0.75 mg/L). The type 1 deiodinase (D1) activities and the levels of mRNA in liver, kidney and thyroid were determined by RT-PCR. RESULTS: The mRNA levels of D1 restored to normal levels in all of the IS groups, while only 0.1-0.4 mg/L selenium supplement groups had normal activities of D1 in liver, kidney and thyroid. CONCLUSION: Decline of D1 activities in liver, kidney and thyroid seems to be one of the reasons of the damage and should be chosen for effective intervention. pmid: 18095564  september 2007


taking a mouse drinking about 1/2 a gram of water a day and weighting 20 grams, in the above study it is getting 1.5 micrograms of iodine a day which on a weight basis is equivalent to 4.2 milligrams for a 56 kilo human which is helpful in setting an upper limit to how much iodine can be taken and successfully remediated by selenium


the 0.1 selenium mg/l = 140 micrograms for a 56kg human
the 0.4 selenium mg/l = 560 micrograms for a 56kg human
the 0.5 selenium mg/l = 700 micrograms for a 56kg human


the compendium dual selenium protocol gives between 100 and 200 micrograms of selenomethionine and methylselenocysteine which shows an equivalence to the mouse data, albeit at a lower iodine/selenium set point which seems about right


the body biochemistry uses selenium in lockstep with iodine for the synthesis of deiodinases, selenoprotein P and selenoprotein W


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thyroid meds do not provide iodine for the bodies other iodine needs, probably because the thyroidal iodine is complexed into tyrosine and eliminated with the bodies usual turnover of hormones


so there is a need for iodine quite separate from thyroid hormones


goiter and hashimotos can be cancerous


the way the thyroid works is naturally cancerous from the generating of a very high rate of cell mutation during the making of thyroid hormones


radioactive iodine (RAI) for thyroid ablation is like a death sentence, the beta emitting I-131 used is the same as the radioactive fallout iodine from the nevada testing that caused so many thyorid cancers and other problems


it really disgusts me to see these thyroid cancer survivors 'selling' rai as harmless when they have so many ongoing health issues from it


realistic comments by a woman survivor of several abalations (100 mci's, 150 mCi's and 250 mCi's) - "RAI destroyed my digestive tract and I do not absorb things well."   "since RAI treatments I have had a struggle with my teeth and gums. They are sensitive, gums tender and teeth always throb."


the I-123 used for scanning is a gamma only emitter and is less harmful


you need to be proactive on your own behalf in terms of research and figuring things out and experimenting


if you don't do the work you are going to get medically crucified and believe me, they cue up to get on the cross


see my write up about RAI on  iatrogens


in terms of enviromentally sourced I-131 risk, there's a huge difference between wether you are iodine deficient or replete


iodine was the only general population intervention they did in the ukraine after chernobyl


practically it's about the only one you can do  : o )


if you are iodine deficient then I-131 is just going to be sucked up into the thyroid like a vacuum, if you are replete it's not !


good  page  on EPA (MCL 3 picoCuries per liter) and FDA (DIL 4700 picoCuries per liter)  I-131 limits


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thyroid problems destroy ones life in case you haven't got that yet, america is a wasteland of mentally stuffed middle aged women from thyroid problems


if you have low thryoid you are walking in a thunderstorm, the thyroid is incredibly complex and when it goes wrong it takes you and your brain down with it


mercury and biofilm toxins (lipopolysaccharide  studies) damage the thyroid and cause a reduction in the number of thryoid hormone receptors in cells over time


it is important to understand that thyroid receptor expression is downregulated with biofilm toxins like LPS, and the TSH feedback loop normalises on the reduced receptor expression, so the TSH will be within the reference range, but because the thyroid expression is reduced, so are cell energy levels and hence you can be hypothyroid with a "normal" TSH


antibodies eat the thyroid away as well if you develop antibodies to thyroid molecules




------------------------------




IODINE TINCTURE, WHAT I TAKE, AND GENERAL DISCUSSION



update 25/10/11 :


i am mostly placing two drops of iodine tincture inside the mouth on either the inside lower lip or lower gums or lower cheeks once every two or three or four days as this seems to give more energy so will see how this goes !


the alcohol in the tincture is the non toxic ethyl alcohol and a small amount like that you don't notice


i think the circulation takes it directly from the inside lip into the thyroid because it sure seems to work well !


topical iodine on the skin may still have a place !



what follows below is what i used to do, but still has relevance !


the protocol i do is apply .6ml - 1.6ml topical iodine tincture around about noon, every 2nd, 3rd, or 4th day  (see four sections  below)


you can sorta vary thick and thin skin to modulate the release and amount absorbed


putting it on the face seems to help put it in the brain which can help with migraine, but watch out for the alcohol vapour, closing the eyes seems to keep it out of the eyes and breathing with the lower jaw pulled in helps stop breathing the alcohol vapourising from the face in


the iodine tincture is is much better absorbed if the skin is washed or wiped by a damp paper towel and then left to dry before applying the iodine


the big secret with topical iodine tincture is when you apply it, i try to hit the peak of the natural thyroid morning cycle, about 11.40 am to 12.40 pm or midday


there may be utility applying it even as late as 1.20pm


i have applied iodine within half an hour of getting up in the morning, but something doesn't gell, maybe too much oxidative stress when the body is in an oxidative state or it messes with the natural thyroid cycle and is out of sync with it for that time of day


maybe iodine applied too early depresses the thryoid when levels are at a natural daily low?  messes the circadian rhythm?


also, once every now and then, from some time between late morning to no later than 4pm, i will swallow a drop of alcohol iodine tincture (2.5%) mixed with about 50 ml of water only, or vinegar and water, tho a female friend does the oral iodine daily


by the time i was half way through my 50 ml gold cross iodine tincture bottle, the evaporation of iodine is such that i needed at least two oral drops (only doing oral iodine very occasionally now - may 09)


it very significantly evaporates more as the bottle gets emptier with more airspace in, especially in warmer weather stored at room temperature !


oral iodine on an empty stomach may be anti-biofilmic against some biofilm bacteria including ureaplasma


however, keeping the bottle of iodine tincture in the fridge in summer greatly reduces the rate of iodine evaporation from the alcohol into the airspace in the bottle above the tincture


if you do this, you need to be sure that the bottle will not be accidently used for cooking or drunk from as it is a poison and could be fatal


fat soaks up iodine, if i am eating a lot of cream and fat, topical iodine is not enough, i have to supplement oral iodine as well


the issue with a high fat diet may not be atherosclerosis but its induction of an iodine deficiency


the body rids excess iodine by sweating so excess sweating is due to too much iodine, and conversely insufficient sweating is symptomatic of iodine deficiency


being headachy can be another sign of too much iodine


to take iodine with vinegar, one drop of alcohol iodine tincture (2.5%) is mixed with 1 -2 ml of white vinegar and 10 to 60 ml of warm (not cold at least), low solids, non-fluoridated water - reverse osmosis water is good for this, like the mount franklin brand in australia


the vinegar goes into the glass first, a drop of tincture is added and the contents of the glass then swirled, then the water added and swirled again and then the mixture swallowed


the iodine, vinegar and water mixture seem to sit better in the stomach than just iodine and water, though for travelling, just iodine and water is ok


even just one drop of iodine taken like this can cause hyper and poor sleep, which is in part why i hardly ever do this now


if you stop taking or applying iodine it loses its effect within several days


however this  research  (iodoacetic acid is a toxic water disinfection byproduct)  raises some questions about mixing iodine with vinegar/acetic acid since iodoacetic acid is a GAPDH inhibitor which impairs ATP production which increases oxidative stress !


i have no idea wether adding iodine to vinegar forms iodoacetic acid, however it may be a possibility !


i had a miraculous recovery of thyroid function after three weeks of about 50mg of msm daily and have had to cut right back on the amount of iodine i apply (see the section directly below on msm) or i have difficulty getting to sleep


if you want to take two drops of iodine tincture, they are far better spaced apart, with the last taken about four and a half hours before bed at the latest


there's a lot of finesse with doing this, like selenium  is important


its worth the attention to get right because the medical options are so crucifying and the endpoint for a lengthy period of thyroid problems is thyroid cancer


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if you are supplementing iodine, the houston  no-fenol  is essential to generate more adrenal type compounds as iodine deprecates these  (don't get the chewables!)


no fenol provides tyrosine in a better way than amino acid supplements


the problem with taking amino acid supplements is they feed gut bugs (biofilm!)


no fenol provides more tyrosine by more efficient extraction of tyrosine from fruits and veges and seems to amplify the tyrosine/adrenal pathways in the body and doesn't feed the stomach and intestinal biofilm


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eileen writes:


“For the last 3 weeks while travelling I applied topical iodine tincture in the morning after a shower as usual but splitting oral iodine tincture into 2 lots over the day,


1 drop in a little water around 12 noon, Another drop in water about 4 hrs later,


This seems to really suit spreading an even energy from early morn till mid evening (about 9pm)


This was really beneficial during a quite grueling travelling schedule with hours of driving on some less than ideal outback roads, staying in varied motel conditions and less than optimum food sometimes so it's a pretty good protocol imo, Helped keep me going.”


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andrew asks:


when do you take the drops?



eileen replies:


one at about noon, one around 5 pm, roughly thereabouts. with the topical (1ml), after my shower early in the morn


that's one drop in about 1ml of white vinegar then adding about 3mls of water swirled a lot to mix


it seems to spread the energy in an even way across the day till not long before my bedtime so im happy with that


i think it might even help me be a bit more sleepy at night earlier too which i dont mind as even 11ish is a bit late, i've been going to bed at 10.30 more often and even 10 ish sometimes


getting up closer to 6am but i like that anyway, it seems to be going well for me at the moment ive had so much more energy i'm cleaning up the garden and spring cleaning the house


mind u i think the exercise generates more energy too, when im a sloth it seems to self perpetuate more sloth



andrew replies:


you may have always had a thyroid problem and the new iodine regime is significantly better


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thyroid is required in the diet occasionally (or more frequently if you have an underfunctioning thyroid), iodine supplementation does not get around that need


however the eating of animal thyroids is ambiguous since animal hormones are not bio-identical matches with human


because i hunt i will cut out and eat the occasional thryoid or part thereof, i do find that it is necessary to eat them occasionally, perhaps there are other rare minerals apart from iodine required by the thyroid?


actually i reckon i've removed more thyroids than a surgeon, they do cut away fairly clean but i would assume removing every last cell is not possible


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regular very low dose msm aka the compendium frees up thryoid receptor action and promotes thyroid hormone production very signifcantly improving thyroid function


for msm dosing see my write up msm


warning: msm is a heavy metal mobiliser and needs to be used with caution and not taken if you have mercury amalgam fillings in


also if you have heart or circulation issues, msm can soften the ligaments and connective tissue so that pumping efficiency is reduced which may be a problem


msm, by improving cell permeability may increase the amount of iodine being transported across the skin.


______________________



don't mix vitamin c with iodine as it converts iodine to iodide making the solution clear.


women have a higher average requirement for iodine than men, presumably for the breasts and ovaries and even possibly for the brain which might help explain the higher rates of age related dementia in women


at least one woman has become unintentionally pregnant after no cycles, then taking iodine


if you take iodine the correct way with synergents so you promote the thyroid rather than suppress it, you will necessarily lose weight


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a sign of excess iodine intake in women is sore nipples and breasts and a slight ache in the ovaries, if you reduce the intake, these should stop in about a week.


you can be doing fine in summer but the stress of a damp winter and poor winter food reduces headroom and problems can appear


“well i'd been doing a dropper a day for a very long time yrs even 2 perhaps and it was fine then not long ago i got sore nipples which went on for a week plus some ovary tenderness so i dropped the skin iodine for a week and those problems went, i recommenced skin application of 1/2 a dropper alternate days and it hasn't re-occured - i was also getting tired about an hour earlier each night than usual and i wondered if that was part of it”


“i know the iodine is really helping my menopause transition as i dont get flushes etc which most women do”


_________________



skin applied/topical iodine gives the slow release and continual feed of iodine into the thyroid follicles that seems to best boost the amount of thyroid hormone going into the blood, see figure 2 on this  page


in fact, if you are low iodine, u are best to start with a very small amount of skin applied iodine as this is much gentler on the thyroid than


the skin iodine must feed the thyroid follicles in a way that maximises the conversion of what thyroglobulin is being made into thyroid hormone


the incorporation of iodine into thyroglobulin for the production of thyroid hormone is nonspecific, that is, there is no thyroperoxidase bound intermediate, but iodination occurs via reactive iodine species released from thyroperoxidase  study


topical iodine would be presenting a continual, relatively steady supply of iodide to thyroperoxidase, thus circumventing a rate limiting step, hence promoting the conversion of thyroglobulin to thyroid hormone


every day or second day i spread .5 to 1mm (.6 ml x 44 mg/ml iodine = 26.4 mg iodine placed on the skin, but say only 7% absorbed = 1.85/2 = .92 mg of iodine absorbed on average daily) of the 2.5% gold cross iodine tincture, usually on the buttocks


but i first wipe the area the tincture is to be applied to with a damp paper towel and then let it dry before applying the tincture


the buttock tissue is fatty and gives the slow release of iodine that the thyroid really responds to


i take a rest day every now and then from the .5 to 1 ml topical iodine and may not apply any iodine at all or just put a couple of drops on the my wrist and rub it in with the other wrist


i also rotate the stomach back, upper chest and shoulders sometimes


the longer the bottle has been opened and the lower the level of tincture in the bottle, the more evaporation of iodine has occured, so at the end of the bottle i am using up to 1 ml, while at the beginning of of the bottle i am using say .4 of a ml, its a big help to keep the tincture in the fridge, but be cautious as to the possibility of it being drunk accidently, it is poisonous


keeping the tincture in the freezer is also viable as it doesn't freeze and may give the least amount of iodine loss


cotton buds absorb the iodine so i use an eye dropper


iodine is absorbed best on a clean and scrubbed skin


this amount of iodine needs to balanced up with the compendium mineral co-factors especially selenium, and likewise the compendium selenium needs to be balanced up with iodine


don't spread the tincture over large veins as it is too quickly absorbed through them


i don't know how much iodine this gives as less than 10% is absorbed, also loss of the iodine colour doesn't mean it has all evaporated or been absorbed, rather it is converted to colourless by some reaction in the skin


the slower the release the more iodine is tolerated, the thyroid hates step inputs of iodine, much preferring spaced doses and slow release


you can modulate how fast the iodine is absorbed by placing it in different areas, like on the fatty tissue of the buttocks is very slowly absorbed and might best suit a fragile or underperforming thyroid


.6ml of topical iodine tincture rotating daily between applying to the tummy and thighs, bum and shoulders with a drop on the wrists thrown in is working well, i don't get migriane much and the myeloproliferation is greatly helped


iodine seems to deprecate iron and makes the platelets less sticky/thins the blood signifcantly which is a great help to me with my thick blood !


_____________



there is a bit of narrative following on the inclusion of hydrogen peroxide, unfortunately i have found hp has limited use because of various problems, but there are circumstances that hp can assist with, and in fact would be quite a good diagnostic for heart/brain circulation issues with minor visual disturbances from taking the iodine/hp combo being indicative of heart problems and narrowing of the brain capillaries.


however visual disturbances are on the road to a stroke so i can't recommend it from a safety point of view


a drop of 35% hydrogen peroxide can be added to the mixture create more free iodine, the mixture needs to be swirled back and forth to mix it properly


i do this several times, what really mixes it is the turbulence when the direction of the fluid changes, at a microlevel the forces are huge when you get that turbulence, as powerful as the energy in a star - "cold fusion" in fact


if you swirl it too much, too much iodine will gas off before you drink it


even one drop of hp seems to alter the stomach biofilm to cause the tongue to go white


actually i have found that even one drop of hp is too rough on the stomach so have dropped adding it, but the week or so i did on it, has done some good.


oral hydrogen peroxide causes some degree of blood clotting, even just one drop, so if you have brain blood or other circulation issues or arterial narrowing, never take oral hp, you risk some degree of stroking


see also the  hydrogen peroxide  section


the amount of alcohol (ethanol - grain alcohol) absorbed orally is equivalent to about 10 drops of wine


you would need to be careful that you don't orally ingest a tincture with a toxic alcohol like methyl alcohol, though i don't know of any tinctures sold with this in


__________________



the I2 (pure iodine) in the tincture reacts in the gastrointestinal tract with deiodinated metabolites of thyroid hormone (T3, T2, rT3) to resynthesize the T4 thyroid hormone and elevate its level in blood.


"Single oral doses of I2 to rats produced significant dose-related increases in serum T4 and decreases in T3 concentrations after 2 h." pmid: 1464908


my comment is that this effect with humans doing the compendium is somewhat complexed with good conversion of the T4 to T3 again, but the thyroid hormone promotion is milder than lugols on the skin


__________________



yahoo iodine post, i'm just putting it up, seems significant, haven't worked through it yet


brenda writes:


“I have been on high dose Lugol's iodine (75 mg) for almost a year and a patch test still wouldn't last longer than 6-7 hours. I took all the cofactors. My thyroid levels were good. Despite having really good alternative MDs, something was still wrong. I was still sick with brain fog, weakness, lethargy, severe adrenal fatigue, etc. etc.


I read recently that a few rare folks can't use regular B6 but need P5P form. I'd kissed every other frog so I tried it. 25 mg every evening. Nothing noticable happened so I tried 25 mg morning and night. I began to have dreams (iodine had not caused this for me). Within 1 week of taking it twice a day, I began to have heart palpatations, brain buzzing and thought I'd gone over the edge of insanity. Blood tests were done and my doctor called to tell me to cut back my Armour. I've never been hyper-thyroid before only hypo. who knew. Did an iodine patch test and it lasted more than 24 hours.


All this to say if you can't seem to utilize your iodine, try P5P form of B6. Maybe you are one of those "rare" people like me.


I am off all thyroid supplementation including tyrosine and Armour and have cut my iodine to 25 mg.


My brain fog has cleared, pain levels are down, sleep is great, energy levels are improved and depression is gone. I am calm and hopeful. I would not say I am well but I am on my way.


a reply by marlena


Thanks for sharing. Fascinating. There was some talk here not too long ago, about needing extra B6 when starting Iodine, so I too started to take 50mg of P5P about 10 days ago - also thinking maybe I need the special active kind... I have not had the same response


_____________________________



in australia, new zealand and the uk, the pharmacy sold iodine tincture (also known as weak iodine solution bp or alcoholic iodine tincture) contains 2.5% iodine and 2.5% potassium iodide diluted in 90% ethanol (ethyl alcohol) and the remainder water


'gold cross' is an iodine tincture brand sold in australia, though you may have to ask for it to be ordered in for you at a pharmacy, or a pharmacist can make the tincture up for you (no prescription needed), its normally used as an antiseptic


in the usa, tincture of iodine mild USP, contains 2% iodine and 2.4% sodium iodide diluted in 47% ethanol, with the remainder water and is a standard pharmaceutical item


walmart sell the humco brand and also kroger's sells the tincture, or it can be made up for you by a pharmacist, these recipes go back to the early 1900's and before


humco iodine tincture strong USP (1 or 16 oz bottles) contains iodine 7%, potassium iodide 5%, ethyl alcohol 85% and the remainder purified water - be careful some strong preparations use isopropyl alcohol which is not suitable


lugols (aqueous iodine solution) is 5% iodine and 10% potassium iodide diluted in water only, no alcohol


the advantage of the ethanol tincture over the lugols is the higher percentage of molecular iodine (I2), 57% versus 40%


this higher percentage of molecular iodine in the tincture has almost eliminated my grey hairs, but the lugol's didn't


the tincture does seem better on balance than the aqueous solution as it seems to retain the molecular iodine better and not lose it so drastically to evaporation like the aqueous, and also the tincture is better for skin application since the alcohol takes the iodine into the skin


the solubility of iodine is 1 in 3500 of water, 1 in 8 of alcohol, so iodine is 438 times more soluble in alcohol than water


i use lugols to test or help remove suspect moles, or apply it to the skin as a iodine source for the thyroid


the tincture may benefit from being stored in the fridge to slow evaporation loss, but remember the tincture is a poison and consider who might inadvertently access it in a fridge


even though iodine tincture has a much slower evaporation rate of iodine from the solution than lugols or aqueous iodine, there still comes a time in the life of the bottle that increased amounts of the solution have to be used to compensate for its increased dilution


skin iodine quantities will need to be upped, like i used two droppers full today (2 ml), this was from a half full bottle


'nascent iodine' magnascent? seems to be the same as the pharmacy alcohol tincture diluted by a factor of about five in ethanol, which in fact means too much alcohol is ingested to get amounts of iodine greater than 200mcg


the website for 'detoxified iodine' says it is 1% iodine in 100% ethyl alcohol, wether thats only iodine or a potassium/sodium iodide and iodine mixture is hard to say, if its only iodine in alcohol, the iodine may evaporate too quickly


since the iodine used in 'detoxified iodine' is from seaweed (processed in japan) it may have some bromine in, which may or may not be beneficial


“The one detoxified iodine recommended was from www.iodinesource.com. I ordered 6 bottles. After a few days of 2-6 drops of the detoxified iodine along with the iodoral, I felt better than when I was taking the magnascent iodine (evaporation factor? ed.). I've gave a bottle to my mom and a bottle to my husband and to my girlfriend. My husband noticed an increase in stamina almost right away, like I did. I'm still taking iodoral, because it has a longer half-life, but I take 8 drops of detoxified iodine in water twice a day along with C, co-q10, and isocort. I really like the way the detoxified iodine from iodine source makes me feel. I'm beginning to see a light at the end of the tunnel.” yahoo iodine Message #23925


the detoxified iodine is a bit dilute @ only 200 mcg a drop and expensive


the claimed cayce process of putting the iodine in a magnetic field is meaningless


the I2 iodine is important for forcing receptor refurbishment, just the potassium iodide will ramp thyroid hormones, but you need the other side as well - receptor refurbishment - which takes iodine and not iodide


TSH test levels are only indicative in conjunction with thyroid hormone readings which map a 2d space indicating the level of thryoid hormone resistance, endocrinologists do not seem to understand thyroid hormone resistance/reduced thyroid hormone receptor expression


A 2 dimensional TSH versus T4 graph or chart is in the "Clinical Strategies in the Testing of Thyroid Function " section of this  page,  figure 3 is accessed by "The TSH-free T4 relationship" heading in the left hand frame


TSH receptor antibodies have a complex effect depending on the exact nature of the antibody


a good study showing mechanisms of interference with thyroid receptor function on the nucleus


“Thyroid hormone receptor binding to DNA and T3-dependent transcriptional activation are inhibited by uremic toxins”  here


conceptually thyroid hormone receptors (and there are different types) are extensions of the DNA apparatus in the nucleus rather than a separate receptor on the cell surface


that study says T4 and T3 can be low and tsh normal and the receptor function utterly stymied by uremic toxins which makes nonsense of the conventional endocrinology approach


____________



regarding endocrinologists, just thought i should put in a word of warning in about this particularly money grubbing and incompetent branch of medicine which is still stuck in the dark ages


the thyroid models and measures used do not reflect the latest research ( particularly vitamin D and also gene expression changes) and the whole area is just a disaster



i think it gets all the dumber med students who then have traumatised themselves by the little learning they pick up then just treat the job to milk as much money as they can !


____________________________



a good TSH versus T4 graph is in the "Clinical Strategies in the Testing of Thyroid Function " section of this  page,  figure 3 is accessed by "The TSH-free T4 relationship" heading in the left hand frame


____________



thyroid hormones are only half the equation, every cell has receptors for the hormone and these can get messed or the number reduced


fizzy drinks like mountain dew which have brominated vegetable oil in  (used to hold citrus flavours)  are problematic because of the bromine which messes both the thyroid and the receptors


there's two roads, medicine  OR  supplements and dietary changes aka the compendium™ and BCD™, the second is way more difficult and most people prefer to limp on thyroid meds, but the brain particularly doesn't seem to work well on those


thyroid problems = mental cretinism


only the compendium and BCD will recover damaged brain tissue and delay age related neural decline


recent genetic research is showing a far more convoluted, recursive multi-element thyroid system with a lot of gene expression changes that shows the outdated medical thyroid model to be criminally negligently deficient


basically the thyroid is complexed and recursive and doesn't tease out in the simple segmented way endocrinology claims


___________________



an iodine supplement called 'iodoral' uses a silica carrier to hold the iodine


this silica carrier is quite a large amount and will be giving stomach irritation and absorbing trace minerals into itself, as well as having varying dose amounts as the iodine evaporates from the tablets


i do NOT recommend iodoral, however i can see what abrahams was driving at when he developed it, a step input of too much iodine temporarily graunches the thyroid and thyroid production drops and the silica carrier may give a slower release


a tablet of iodoral is 5 mg of iodine and 7.5 mg of iodide which is too large a dose


b writes:


... warns that iodine over-dose is dangerous, and recommends at most a tenth of that iodoral tablet per day. I use stainless steel kitchen shears to cut/shave off very small amounts not more than about that much for my ASD 6 yr old and double that for myself and have noticed it keeps my dry/cracking/thyroid-related skin problem under control and helps my daughter poop a little.


z. writes:


My oldest daughter started using it, back when she was nine, because she said she has hearing voices, just like now and even though I gave her only half a pill she had a reaction to it.


Her throat started closing up (goitre? ed.).....I hate to think what would have happened if I had given her the whole pill.


c. writes


But what if you have a kid that is already hyper skinny? I mean concentration camp skinny! Is Iodoral good for them also. We tried it once and it sent him nuts for three days!


___________________



the stupid way supplementation is usually done significantly lowers thyroid function, biofilm promotion will be one cause


___________________



iodine binds with tyrosine so you need to be using the "no fenol" enzymes to increase the amount of tyrosine available in compensation for iodine reducing the tyrosine pool


i think the lack of free tyrosine is a major factor limiting the amount of iodine that can be taken, so more 'no fenol' may be necessary


no fenol makes more tyrosine


high iodine doses without supporting 'no fenol' and other compendium co-factors may lead to increased viral susceptibility because of this


Ruth writes: "I'm taking around 100mg of iodine daily. I take both Iodoral and Lugol's 5% drops. I also take vitamin e and c. (I was told by a naturopathic doctor that in order for vitamin c to absorb we need to take an equal amount of vitamin e.) Anyway, even though I am taking iodine, lots of C & E, cod liver oil, B's, pantothenic acid and more, I caught a terrible cold/sorethroat that is flu-like. How can that be? I thought that iodine had strong antibiotic powers?"


___________________



it's actually a strength of the compendium that quite large amounts (1 or 2 mg a day oral and/or skin application) of iodine are needed, since higher amounts of iodine really seem to kick start brain neural growth, but you need the whole compendium supplementation to support it


also biofilm by decreasing cell permeability and general toxicity issues decreases thryoid function


chelation and presumably iv glutathione also is very damaging to the thyroid


thyroid repair is a matter of months to years as genetic damage from hydrogen peroxide has to be unwound


"although the thyroid gland can heal, it is the slowest growing organ in the body. I read (as I recall) that it takes thirty some years for the thyroid to fully regenerate itself. Compare this to liver cells, which I think regenerate every four months. This is why a liver lobe can be transplanted and grow into a fully functioning liver quite quickly."


the thyroid is very demanding in terms of adequate mineral nutrition, especially the "dual seleniums" to reduce hydrogen peroxide damage, and most likely zinc, magensium, lithium and other minerals covered in the compendium


i do not recommend stand-alone iodine supplementation and i take it as a part of the compendium and bcd which deliver the all important cofactors and reduced biofilm toxicity enviroment


if you are very careful with the quantity and spacing, the eating of animal thryoids can be very helpful for thyroid repair


i have eaten game animal thyroids, gently and barely shallow pan fried in fat, which can be very potent with a half life of two, three or four days


mercola says the t3 half life is much shorter than t4, to the extent that dessicated pig thyroid (armour) has to be taken twice a day


amour doesn't contain enough t3 to compensate for impaired t4 to t3 conversion though, so its important to focus on the compendium™ and bcd™ promotion of the deiodinase action in the liver and kidneys converting t4 to t3


"Every tumour of the skin can be completely removed with Iodine Tincture 7%, brushed many times (10-20) per day. When the crust is formed, don’t take it away, but treat the area continuously and wait till it falls without any other intervention except the Iodine tincture. When the crust falls down the third time, the patient is healed.” - Dr. Tullio Simoncini


re the above, i think you are just looking for it to go flat in the case of raised potential melanomas


a patient video testimonial using 7% ? iodine on a melanoma in her ear  alexia


imo melanoma is far better dealt with this way or preferably by freezing as this generates antibodies to kill any stray cancer cells, whereas surgery has the potential to release cancer cells into the blood at the same time as depressing a local immune response


Veronica in oregon writes: "When my son worked on a cattle ranch...the owners would apply iodine to any suspicious spot on the animals ....any growths, cancerous or otherwise and it would dry any and all completely. Many applications cured any lesions."


a selenoenzyme is essential for clearing T3 from the body


so i can see too much selenium, especially methylselenocysteine, reduces T3 too much


on the other hand, not enough selenium will make for hyper from a lack of conversion of T4 to T3 via the de-iodinase selenoenzymes responsible for the conversion


__________________



"A perspective view of sodium iodide symporter research and its clinical implications"  here


look at figure 3A, page 501 [also in my files minerals - iodine - nis]


you can see the immunoactive membrane staining of a so called normal thryoid (bit low on iodine imo, follicle's are too big)


so as part of a normal thyroid you have quite a high level of immunoreactivity


all supplement programs and diets and interventions promote the immunoreactivity except the synergy effect of bcd/compendium and the use of my vitamin d lamp (also high vit d sun booths may be ok - ergoline seems to have put some thought into this)


they can chelate, do iodine, scd, bees candida diet, dan, or do nothing


all lead to death except the compendium/scd


actually people can be such shits about hearing what they don't want to hear i just sit back and watch them rejecting what would help them while following what kills them


__________________



the thyroid can compress the windpipe without any obvious external signs of enlarging


can be nodules or mild goitre


what i love about the thyroid is its very unforgivingness


you can ignore bcd and the compendium and mostly you will get away with it except for the thyroid


and what medicine can do to bring you into a special medical hell once it gets a whiff of thyroid troubles is astounding



-----------------------------




FUKUSHIMA



  I-131  has a half life of 8 days which makes it non-persistent in the food chain and at this point there do not appear to be significant amounts being deposited in the continental usa


the japanese have a  problem,  they are very under-reacting !


habituated by hiroshima and nagasaki ?


good site on what is happening


chris busby


too much iodine especially without the dual  seleniums  creates problems, you are advised to read further on the compendium if you plan to supplement !


caesium - 137 has a half life of 30 years, is well researched and seems a useful benchmark to gauge the amount of fukushima fall out in the usa


"The 30 March press release from the International Atomic Energy Agency (IAEA) reports caesium-137 deposition ranging from 0.02 to 3.7 megabecquerels per square metre (MBq?m–2) at sites 25–58 kilometres from the Fukushima"    article


my note: that's 20,000 becquerels to 3.7 MILLION becquerels


los angeles had a total of an average of about say 4 becquerels from march the 15th to april the 19th which was a peak emssion period from fukushima   map


that will average down as the level of emissions drop


if you want a normative comparison, you have to take the becquerel reading as caesium-137 is not part of the natural background radiative materials


wikipedia claims


"the average human body contains 160 grams of potassium-40 at 31 becquerels / gram gives an average of 4960 becquerels"


another page


"Hence, the potassium-40 content in the body is constant, with an adult male having about 0.1 microcurie or 100,000 pCi. (ed. 3700 becquerels) Each year this isotope delivers doses of about 18 millirem (mrem) to soft tissues of the body and 14 mrem to bone."


 from


banana  radiation dose


this is all pretty rough but the deposition rates are so low in the usa that only I-131 can potentially be an issue because it bioaccumulates within say a one month window, but again apart from some spikes in milk a while back, it does not appear to be an issue from actual milk tests


who has a problem ?


 JAPAN


though the immediate death rate is almost non-existant the long term effects may be as significant as hiroshima and nagasaki !


_________________________



wikipedia again but from quick cross reference check the figures may be accurate, that is the body has about 4000 to 5000 becquerels of the beta emitter potassium-40 !


“ Potassium-40 is the largest source of natural radioactivity in animals and humans. An adult human body contains about 160 grams of potassium, hence about 0.00017 x 160 = 0.0187 grams of 40K; whose decay produces about 5,000 disintegrations per second (becquerels) continuously throughout the life of the body. ”


apart from that one spike of I-133 at one or two stations in usa in april 2011, there is nothing to indicate that any of the fallout is within a bull's roar of this natural scource


_________________________



what chris busby is saying is it is the alpha emitters uranium 238/234 and plutonium that are the problem


alpha particles are 20? times more damaging/genotoxic than beta particles and gamma rays


levels in march 2011 which was a peak emission period are only a bit above background in seattle and california and do not on average represent any increased risk imo


possibly the maritanas and hawaii have had, at peak emission periods, increased risk


by extrapolation, a bit of a holocast has occured in some areas particularly the north of japan, the results of which will no doubt become apparent over the coming years unfortunately !


_________________________



on  uranium  in general, regardless of wether you agree with busby (100x amplification of beta radiation via the photoelectric effect) or the other side (1.3 times?), it is generally agreed that uranium is really quite a bit more toxic than you would expect


so imo the elephant in the room is hair test uranium levels from local sources and failure to turnover through metabolic disorder !


_________________________



japan has much more of a  problem  with fukushima than is coming through the media


fukushima is partially melted down and the total effect is worse than the atomic bombs dropped in WW2 though in a different way !


there's no direct casualties but a lot of genetic damage


the big difference in the assessment of radioactive damage now is not simply the external radiation dose which is how it has always been assessed, but the ingestion of radioactive particles which nuclear power plant meltdowns produce in plenty !


it’s interesting that japan despite all the intelligence of it’s race is so vulnerable to bad decision making at the top which was also it’s problem with making war on the usa in 1941


chris busby is very good and not at all FLAKY


_________________________



busby is actually making some waves in japan, newspapers are using him and he is acting as an expert witness for a town close to fukushima !


he’s saying anywhere within 200km of fukushima is very significantly impacted in terms of health damage


the japanese goverment may be about to find out about an independent judiciary and torts !


imo this new ingested radionuclide model really requires nuclear reactors several generations ahead from where they are now so that any disruption to function shuts down the reactor intrinsically and not just with added mechanisms, so if you defeat the back-up mechanisms the nuclear fuel doesn’t go into meltdown.


this is doubly important so that terrorist or enemy action on the reactor doesn’t turn them in fukushimas or chernobyl


imo the nuclear industry has already been affected and australia is feeling the loss of wealth on it’s sharemarket from this long delay in uranium as a useful electrical power source again ! this is a significant world wide economic burden and more than most things is inducting a period of economic depression and instability


chris busby BBC   interview




when


you


are


right


and


it


is


against


people's


interest


they


only


react


one


way,


they


try


to


eliminate


you!



chris busby is  talking  criminal action against the people making the bad decisions so he could reasonably fear an assassination attempt if he returns there !


a trillion dollars to properly entomb fukushima ?


_________________________



based on  these  figures the increase in radiation exposure by residents in washington state was about .01% in the week following the March 11 earthquake and tsunami in japan !


they give a useful figure for the average radiation dose received !


“ the average person in the U.S. receives about 16.4 microsieverts of radiation dose per day from various sources of naturally occurring radiation, such as radioactive materials in the soil, cosmic radiation from outer space and naturally occurring radioactive materials within the body.”


i know it doesn't account for the "funneling" effect of accumulation in specific organs that busby talks about, but all the same it is a useful comparison


good   video  (very long - 278 meg !)  on contamination and the fallout around fukushima !


the average japanese dose pre-fukishima must have been be quite a bit lower in japan than the usa because in that video (37.07) they say .06 microsieverts per hour which is 1.44 microsieverts per day !


maybe this was/is a factor in their longevity ?



-----------------------------




POINTERS AND USE



iodine deficiency is a crisis in the western world because fluoride, bromides and perchlorates displace it and the diet these days can have a high level of goitrogenic vegetables like cabbage in.


anti-cancer compounds in broccoli and other cruciferous vegetables (isothiocyanates) are goitrogenic and the large amounts eaten today go some way to explaining the suppressed thryoid function that has become the norm today


also in general i think lead is an iodine antagonist


what i am seeing on the autism message boards that half the problem is second generation iodine deficiency, that is, the intelligence of the mothers is noticeably impaired from low iodine/low thyroid in their mothers


low iodine means mitochondrial function is low, and brain blood flow is low and for pregnant women it means unintelligent children


also myelination and neural and other cell differentation and proliferation is low in the brain and nerves


thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein  good pic


myelination is actually delayed in hypothyroid animals and accelerated in hyperthyroid animals


reconditioned thyroid hormone receptors and adequate thyroid hormone make for thicker gastro-intestinal mucosa


T3 and T4 act immeadiately and directly on extra-nuclear cellular components as well as their more well known and slower action on the cell nucleus


T2 has an effect on mitochondria


the thyroid hormones have a governing role on the cell development, proliferation and differentiation process from stem cells to mature functional units


they also drive the development of structural features in the large in the brain during gestation, childhood and presumably still have a structural role in the adult brain


________________________



"It is concluded that iodine deficiency retards both somatic and brain development, the change in the latter case being expressed as a reduction in cell size in the cerebral hemispheres and cerebellum, along with reduced myelination throughout the brain."


"Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat."


for rats: "maturation of oligodendrocytes (defined by process number and length) was enhanced in hyperthyroidism, suggesting a more mature state than in control animals. This difference was even greater when compared with the hypothyroid group, the morphology of which suggested a delay in differentiation. These results indicate that thyroid hormone affects neural stem cell linage and oligodendrocyte precursor cell proliferation and maturation also in adulthood."


_______________________



“Iron deficiency impairs thyroid hormone metabolism because the two first steps in thyroid hormone synthesis are catalyzed by thyroperoxidases, which are iron requiring enzymes. Iron deficiency lowers plasma T3 and T4 concentrations, reduces the rate of conversion of T4 to T3, and increases thyrotropin concentrations. Because of these impairments in iodine metabolism, goitre in anaemic individuals may be less responsive to iodine treatment. At 30 weeks after the administration of oral iodine to children in Côte d'Ivoire, the prevalence of goitre was 64% in anaemic, iron deficient individuals and 12% in those with adequate iron status. The inclusion of an iron supplemented group would have made the conclusions more definite, but these results indicate that combining iodine with iron supplements might reduce goitre more rapidly than iodine alone.”


Dr Flechas: Patient had a development of goiter on high doses of iodine - he looked at iron levels and the ferritin was low. Put on iron and then the goiter went down. Must be a total nutritional program when high doses of iodine are given.


________________________



"Even with a small, 100-amino-acid-long protein, the number of possible three-dimensional structures that the protein might manifest is larger than the number of molecules in the universe."


"A few years ago we showed that on the complicated journey to their final structure, proteins have a large tendency to make mistakes that greatly slow them down," notes Englander. "Proteins need to fold fast because if they spend too much time in one intermediate state, they're vulnerable to aggregation with other proteins in the midst of folding, which can be very destructive to the cell."


http://www.eurekalert.org/pub_releases/1998-10/UoPM-MOPF-011098.php


i think molecules that are like, but not exactly perfect is a big issue especially with heavy metals


all molecules degrade in shape too, which is why getting a good turnover is so important


_________________________



the problem with the thyroid is that its normal operation is highly mutating to thyroid cells, so when you add additional stressors like biofilm toxins and goitrogens like bromine/perchlorate and have low iodine as well


the mutagenicity goes through the roof so you have dysfunction from cells that are genetically out of wack, not to mention precancerous or cancerous


so recovery involves apotheosis (killing) of the genetically awol cells, and that takes quite a while and a very comprehensive broad based approach which medicine does not do


___________________________



iodised salt, while useful, does not provide enough iodine


uniodised salt is not a signficant source of iodine, that includes "sea salt"


there seems to be a belief that armour and synthetic thyroid hormones are a satisfactory substitute for a working thyroid but in my experience nothing beats your own thyroid working properly and the thryoid medications result is below par intelligence


armour provides a bit of t3 but not a lot, its hard to get away from the need to have the bodies t4 to t3 conversion process working properly via the liver, kidney's and selenium based deiodinase enzymes


there is some metabolic mismatch with ingested thryoid hormones, wether its eating an animal thyroid or taking thyroid replacements


iodine is useful for women for reconditioning the ovaries and associated hormones and taken consistently with other synergistic supplements and using my vitamin d lamp can restart periods (3 weeks?)


iodine and selenium are used in ratio, if you supplement iodine in any amount above whats in iodised salt and you are not eating food from selenium replete areas then you will need to supplement selenium as per my dual selenium protocol


selenium passivates the hydrogen peroxide generated in the thryoid to organify the iodide into molecular iodine (on route to incorporation into thyroid hormones), if you increase iodine you need more selenium to provide more passivation and avoid antibody issues, if you increase selenium you need more iodine to compensate for the reduced pool of active hydrogen peroxide


goiter's have an involved mutagenicity from an over-liberal use of hydrogen peroxide to maximise organification efficency


the purpose of oral iodine is to deliver iodine directly to the stomach where it is used, but the amount for oral needs to be balanced, as too much damages the gastric mucosa


there's a need for skin applied iodine to give some sustained release effect as well as taking the oral


colourless iodine solution (ammonium iodide in 90% ethanol) seems to be ok or good for topical use, but the ammonia is a laxative if taken orally


iodine alcohol tincture (antiseptic) also applied this way seems to carry the iodine into the skin better, the downsides are it is more irritating to the skin and alcohol is mutagenic, but for an even sustained release lasting about a day and a half it's tops, this slow release is really what suits the thyroid best.


hopefully the immune stimulating properties of the iodine offset any mutagenicity of the iodine, but iodine appears to be anti-mutagenic if anything


lugols (aqueous) iodine for oral ingestion needs diluting down from 6mg of [iodine + iodide] a drop (125mg/ml) to 1mg a drop (21mg/ml)


there is too much [iodine + iodide] in a drop of neat (undiluted) new lugols to take orally, so that is why you dilute it down.


you need to think in terms of the amount in millgrams/micrograms of [iodine + iodide] you are taking, not dilution ratios per se


the carrier (water for lugols, ethanol for the solution i use) simply carries the [iodine + iodide] and the dilution ratio determines how much [iodine + iodide] is in a drop, but what you are going for is whatever weight of iodine you are targeting


women seem to have trouble with this concept, not discriminating the weight of the iodine wanted from the drop volumes of the carrier


because the iodine evaporates quite readily out of the lugols bottle, you will need to dilute it less as time goes by.


skin applied lugols may or may not need diluting down depending on how evaporated it is


i did try undiluted lugols for 5 days? (12 - 24 mg a day) and think it did some good, but it made me too tired which would be the thyroid getting overloaded with iodine and getting stressed and unable to make enough thyroid hormone


______________________



am experimenting with diluting iodine tincture down for oral


KI = 166 grams per mole, iodine = 126.9 grams per mole, K = 39.1 grams per mole


so KI is 76.4% iodine, so a ml of the gold cross tincture which contains 25 mg of iodine and 25 mg of potassium iodide in fact contains 25mg + (.764 x 25 = 19.1) = 44.1mg total iodine


15 drops per .4 of a ml is 15 x 2.5 = 37.5 drops per ml, which is much more drops per ml than a water based solution becuse of the smaller drops formed with the lower surface tension of an alcohol based solution


44.1mg/ml of iodine for the gold cross tincture = 1.18 mg iodine/iodine per drop


of which iodine is aproximately 57% and iodide is 43%


this is an advantageously higher proportion of iodine compared to lugols which is 40% iodine and 60% iodide


_______________



the discontinued gold cross 'colourless iodine solution' which is 90% ethanol and the rest iodine and ammonia has 28.5mg/ml of iodine = .76mg/drop


this form of iodine, if taken orally, may make for loose stools


ammonia is toxic and irritating to mucous membranes, oral ingestion of this form is not advisable


_________________



for oral iodine:


i put about 2ml of white vinegar in the glass first and a drop or two of the 2.5% v/w I/KI alcohol tincture into that and swirl it around to mix it, then add about 9 or 10 ml of water and swirl again and toss that down the back of the throat


taking this first thing in the morning on an acid stomach may make enough molecular iodine available to regenerate some decayed T4 in the gut lining (nasa study)


"Iodide, in the presence of acid, will form molecular iodine. Molecular iodine will cause of memory affects and background problems due to its adsorption onto glass." the above quote from http://www.wcas.com/tech/iodine.htm there needs to be enough volume of fluid so that the iodine mixture gets to the stomach and is not absorbed in the mouth or throat


the above seems to work well coupled with semi-daily oral vitamin d or vitamin d lamp (my own specially constructed uvb lamp) use, really need that vitamin d to pump the adrenals and pituitary up, changes regulation at the gene level


got my energy back


for supplementing iodine for a family, maybe a drop of undiluted lugols in a jug of a drink, it needn't be hard or much extra work to give, its important to work out the daily amount of intake in milligrams (micrograms?) per person though


i once put a drop of diluted lugols in some water and freshly squeezed lime juice (squeezed on a plastic mold by hand so the drink had plenty of the lime integuement in) and i think the iodine got absorbed by the integument and acted as a very good slow release into the gut as the fiber would not have been digested until well down the intestine


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the thyroid does not like a step input of iodine, taking after meals helps even it out although iodine first thing in the morning on an empty (acid) stomach provides some molecular iodine and seems best


however with the dilute doses of say 2 mg of iodine at a time, the step input issue does not seem to be a problem, so generally i don't take with meals.


the thyroid has a very good ability to regenerate, for up to 30% of radioactive iodine ablated thyroids to recover some function means it definitely regrows, although an exremely slow process (30 years?)


so i think thats part of the very slow improvement you get over a while with taking iodine consistently, the thyroid regrowing


the healthiest thyroid is the lowest volume thyroid (assuming it hasn't been ablated or surgically removed) and its on either side of the windpipe below the adams apple and it should be barely discernable in a mirror, if you swallow, you can see the windpipe moving up and down


"a nodule in the thyroid gland will usually move up and down during swallowing, whereas a nodule that forms in other parts of your neck won't"


you can also pick up cancerous conditions like hot and cold nodules from looking at the thyroid like this in the mirror


goiters may be asymmetric


the amino acid tyrosine does promote thyroid hormone production in conjunction with iodine but seems to feed intestinal yeast giving rise to yeast alcohols.


the houstonni enzyme 'no fenol' used with fruit provides tyrosine in a way that does not seem to feed yeast, unlike tyrosine as an amino acid supplement


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An excerpt from Iodine: The Universal Nutrient by Guy E. Abraham, M.D.


"The bioavailability of a Lugol tablet (Iodoral®) containing 12.5 mg elemental iodine was evaluated by measuring 24 hr urine levels of iodide together with the minerals, trace elements and toxic metals before and after administration of this preparation. The results obtained following iodine supplementation revealed that in some subjects, the urine levels of mercury, lead and cadmium increased by several fold after just one day of supplementation. For aluminum, this increased excretion was not observed usually until after one month or more on the iodine supplementation."


"Iodine solubilizes proteins that otherwise do not dissolve in water. Therefore, it mobilizes the toxic metals together with their protective coating of glycoproteins. This was known 100 years ago."


my comment: iodine encourages a slow turnover of toxic metals


Eileen: ok does that mean it dissolves the protiens that encase the mercury once its entered the body which then enables the mercury to slowly move out


Andrew : it breaks up the molecule basically so it fragments and a certain percentage will be discarded out of the body as waste


its like iodine on the skin, corrodes the molecules in the skin, a slow burning in fact


_______________



iodine actually indirectly chelates in a very slow safe way by cleaving the sulphur-hydroxyl molecules with the heavy metals attached so that the heavy metals still remain passivated by part of the molecule, but are removed by the body


"Iodine inactivates viruses by interfering with the protein coat of the virus by oxidation of sulf-hydroxyl groups."


maybe this is how it increases mercury and heavy metal excretion since they will be bound to sulphur-hydroxyl groups


this maybe is how fish remove heavy metals to some extent


its not a big effect but adds up over time to being very significant


i do notice that iodine dramatically improves the tolerance of organic toxins, likely through a liver-intestine re-circulation circuit of iodine and iodine oxidising or breaking up the toxins in the liver ready for disposal


_______________



iodine is concentrated in two parts of the stomach


the fundus which makes ghrelin, a peptide that displays strong growth hormone releasing activity and also promotes the adrenocorticotropic hormones and has an effect on the immune system


the pyloric which has cells that produce gastrin the stomach acid sensor which have tyrosine in, and iodine binds to tyrosine so it could be forcing reburbishment of the gastrin cells


the oral iodine is to deliver iodine to the stomach, intestine and mucosa, liver-gut circulation and pancreas


"immunostaining of gastric and colonic mucosa showed marked hNIS immunoreactivity confined to chief and parietal cells in gastric mucosa and to epithelial cells lining mucosal crypts in colonic mucosa. In normal human pancreas, hNIS immunoreactivity was located in ductal cells, exocrine parenchymal cells, and Langerhans islet cells"


from "Analysis of Human Sodium Iodide Symporter Immunoreactivity in Human Exocrine Glands" C. Spitzweg et al. 1999


http://jcem.endojournals.org/cgi/content/abstract/84/11/4178?ck=nck


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the rate at which iodine disappears on the skin depends on a lot of factors, one of which is the iodine becoming colourless which can be recoloured with the application of 35% hydrogen peroxide


also the iodine evaporates, so temperature and atmospheric pressure may have a bearing on how much skin iodine is retained


iodide inhibits mRNA and membrane protein expression of the sodium iodide symporter (NIS) genes (pmid: 17726079) and the skin has NIS symporter's so there's a possible theoretical basis for the iodine skin test


however you will need to use 35% food grade hydrogen peroxide on the skin that has had iodine applied to recolour it, as what really happens is the iodine gets reduced to iodide (a white/colourless form) as the I2 binds to the unsaturated fat bonds in the skin


so the speed at which iodine decolours from the skin may somewhat reflect the level of unsaturated fat bonds in the skin or even the amount of natural hydorgen peroxide being made


there is a liver enzyme * stearoyl-CoA desaturase-1*, which helps synthesize unsaturated fatty acids, people who take excessive iodine doses and find that skin applied iodine takes longer than say three or four hours to disappear, may in fact be suffering from iodine induced damage to the liver knocking out this enzyme, hence leading to a lower unsaturated fat content in the skin


people who find the skin iodine takes quite a while to disappear without iodine supplementation will be suffering severe liver dysfunction from biofilm toxins


_______________



the body loading concept and test is misplaced


except for the thyroid, the body sheds most of the iodine pretty quick, maybe a half life of six? hours, and i don't see that is going to significantly relate to any notion of optimality in the different body compartments that use iodine


_______________



its actually difficult to get enough iodine absorbed from skin application, but skin applied gives a very even absorption over time which seems to reduce stress on the thyroid


oral iodine is much more completely absorbed


it pays to increase the no fenol enzymes with higher iodine intake to provide more tyrosine, since iodine cleaves to tyrosine to make the thyroid hormones and also to refurbish the iodated tyrosine in the steroid hormone and insulin receptors


povidine iodine (PI) antiseptic cream, ointment or liquid between the toes can be a way of topping up levels, however since povidine iodine is predominantly molecular iodine (I2), it seems not to iodinate thyroglobulin the same way skin applied lugols does which changes the balance of autoimmune reactivity in the thyroid


this reduction of autoimmune reactivity by betadine/povidine compared to lugols may suit those with thyroid autoimmune issues, however the quantity of iodine absorbed is difficult to control


pain in the thyroid is a worrying symptom of autoimmune issues and may be from the action of the immune system destroying thyroid cells and they take a very very long time to regrow


iodine tincture also seems less inducing of autoimmune reactivity than lugols


largish amounts of oral vitamin d like 1000iu daily can help depress autoimmunity


you can get betadine or hexal povidine iodine from the pharmacy


lugols is basically a KI iodine and povidine iodine is I2 or molecular iodine


they are different in effect, I2 is better for cell turnover and detox but its more depressing


PI is a useful antifungal agent against yeast or tinea on the skin, though continued use can feed rather than destroy the fungus


it may be that the rest of the body (see quote below) can use iodine at higher levels than the thyroid can tolerate


"our detection of significant quantities of hNIS gene expression in thyroid gland, salivary glands, thymus, pituitary gland, pancreas, testis, mammary gland, and gastric mucosa, and of lower degrees of NIS gene expression in prostate, ovary, adrenal gland, lung, heart, and nasopharyngeal mucosa suggests that iodide transport in some of these tissues may be a specific property conferred by the expression of NIS."


the above from "Analysis of Human Sodium Iodide Symporter (hNIS) Gene Expression in Extrathyroidal Tissues and Cloning of Its Complementary Deoxyribonucleic Acids from Salivary Gland, Mammary Gland, and Gastric Mucosa" by spitzweg et al


interestingly the salivary glands, gut mucosa, choriod plexus and breasts have a need for iodine and have the transporters (hNIS) to take it in


the body will load gastric mucosa with iodine if it can


"In vivo studies on rats have demonstrated that considerable amounts of iodide are transported from the bloodstream into the gastric lumen"


[Sodium-iodide symporter mediates iodide secretion in rat gastric mucosa in vitro. Josefsson M.]


also its becoming apparent there is a spectrum of intake with lugols and having just worked out how much i have been taking the last week @ 6mg iodine a drop of undiluted lugols and between two and four drops a day which is 12 to 24 mg a day (i didn't realise i was taking so much)


that was a 'chemo' dose and has some benefit that is hard to describe, but 'clearer' might be one way


but its high enough to stress the thyroid and the thyroid drops back thyroid hormone production so it was making me sleepy


another factor in the sleepiness is high dose iodine seems to load or affect the brain directly in some way


today i just did one and 1/2 drops, 9mg and i feel much more energetic


i my feeling is 3 or 4 mg of iodine daily from all sources is an upper limit unless you have metastasized thyroid cancer and thats actually too far into thyroid depression for me who has about 2mg a day


woman  i know of on the net takes 125mg of iodine a day for metastasized thyroid cancer - impressive!


actually i see she has gone back down to 100mg, so it sounds like 100mg is an upper limit


after a while of supplementing iodine, coupled with my vitamin d lamp use, any lymph nodes seem to have shrunk and this has happened for another person using my protocol


iodine may increase the need for manganese and chromium, the thyroid seems to demand an amazing spectrum of minerals to function properly or in an enhanced fashion, basically all the minerals in the compendium


manganese seems to be utilised in ratio to iodine, more iodine needs more manganese


magensium and zinc are also important to thyroid function


methylselenocysteine (a form of selenium) is used to make the proteins that deiodinate T4 to T3, in other words the deiodination enzymes are selenoproteins


selenium also potentiates the conversion of T4 to RT3 so you need to be careful with amounts


more RT3 is made as a way of slowing down the metabolism when the body is stressed


“You must store iodine in an air tight bottle, but not necessarily dark (to keep out light). The vapor pressure of iodine gas will take care of losing too much since at any particular temperature, the amount of iodine that can evaporate/sublime is limited by its vapor pressure, once the air has been "saturated" with iodine, you wont lose any more. That is why it is better to keep the bottle as full as possible, so there will be as little air in the bottle for the iodine to sublime into.”



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IODINE AND SKIN RASHES, UPPER LIMITS TO ORAL USE



one of the limits of how much iodine you can take is that after taking it for a while, either the skin loads with it or the skin bugs mutate to take advantage of the extra iodine or both


so you get skin rashes or promoted skin fungal condititons


one thing that helps with this is to use 'canesten' which is sold as a washing machine antiseptic just for this purpose, i mix it in with the final rinse water and then let it agitate a bit then leave it for a little while to let the clothes soak for a short while in the canesten/rinse water mixture


not being a fan of homeopathy, i do the opposite and put three times the amount of canesten they recommend



L. writes of taking too much iodine:


I tried Iodoral for 10 days. I began with the full 50 mg and did this for five days. I felt very bad the whole time, had skin eruptions and a light reddish rash on my face, depressed, considerable sneezing and finally ended up with a sinus headache that was close to a migraine. And this was after cutting back to 25 mg/day. When I stopped, I immediately felt better.



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THE DANGERS OF TOO LITTLE OR TOO MUCH IODINE



the thyroid, when it makes thyroid hormones, 'roasts' the iodine chemically to a form suitable for incorporation into thyroid hormones


this process is intrinsically mutagenic since it involves hydrogen peroxide


if you increase iodine without a sufficient background of the compendium™  supplements (especially selenium) and you have high biofilm toxins, then you can severely increase the mutagenicity that the thyroid generates as part of its thyroid hormone making operation


on the other hand, if you don't have sufficient iodine then the thyroid increases the use of hydrogen peroxide to absolutely maximise iodine 'roasting ' (organification) for greatest conversion of what little iodine there is


hence more more mutagenic pressure from the extra hydrogen peroxide use


thyroid nodules are the first step to thyroid cancer


i can't make sense out of the high dose iodine protocols (10mg - 100mg a day) and the owner of the yahoo iodine message  board  which promotes this protocol also promotes chelation and has banned me for putting the other side of the story


this owner recommends 12.5mg for pregnant women, with its concomitant potential for kidney and liver damage, she's a total fruit loop


actually she is not well at all, so allowances have to be made, but i have noticed how overconfident these not-well people on the message boards are, like if they have got it so right, why do they have so many problems?


this question is not asked and they prosletize their stupid incompetent ways to all willing to listen and there seem to be a fair few of those


one unpleasant side effect of the high dose protocols is the suppression of thyroid function and the necessity of a thyroid hormone replacement (armour?), also oral thyroid hormone may be necessary to reduce thyroid mutagenicity if the thyroid is intact and producing thyroid hormone


too much iodine destroys proteins in the thyroid


another unpleasant side effect is liver (and kidney) damage as evidenced by liver enzymes getting into the blood from injured liver tissue, the liver damage also deprecates deiodination of T4 so TSH rises (TSH is governed by both T4 and T3 levels)


"most of the T3 produced each day is formed by the extrathyroidal 5'-deiodination (outer ring deiodination) of T4 . this reaction is catalysed by T4-deiodinase. the liver and kidney have the highest T4-deiodinating activity per unit tissue, and probably the source of much of the T3 in serum. however deiodinating activity is widely distributed, and it is likely multiple tissues contribute to overall extrathyroidal t3 production."


the above paragraph p265 from 'endocrinology and metabolism' by frelig and frohman, google books


daily very high dose iodine (25 - 125 mg) supresses metastasized thyroid cancer, even with high  thyroglobulin  levels - i know of a situation where a woman is still surviving with a Tg of 12 on high dose iodine (came down from 24 to 12 when she went to the high dose - 50mg)


I2 is important for chemotherapeutic effects for breast cancer


i suspect that some mutations of breast cancer may be much more susceptible to high dose iodine than others


since the breast uptakes iodine, then some cancers are likely to uptake considerably more iodine than others


more and more i am understanding the role of biofilm toxins in causing thyroid and breast cancer


______________



potassium bromate (KBrO3) is an oxidizing agent used in breadmaking and is toxic to the kidneys


inferring from this potassium iodide (KI) as being similarly toxic though its not as clear cut as potassium bromate


you can see there are problems with high dose iodine protocols


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a mother on the yahoo iodine board had an 11 year old girl with goitre and the photos she had put up showed a dramatic disappearance of the goitre over a month (november to december 2007)


its one of the very few black and white things i have seen on the web though there are still signs of a mild swelling in the last pic


she was hypothyroidal and her doctor said that she had white blood cells in her thyroid and probably had graves disease


but the very interesting thing is it was 37.5 mcg of levoxyl plus a 12.5mg (iodine/potassium iodide) iodoral tablet daily that her mother was giving her


the levoxyl/t4 may well have been instrumental in keeping the down the need for the thyroid to make hormone and the iodine somehow reduced the autoimmune attack on the thyroid


when the mother discontinued the iodine on the endo's instructions, after 2˝ days the girl developed a sore throat in the goitre area, so the mother recontinued the iodoral


its interesting that the levoxyl (T4) did nothing to stop the autoimmune attack


also the childs TSH rose up to 50 on the iodine which is an interesting indication of the iodine interfering with the production of thyroid hormone via liver and kidney damage causing impaired deiodination of T4 and/or interfering with the thyroid hormone receptors (iodine added after the 8th of october)


biofilm toxins are also a cause of liver damage


10/08/07 TSH 0.040 Free T4 1.03 (0.50-1.60)

12/18/07 TSH 6.260 FT4 0.67 (0.50-1.60)

1/8/08 TSH was 50! FT4 was .55 (0.50-1.60)


_________________



"Organification = covalently bound or attached to an organic molecule. Iodine must bind to lipids and proteins. Part of this binding is to thyroglobulin (protein) to create thyroid hormones (T1,T2,T3 &T4) It also binds to lipids creating iodolactones. These are used as control mechanisms. For instance in hashimotos the issue is with an over production of hydrogen peroxide. This is inside the cells and burns and burns the cell until it destroys it. The Iodolactone act as a "brake" on the oxidation process making it normalize and not run out of control prior to mutating the cells which would cause the increase in antibody attack. This only occurs when there is enough iodine being supplied to create these newly organified iodolipids. That is why sometimes there are issues with lower doses of iodine. You supply enough to make thyroid hormones but not enough to organify the lipids."


you can have enough iodine for thryoid hormones, but not enough to organify fats and that is necessary to keep thyroid and other cancers like breast cancer away


oral thyroid hormones can give some relief from poor thyroid function but avoiding cancer is a more difficult question and the doctors won't help there


a high fat diet like i eat and is really part of BCD, needs heaps of iodine


i really notice that by the time my iodine tincture bottle is half empty, it has lost enough iodine through evaporation that i have to double up the tincture doses


iodine tincture antiseptics used to be used a lot, but hardly now at all, so thats why everyone is so low iodine now and people eat a lot of polyunsaturated fats which are still fats


" A new approach was stimulated by the finding that thyroid cells were able to iodinate polyunsaturated fatty acids to form iodolactones and by the identification of alpha-iodohexadecanal (alpha-IHDA) as the major compound of an iodolipid fraction. alpha-IHDA exerts multiple inhibitory effects on adenylate cyclase, NADPH-oxidase and thyroid peroxidase.


Therefore, it is speculated as a mediator of the Wolff-Chaikoff-effect and to be involved in the autoregulation of specific thyroid functions mediated by the cyclic adenosine-3',5'-monophosphate (cAMP)-pathway. Meanwhile 6-iodo-5-hydroxy-8,11,14-eicosatrienoic acid delta-lactone (delta-iodolactone) has been identified in human thyroid tissue and it could be demonstrated that this iodoeicosanoid specifically inhibits signal transduction pathways induced by local growth factors such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF). Therefore, delta-iodol-actones seem to act as mediators of iodine, especially in the autoregulation of cAMP-independent thyroid cell proliferation."


the immediate above two paragraphs from "Iodolactones and iodoaldehydes--mediators of iodine in thyroid autoregulation" 1996 pmid: 8981000




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IODINE AND SKIN D/VITAMIN D DEFINE A DIFFERENT SPACE



uvb skin d/vitamin d change gene expression in the pituitary most likely having a complex of effects but tsh increases amongst them


anyway i have gone back to daily vitamin d lamp use and the iodine seems to make the viral immunity more robust despite the immune depression from the lamp use


iodine enables higher levels of vitamin d without so much anti-viral immune sytem depression


this 'enabling' may come from more thyroid hormone being produced by the action of vitamin d on the pituitary and possibly more thyroid hormone promoting the conversion of more vitamin d to its active 1,25 form


skin vitamin d and iodine/thryoid promotion is a potent improver of heart function and the cardiovascular system and the converse also holds


the thyroid strongly regulates heat  dispersion  of the body through vascular expansion and contraction !


low thyroid/iodine/skin d leads to less efficient contraction (the pressure phase) of the heart among other things (fluid retention?)


---------


iodine definitely has a synergy with skin d so one factor might be that uv on the skin makes conjugated linoleic acid (CLA) since iodine concentrates in the skin


"Typically, trans fatty acids are bad for health, but scientists at the University of Arkansas Division of Agriculture have coaxed out significant health benefits by juggling the molecular structure of soy oil.


Andrew Proctor, professor of food science, and graduate student Vishal Jain produced soy oil rich in conjugated linoleic acid. Also known as CLA, studies show it gives the immune system a boost and helps reduce the risks of cancer and diabetes.


Studies have also shown that humans eating diets rich in CLA reduced body fat and waist size, Proctor said.


Proctor and Jain have used the converted oil to produce potato chips that contain high concentrations of CLA. Proctor calls them "healthier potato chips."


"It is still important to have a low fat diet and we do not propose increasing the fat intake, but a few chips will provide needed CLA," Proctor said.


"Our goal is to develop a popular food item that offers high concentrations of CLA without increasing saturated fat intake," Proctor said. "Potato chips suit this purpose well. Subsequent studies may include development of high-CLA salad oils and dressings."


Marjorie Fitch-Hilgenberg, associate professor of human environmental sciences and director of the dietetics program in Dale Bumpers College of Agricultural, Food and Life Sciences at the U of A, said trans fatty acids occur naturally in meat and dairy products, but in small amounts. Of greater health concern, she said, are the higher concentrations of trans fats artificially produced when hydrogen is added to vegetable oils -- producing hydrogenated oils -- to extend shelf life and make solid shortenings.


Such trans fats increase levels of low-density lipoproteins, or LDL cholesterol, Fitch-Hilgenberg said, and reduce high-density lipoproteins, or HDL, which counteract the artery-clogging effects of LDL.


Proctor said their process uses only refined soy oil, which does not introduce the health risks associated with hydrogenated oils. When CLA is synthesized, the result is a trans fat oil with health benefits.


CLA occurs naturally in beef and dairy products, but at such low levels that no benefit is obtained in a normal, healthy diet, Proctor said. In an earlier experiment, Proctor found that CLA could be synthesized in soy oil by irradiating it with ultraviolet and visible light, although that first process still produced only low amounts, similar to that present in beef and dairy.


Proctor and Jain experimented with an instrument that exposes oil to UV light more evenly and produces significantly higher CLA content of soybean oil. The photo-irradiated oil contains 25 percent CLA, Proctor said. Beef and dairy products contain less than 1 percent.


the term "trans fatty acids" refers to the manner in which carbon atoms are bound together in the oil molecules. jain adds iodine as a catalyst to destabilize double bonds that connect the carbon atoms. proctor said energy from the photo irradiation causes those double bonds to shift position, a chemical change that results in the formation of cla. later, the iodine is filtered out of the product.


"Changing the position of the double bonds makes all the difference in the world," Proctor said.




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IODINE AND TEETH



from the yahoo iodine board (june 2007):


A while back someone posted that their teeth hurt while taking iodine and I was wondering if anyone solved the problem. I had terrible pain in one tooth (a tooth that is crowned) while taking iodine. I had 2 dentist check it out and they said nothing was appearently wrong with the tooth/crown. I stopped taking the iodine and within about two weeks the tooth stopped hurting. Does anyone have any answers...? by S. (female)


no I don't have answers, except that my teeth became visibly thicker and bigger on enough Armour (calcitonen?) B4 Armour I had baby teeth. How much Iodoral were you taking? and how much magnesium? by G. (female)



my comment:


since iodine seems to make some body fluids thinner and flow better, a possibility is that the fluid in the dentin tubules flows more easily and the extra movement from this makes for tooth sensitivity to hot and cold as the tooth pulp responds in this way to the increased fluid movement




----------------------------




I DON'T THINK THE THYROID EVER REALLY RECOVERS ONCE KNACKERED



i don't think iodine by itself is adequate if the thyroid is damaged beyond a certain point, thyroid cells can take thirty years to regrow


i think today's diet  is so goitrogenic too  !


“ But one type of hair loss is considered unique to hypothyroidism. It is the loss of the hair in the outer edge of the eyebrows. This is a characteristic sign of hypothyroidism, and is not linked to other diseases, and so many physicians consider it a very important clinical sign ”


“ One further test your doc can do is an ultrasound on your thyroid. I had all the classic symptoms of pretty severe hypothyroid, but went undiagnosed for years b/c my TSH levels were only borderline hypo. I went to an integrative doctor last year, he did an ultrasound, and it showed that my thyroid was covered with cysts, and hadn't been working efficiently in years.

Even though my numbers were "normal", the hormones weren't being processed properly by my body. He also looked at my eyebrows, puffiness under my eyes, and tested my achilles reflex  (I didn't even know I had one) ,  which was slow, and a few other tests that I'm sorry but I can't recall at the moment. There is much more to it than just what the numbers say ”


the above quote from the  livejournal thyroid diseases  messageboard


she also said that one of the lobes was slightly enlarged and while she couldn't see any raisedness the doctor was able to feel that the thyroid was abnormal


a spar or hot bath is a  remedy  for low thyroid function ?




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THE PROBLEMS WITH MEDICAL THYROID HORMONES AND BIOPSIES



thyroid hormones are the volume control switch for the metabolic rate and lock directly into the cell nucleus to turn the rate up


the thyroid hormones control the rate at which the body burns energy, it's that simple


_____________



if you are metabolically toxic the body deliberately makes you hypo by raising rT3 or the rT3/T3 ratio as a defense mechanism, like driving a car slow that has engine trouble


so if the body has downregulated its response to thyroid hormones by upping reverse T3 or the rT3/T3 ratio and you artificially pump up t3 with an oral hormone supplement and increase the metabolic rate, then you are running into the various metabolic toxicity issues that the body has been avoiding with increased rT3


_____________



thyroid hormones are made of the amino acid tyrosine and iodine


the houstonni enzyme "no fenol" provides tyrosine


thyroid medications do not address the dynamic "on demand" nature of the way the body needs t3 in its various compartments like the brain or placenta


in addition you never get adequate blood flow to brain with anything except with an adequate level of the bodies natural deiodinases providing t3 from t4


vitamin d is also important for brain blood flow


fainting can be a low thyroid/vitamin d symptom


levoxythyroxine does not necessarily shrink thyroids because it only addresses one of several pathways to goiter


when the thyroid follicles get starved of iodine they start to expand to gather every last ounce of iodine from the blood


thats basically why the thyroid enlarges


unfortunately the goiterous or iodine deficient state is highly mutagenic so there's always the possibility of cancer


however thyroid cancer is avoidable through the compendium™ and BCD™


____________



a message to americans:


i am from new zealand which is iodine deficient and we are brought up on the importance of iodine unlike the usa where it seems to come as a surprise that goiter and thyroid cancers are iodine deficiency problems


plus you eat so badly and the dietetic advice is so 1960's and get biofilm (candida) toxin problems that impair iodine uptake into the thyroid and interfere with thyroid hormone manufacture and create autoimmunity problems


and then take no personal responsibility for health problems and toss it all over to the doctor and when that blows up in your faces you don't want it pointed out


you have all the most advanced equipment but theres no brains either side of the doctors desk


theres something disgusting about subordinating oneself to the ongoing fee needs of the medical system and personnel and being rendered road kill because of it, but it does seem to be the general american attitude that this is the wanted thing to do


no spirit of rebellion


___________



the problem you americans have is you only value money, so volunteer work you rubbish and anything that costs you praise to the sky's, the more it kills you the better, and the more praise you screetch


___________



the research below from "Neuronal correlates of overt hypothyroidism measured by FDG PET", Waltraud Eichhorn et al (2007)


Compared to the normal controls, the hypothyroid patients showed a significantly decreased metabolism in large parts of the bilateral thalamus and in the bilateral posterior insula (p<0.001). Under euthyroidism, (when thyroid meds have been added, possibly just t4 ed.) we still found deactivation of thalamic areas (p<0.001), however, in the posterior insula no significant clusters were detectable. In the paired t-test for the longitudinal study (n=7), the patients showed after remission to euthyroidism compared to their hypothyroid state an activation in the primary visual cortex bilaterally and in parts of the sensory association cortex (p<0.005) whereas no significant deactivations were found


Conclusions:


Hypothyroidism-associated psychopathological symptoms are correlated to regional metabolic changes in main structures of the thalamus and in the functionally connected insular cortex. Compared to controls, the deactivation in thalamic areas still remains detectable under euthyroid conditions. The activation of visual and secondary sensory cortex in the patients' course is surprising and might be the correlate of compensatory neuronal processes after metabolic remission.


my comments:


there's obviously a continuum of thyroid elicited brain function, what passes for 'normal' these days is well below par


people on thyroid meds still seem to fall a long way short on brain function, just don't seem to be able to pick up new points of view, this deactivated thalamus is hurting them


the thalamus acts as a controller and director of sensory input - instead of vision being a process going straight from eye to cortex, it's more of a loop through the thalamus


_____________


all the medical theory on the thyroid is misguided because they don't allow for selenium governing so much of the thyroid hormone pathways, especially methylselenocysteine


the thyroid is an energy regulator and there is an intrinsic complex physics associated with the feedback loops and recursion necessary, quantum, and not readily definable


  study


if you have the selenium right then a little bit of extra iodine will make you more active and sleeping shorter and a lot more will make you sleepy


and not enough you will be tired and lacking energy as you need the selenocysteine (from the vrp methylselenocysteine supplement) proteins to build the enzymes converting T4 to T3


a build up of T4 and not enough T3 is symptomatic of a selenium shortfall with respect to iodine


functioning kidneys are very important for filtering out degraded and malformed thyroid hormones, which is why thyroid function is an early casualty of chelation with the mercury mobilisation of chelation permanently damaging the kidney tubules


_____________



the whole problem with the thryoid is the huge number of interrelated feedback links (including immune system response) and the wide spectrum of important minerals


more selenium can downregulate thyroid hormone production, but the compendium as a whole upregulates thyroid hormones somewhat, though supplemental thyroid hormone in the form of eating thyroids (feral !) may be necessary


an interesting  study   on the  vicious circle  of decreasing thryoid hormone reception and decreasing serum selenoprotein levels and the converse of increasing thyroid hormones and increasing selenoprotein levels !


_____________



FNA's can draw cancerous cells back along the needle path or permit carcinomas to spill from pierced membranes


the thick needles were so bad for this they went to fine needle aspiration


scapel excision is safer than needles


what the practical probability of FNA's causing metastasis is i don't know, but its a real concern


yahoo iodine post:


"Also, you may reconsider a needle biopsy in favor of an excisional one. Needle biopsies have a 50% higher chance of spreading any cancer to the lymph nodes than an excisional biopsy where they carefully remove the entire lump."


"Yes! This is very true! The surgeon who removed a lump for me told me the same."




---------------------------




ULTRASOUND REVEALING ROUGH TEXTURE ON THE THYROID



question (questioner has fibromyalgia - 02/2008):


First blood test showed normal Thyroid. Ultrasound showed a node on left side with the thyroid having a rough texture. Has anyone heard of this?


1st answerer:


My ultrasound showed a rough texture as well as an enlarged thyroid with nodules. My Doctor explained the rough texture was the result of my body thinking my thyroid was the enemy and trying to destroy it. The pitting and scaring were from the fight of the immune system vs the thyroid.


2nd answerer:


My doctor also said the rough uneven texture of the thyroid shown on the ultrasound was consistent with Hashi's - the antibodies attacking the thyroid. Sounds awful but that is how it is .



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IODINE CURES OVARIAN CYSTS, LACK OF IODINE CAN CAUSE THEM



S. writes on the yahoo iodine board (november 6th 06)


I started Iodoral 3 months ago. In the last 5 years, my ovaries have been closely followed by ultrasound since my mother died from ovarian cancer at age 62. She was diagnosed at 55. I am 47. All of my ultrasounds in the last 5 years showed mutiple ovarian cysts. Last week I had another ultrasound (the first since starting Iodoral) The ovarian cysts are insignificant enough that the radiologist didn't even mention them in the "impression". I checked with the doctor to be sure. She said it's as if you have no cysts on your ovaries now. I find this quite interesting because in 2002, I was put on Lithium which I now understand "strips" the body's iodine and I was on it for 4 years. I didn't do a loading test prior to starting Iodoral, but my patch/skin test was gone in 3 hours. I just thought you folks might like to know about this finding.


again on december 12th 06


I received a call from my "holistic" gynecologist a few minutes ago. I couldn't wait to share. A few weeks ago, I reported to you all that my multiple ovarian cysts (as per 6 years of ultrasounds) are gone since using Iodoral, and now today, the doc called to tell me that my biggest fibroid is gone as well. I had 3 fibroids, 2 small and 1 large and the large one is GONE!! I am so psyched!!



my comment:


iodine appears to be important where you have the body making fluids like the choroid plexus (makes fluid in the brain that is responsible for zapping beta amyloids (alzheimers plaques) and the ciliary body which makes the aqueous humor in the eye


and i guess the follicular cysts and luteal cysts in the ovaries as well


---------


"Ovarian cysts develop as a normal part of a healthy menstrual cycle; mature ovaries very often have cysts in them. The cysts that appear during the regular activity of the ovaries are called functional cysts. There are two types of functional cysts, known as follicular cysts and luteal cysts respectively.


In the ovaries, immature eggs are stored in the follicles, which are tiny tube-like membranes. When menstruation begins in the early teens, women have nearly 400,000 follicles that store and produce eggs in the ovaries. During each menstrual cycle, an egg matures inside one of the follicles, and the follicle sac fills up with a liquid (liquor folliculi) that nourishes the growing egg. This swollen follicle is a follicular cyst. When the egg is released into the fallopian tube during ovulation, the follicle opens or ruptures and the fluid drains away."



----------------------------




HIGHER SATURATED FAT IN THE DIET NEEDS MORE IODINE



L. writes:


“Dr. Flechas told me the higher saturated fats in the diet, the more iodine is needed.”


A. replies:


“This is really interesting, and actually would not surprise me. There is definitely a correlation between high sat fat intake and breast lumpiness and tenderness. In fact, just the other day, a woman came to me saying that just from adding natural whole milk to her diet after many years, her breasts started to ache – and it had been years since having any problems like that. I know it is true for me that the inclusion of red meat, cream, bacon, etc causes breast tenderness. I only eat the naturally raised stuff, too…right off the farm, but it does not seem to matter. I wish I knew what the correlation was.”


my comment:


unsaturated fats are probably an issue too, basically fat acts as an iodine sink, hence a high fat intake with no increase in iodine intake will leave the ovaries and breasts starved of iodine, and breast and ovarian cancer and cysts are iodine deficiency diseases


"Researchers found that after four years, women who decreased the amount of dietary fat they consumed were 40 percent less likely to develop ovarian cancer than women who followed normal dietary patterns. As expected, no effect was found during the first four years because preventive benefits on cancer often take many years to develop. Ovarian cancer affects about 1 in 60 U.S. women in their lifetimes and has the highest mortality of all cancers of the female reproductive system."


women’s health initiative dietary modification  trial


see also the write up on iodolactones in the "the dangers of too little or too much iodine" section




----------------------




GENERAL DISCUSSION AND SKIN APPLICATION



fluoride and chlorine/chloride (salt) displace iodine in an order of halogenic precedence.


iodine may be needed several times a day since the thyroid can be too grabby and take the iodine out of circulation and leave the - immune system, intestinal mucosa, pancreas, brain fluid making organ and vitreous humour making organ - starved of iodine.


interestingly the choroid or brain fluid making organ is able to break down the beta amyloid protiens that build up in alzheimers - see write up at the bottom of this page.


microdose lithium can be used to spread iodine more evenly in the body and bring down iodine levels if need be (see index for lithium). iodine and lithium aspartate as used in these pages with the two or three times daily dose is is very mood stabilising.


in new zealand and australia the free flow agent in salt, 'aluminium sodium silicate' - E554 - is a stomach irritant/ulcerative colitus promoter and also seems to absorb needed trace minerals. see my web page on 'salt' in the compendium index. all the 'driers' in free flow salt have issues imo (in my opinion).


-----------


i am not keen on kelp as a source of iodine as kelp has high levels of aluminium and arsenic and indigestible complex polysaccarides. to restate, kelp is unacceptable.


j_n_t writes:


I still had thyroid antibodies after taking the kelp for a year.. probably increased, but a different test by a different lab ..so can't really say.


Microsomal were 1/25600 (normal <1/100), also TG antibodies in hundreds as usual.


my comment:


the gums and polysaccarides in kelp must be promoting biofilm and leaky cell walls including the thyroid follicle walls as the body produces microsomal antibodies in response to microsomes escaping from damaged thyroid cells


-------------------


breast development in males can be caused by low iodine and thyroid minerals (seleniums, zinc, magnesium, manganese), particularly low iodine as iodine breaks down the fiber forming in the breasts. low iodine can also mean the fluoride intake is too high as fluoride displaces iodine. low iodine and thyroid minerals are a big factor in breast cancer in women and the lower intelligence of children and adults these days.


as far as i can see the breast takes huge amounts of iodine for milk and the feeding baby


women have a much higher requirement for iodine and probably selenium than men i think


humans are an offal eating animal and used to eat the thyroid's and pancreas's in the animals they hunted or scavanged.


the evidence seems to be that humans were responsible for the extinction of megafauna so our nutritional biochemistry evolved around the plentiful supply of nutrients available in megafauna offal   study


that is, quite high iodine sources were available so humans have a frequent and high requirement for iodine and are not very efficient at retaining it, unlike marsupials which recycle it very efficiently


the compendium supplementation and BCD which are quite carnivore oriented may also also hit a nutrient space that has a high iodine requirement which would have been met from the thyroids of the whole eaten carcass


if you do things for the thyroid that fixes a lot of other things because the blood is filtered through thyroid and zapped by the iodine there as a natural antifungal/antibacterial/anti-viral


i can't cope with the mercury, arsenic and pcbs in seafood so have dropped eating seafood and am doing much better without, and this seems to have greatly freed T4 to T3 conversion after about five months of stopping .


as a consequence of this i can use much larger amounts of iodine twice a day and the difference is amazing, consistent energy and much better mood


so much so that i think being able to utilize more iodine in a way that gives a strong balanced energy and doesn't affect sleep too much is a strong indicator of substantially reduced heavy metals toxicity


T4 is two tyrosine amino acids bound together with four atoms of iodine and T3 is just one iodine atom lopped off the T4, so the T3 hormone now fits into the lock in cells for it, and can activate them.


the houstonni enzyme 'no fenol' will help with tyrosine avaliability


poor T4 to T3 conversion is a central issue and is easily interfered with by heavy metals and selenium is essential


also alcohol based iodine antiseptic solutions - "iodine tincture" made by gold cross here in australia - 2.5% v/w iodine and 2.5% v/w pottasium iodide which aproximates to say 43 mg/ml of iodine - are good for slow release iodine but may rise to a rash with consistent use in the same skin area. on the bottom might be a good place to apply it.


when travelling i will just take the iodine tincture and use topically and also one drop orally which is about 2.4mg of iodine


as far as i can see iodine may be applied just about anywhere on the body, the main limitation is you may have to vary areas of application with intense solutions, because they can be irritating if applied in the same spot too frequently


some women have applied it to the breasts to help with fibroids


i would keep it away from around the eyes



"The influence of ambient temperature on the evaporation of iodine from skin is significant: within the first minute (ed. after application), the losses of iodine by evaporation are: 10-15% at 9° c; 18-25% at 24° c; and 35% at 37° c. "   abraham


only a brown glass bottle should be use for storage as iodine reacts to light and ingresses into plastics.


the iodine in my diluted iodine bottle was getting progressively weaker because it had a dropper type cap and the rubber in the dropper was absorbing all the iodine from the vapour in the bottle.


i have now put it in a bottle with a hard plastic cap like i used to, and have the dropper separate, but even so the iodine slowly evaporates out into the airspace above the diluted water solution, the larger the air space in relation to the volumes of diluted solution, the worse the problem so i usually replace the solution before the end of the bottle or increase the number of drops i use.


iodine is surprisingly volatile and also slowly evaporates from salt i think. i have to top up the diluted iodine solution quite often with a drop of neat lugols.


you can tell wether the diluted solution is too strong or weak by wether you get energised enough or over-energised and start sleeping too short.


i keep both (neat and diluted) bottles of lugols iodine in the fridge now to slow evaporation, and this works really well, but be careful of anyone inadvertently drinking it, assuming its a drinkable fluid being in the fridge.


if toddlers or children or even teenagers can access the fridge, don't risk it, just put the bottle in a safe cool place.


this is a bit of a guess but if someone had swallowed too much iodine and you had some lithium aspartate handy i would be quickly tipping a lot of it out of the capsules directly down the throat as lithium binds with iodine.


maybe a bit of vit c would also help as iodine is very oxidising


sites on the web say do not induce vomiting in the event of an iodine overdose and give milk


it is available through a chemist here in australia, david craig galenicals 'aqueous iodine solution'.


"isosol" is a aqueous iodine brand sold in the usa, uses ammonia (NH3) rather than potassium iodide, not sure this is a positive change. not recommending it at the moment


shaking the bottle of diluted iodine just before using is important to distribute the iodine evenly in the water


iodine requirements vary i think especially with things like sweating and how replete other thyroid cofactors are like tyrosine, so i think iodine is going to be a bit individual. be aware the the houstonni enzyme no fenol improves tyrosine levels as does copper sebacate and these will amplify thyroid action and also antiviral action through the pathway from tyrosine to endorphins to t cells.


----------------


from a message board by david derry


"The "test" of putting iodine on the skin to watch how fast it disappears is not an indicator of anything. The iodine disappearance rate is unrelated to thyroid disease or even iodine content of the body.(1-2) Meticulous research by Nyiri and Jannitti in 1932 showed clearly when iodine is applied to the skin in almost any form, 50% evaporates into the air within 2 hours and between 75 and 80 percent evaporates into the air within 24 hours. (1) A total of 88 percent evaporates within 3 days and it is at this point that the evaporation stops. The remaining 12 percent that is absorbed into the skin has several fates. Only 1- % of the total iodine applied to the skin is absorbed into the blood stream within the first few hours. The rest of the iodine within the skin (8-11%) is slowly released from the skin into the blood stream."


-------------------


iodine used in this way is such a good even stimulant that you need to not use it five to seven hours before bed, that is you will be ready for bed about 5-7 hours after the last application.


loss of iodine in sweat is very significant   taiwan soccer study


loss of iodine is a constant proportion of sweat   the stability of iodine in human sweat


i think iodine is very individual and people will have to work out for themselves what they need, like someone i know on the same dilution has increased their daily iodine to four drops and says that she has improved on the higher dose


being temporarily hyperthyroid is not necessarily a bad thing as you get enhanced immune and anti cancer activity (though sleep gets broken), but if you use lithium aspartate as per my web page 'lithium' and stop taking the iodine then the hyperness comes down.


i really would be cautious of using a more intense solution regularly because iodine is quite destructive to living cells. this is my preferred way of supplementing iodine and i don't recomend kelp for iodine because of digestibility/scd issues with kelp and the unfortunate probability of the kelp coming from polluted coastlines. kelp also appears to have high levels of arsenic and bromine.


with a kid you might want to dilute it further, say 75ug a drop or use a very small drop, but basically i put it on the underside of the forearm and rub it over as large an area of the underside of the forearm as it will spread to........ (person it is going on has to do this) and it is absorbed slowly though the day which is what suits best i think. it has an enervating effect so use it say late morning or lunch to match rising daily thyroid levels and u will get the hang of it. if you put it on too early in the day it sort of jangles the natural thryoid cycle.


the antiseptic 'hexal povidine iodine' which is very effective and also useful for things like tinea and other fungal problems has signficant amounts of iodine absorbed from it by the body. 11th march 04, several days ago i put a large amount of povidine on what i thought was a fungal infection on the skin but turned out to be flea bites (which msm cured) and am really regretting it as i think i absorbed a lot of iodine and this has put me out of sorts. so you have to watch that you only use small amounts over a small area.


iodine is a poison so please keep bottles out of the reach of children. a bottle or part bottle can be fatal if swallowed and its a very unpleasant death by all accounts. you also have to be careful of splling drops of undiluted iodine on yourself as 2.75mg is a very signficant amount of iodine and may cause temporarily high thyroid.



a search on the web indicates a lethal dose is about 2000 milligrams (2 grams) of molecular? iodine



KI or potassium iodide is suppsed to be a lot less toxic



the danger of radioactive iodine is that the body will absorb it from the air causing thyroid cancer.............. so it pays to keep thyroid iodine levels adequate to reduce this uptake. radioactive iodine can come from nuclear testing or fallout, a nuclear power accident or a terrorist attack. in the event of a nuclear power accident , terrorist attack or nuclear explosion you need to be able to apply and ingest say several mg or more of iodine immeadiately.



the other thyroid minerals are manganese, zinc, copper, magnesium, selenium and possibly chromium, you need to work on the synergy of these in conjunction with iodine and don't forget lithium as above to spread the iodine in the body. see 'minerals i take' in the index for the forms and amounts of cofactor thyroid minerals



adequate thyroid is a key because it drives the immune system and is instrumental is catching cancer and the facilitiating vitamin a metabolism


the supposed test for iodine deficiency by painting a few drops of intense iodine solution on the skin and seeing how long it takes to disappear is crazy, the mechanism is diffusion and the rate of disappearance does not relate to body stores


however it may have some validity for very high (read toxically high) daily doses of iodine, like oral 50mg to 75mg daily where there is some tissue saturation of iodine and the disappearance rate with skin applied iodine may slow with high iodine levels in cells.


but you don't want to be in that area, far, far better to use very much lower doses of iodine with selenium, magnesium, manganese, chromium and other minerals that work with iodine to promote thyroid function.


a post by laurie on the yahoo adult metal chelation board (19th august 2005)

"I don't agree with the iodine test either. I had the skin painting iodine test done and I could still see the iodine one week later indicating no need for iodine. My urine test indicated I was low in iodine though. I don't believe either of the tests."













an enzymesandautism post 11th april 04


i think iodine has a strong anti viral action , for example the hypoiodous (HIO) form of iodine inactivating polio viruses by interfereing with the protein coat of the virus.

"Our results indicate that when HIO was the inactivating agent, the ability of the viruses to adsorb to host cells was impaired. Since the percent inactivation values correlated well with the percent reduction in adsorptive capabilities, we suggest that HIO reacts with the protein coat of the virus and not with the RNA. This proposal is in agreement with the findings of Hsu, who reported that poliovirus and phage f2 RNAs are fully resistant to iodine (13). The reactions of HIO with the protein coat of poliovirus appear to be oxidative rather than substitutive since we found no evidence of 1251 binding to polioviruses. Iodine has been shown to act on other proteins and viruses by oxidation of sulfhydryl groups, which results in little or no binding of the halogen"

from mechanisms of inactivation of poliovirus by chlorine dioxide and iodine

maybe low iodine is a cause of polio?

so i am trying one drop of iodine of diluted lugols every one or two days. i am not keen on iodine in kelp tablets.

iodine needs balancing with lithium as per the lithium web page or you will end up with sleep problems.

it seems best put on from about 10-11 in the morning, to early and it jars with the natural low in the thyroid cycle first thing in the morning and to late and it is to enervating in the evening.














from an enzymesandautism post


P.S. The article says to apply it at night but you say it's enervating. How many hours would it be active for? TIA Prue


my reply:


what i find is its best put on in the morning as per my web page, but it does seem to be quite a slow release that way.

it does seem to take a while to work its way into the thyroid hormones i am putting it on once every two days at the moment, thats a drop diluted to about 400 mcg of iodine

lithium is like a pump for iodine and pumps it through the system and also out of the body i think which is quite good in a way

high levels of fluoride displacing iodine and leaving women low iodine is one of the reasons for todays epidemic of breast cancer i think













the amount of iodine needed on a daily basis may vary considerably based on wether there are iodine inhibitors in food and possibly (in the usa) perchlorate in the water.

"Perchlorate binds to, and blocks, receptors for the movement of iodine from the bloodstream into the thyroid. This will reduce the movement of iodine into the thyroid."

the thyroid hormones direct brain development, hugely significant in the intelligence of the developing foetus.


thiocynate in cruciferous vergetables (broccoli, brussel sprouts, cabbage), cigarette smoke, cassava(arrowroot - also scd illegal) is a potent inhibitor of iodine uptake

nitrate in leafy vegetables is less potent but can be in such large amounts that it is a signifcant iodine uptake inhibitor

and also perchlorate in some vegetables depending on where grown (parts of south america?)

so depending on the dietary patterns the amount of iodine can vary considerably. i ran into this problem eating a bit of cabbage over a while, felt a significant decline in energy that was remedied by more iodine (also cut back on cabbage)




---------------------




from a sheep study, iodine is very important for fertility and adequate breast milk iodine content




Iodine supplementation restores fertility of sheep exposed to iodine deficiency.


Ferri et al, Teramo, Italy.




The aims of the study were to monitor sheep iodine intake in different sheep breeding farms in Abruzzo and to evaluate the effects of iodine supplementation on ovine fertility. The urinary iodine concentrations (UIC) in animals of 8 out of the 11 breeding farms analyzed were borderline (UIC 100-150 microg/l) or very low (UIC < or = 50 microg/l). Only animals bred in 3 farms showed an adequate iodine intake with a mean UIC > or = 300 microg/l. Animals with very low iodine intake had lower T4 and T3 (p < 0.01) serum levels, compared to those with adequate iodine intake. To investigate the effects of iodine supplementation on ovine fertility, 32 ewes and 20 rams, characterized by low UIC, were randomly divided into 2 groups. One group (16 ewes and 10 rams) received a sc injection of 1 ml of Lipiodol, containing 480 mg of iodine, while the remaining animals were employed as control. This treatment was able to maintain UIC above 300 microg/l for 3 months and to increase T4 and T3 serum levels (p < 0.01). After 9 months, the fertility of control and treated animals was assessed by monitoring the rate of successful matings by ultrasonography.

The results showed that 100% of treated ewes mated with treated rams were pregnant vs 37% of the control ewes mated with control rams (p = 0.007). The iodine content was 4-fold higher in milk from treated ewes (2393 +/- 453 microg/l), compared to controls (675 +/- 154 microg/l). The results demonstrated that iodine supplementation restores fertility of sheep living in iodine deficient areas and may represent a means to achieve a silent iodine prophylaxis of local populations.




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Local blood flow in the dorsal hippocampus and cerebellar cortex in progeny of iodine-deficient rats.


Gabrichidze GO, Lazrishvili NI, Metreveli DS, Bekaia GL, Mitagvariia NP.


Experimental studies show depressive behavior in rats caused by hypothyroidism and antidepressant effect of thyroid hormones. The present study analyses changes in the hippocampal and cerebellar cortex local blood flow in the progeny of rats suffering from iodine deficiency before mating and during the whole period of gestation. The diet with very low iodine content results in a decrease of local blood flow in both brain structures, but the greatest changes were observed in hippocampus. Addition of the iodine to the diet eliminates the above blood flow changes.




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THE CHOROID PLEXUS, CILIARY BODY, ALZHEIMERS, AMD, GLAUCOMA AND IODINE



both the choroid plexus in the brain and the ciliary body in the eye contain fluid with iodine that help break down the amyloid plaques

so alzheimers, glaucoma and amd are probably really iodine deficiency

the choroid plexus filters out beta amyliod proteins, and also probably the ciliary body in the eye performs a similar function on the drusen plaques that form in amd (age-related macular degeneration)

amd is "the alzheimer's disease of the eye," in that both disorders involve the aggregation of misfolded amyloid proteins and metals like zinc and copper into microscopic clumps called plaques.

now the interesting thing about the choroid plexus is that it has quite a high iodine level (don't believe the medical crap about only the thyroid needing iodine) - and also the ciliary body has iodine - so i wonder if alzheimers and amd are in large part due to iodine deficiency or antagonism and maybe this is also a mechanism for the cretinism of iodine deficiency

i bet high mercury and low iodine have a push-pull depreciating effect on the choroid plexus and ciliary body function

the protein beta-amyloid, which causes the so-called "plaque" lesions in the brains of alzheimer's patients, also leads to nerve cell death in the retina. this is a clear link between what causes alzheimer's disease and one of the basic mechanisms behind glaucoma

alzheimer's can be diagnosed by looking at the retina for nerve cell death

"the retina is actually an extension of brain tissue, travelling down the optic nerve into the back of the eye, opticians have been routinely looking at the brain in a more direct way than has been possible by high tech brain scanners such as mri and cat" - Dr Francesca Cordeiro

with the explosive use of fluoride (halogenic precedence iodine displacer), chlorinated swimming pools and enviromental and food borne bromine in the past forty years its no wonder that intelligence is downsizing to make ronald macdonald look like einstein, george bush look like knowing what he is doing and oprah a saint............(yes the first billionare saint, but hey thats a billion reasons why she's a saint)

bet ian thorpe (famous australian swimmer who was becoming cfs when this was written - 2006/2007) is getting his brain downsized by beta amyloids


"The choroid plexus in the brain takes up iodide; the choroid plexus manufactures cerebrospinal fluid and transthyretin, a protein that transports both Vitamin A and T3 in the brain. The CSF normally contains iodide, probably for purposes of defense." - catherine tamaro



------------------



web quote

"Researchers have discovered that an organ in the brain called the choroid plexus apparently plays a critical role in preventing the accumulation of a protein associated with Alzheimer's disease.

The researchers found that the choroid plexus acts as a sort of "fishnet" that captures the protein, called beta-amyloid, and prevents it from building up in the cerebrospinal fluid, which surrounds and bathes the brain and spinal cord. Moreover, tissue in the organ is able to soak up large amounts of the protein and may contain enzymes capable of digesting beta-amyloid, said Wei Zheng (pronounced Way Zsheng), an associate professor in the School of Health Sciences at Purdue University.

The findings represent the first time that researchers have identified the potential existence of a natural mechanism in the brain for removing beta-amyloid.

"This newly uncovered pathway may help explain how normal brains balance this protein and how an imbalance caused by aging, genetic or environmental factors may lead to or worsen Alzheimer's disease," Zheng said.

Researchers had already known that the cerebrospinal fluid in the brains of Alzheimer's patients contains abnormally high quantities of beta-amyloid fragments. Beta-amyloid deposits accumulate over a period of years, resulting in abnormal clumps, or plaque, typical of Alzheimer's disease. Scientists do not yet know whether the disease is caused by the plaque formations or beta-amyloids themselves.

The discovery suggests that a malfunctioning choroid plexus could allow too much of the protein to build up in the brain.

Findings are detailed in a research paper written by postdoctoral research associate Janelle S. Crossgrove, postdoctoral fellow G. Jane Li and Zheng, all in the Purdue School of Health Sciences. The researchers will be honored on April 2 with a best paper award from the Society for Experimental Biology and Medicine.

Scientists do not know how beta-amyloid is deposited in the brains of Alzheimer's disease victims, but a long-held theory is that the protein is overproduced by aging brain cells, or neurons.

"We are coming from a totally different point of view," Zheng said. "We think that a balance of beta-amyloid is maintained partly by the choroid plexus, which removes beta-amyloid, and that this balance breaks down, leading to a buildup."

The majority of Alzheimer's research has historically concentrated on how the brain produces beta-amyloid protein, but the new findings point to the possibly critical importance of the "garbage-removal" process in the choroid plexus, Zheng said.

"We think the choroid plexus plays a role of removing all the garbage, including the beta-amyloid," Zheng said.

The research focused on how the choroid plexus works to clean beta- amyloid from the cerebrospinal fluid. Studies using rat brains indicated that choroidal cells removed about five times more beta- amyloid from cerebrospinal fluid compared to how much of the protein the cells allowed to pass into the fluid.

"These results appear to tell us that a healthy choroid plexus can remove beta-amyloid from the cerebrospinal fluid, suggesting a novel pathway for the brain to maintain a normal balance," Zheng said. "Of course, much more work needs to be done to verify this theory."

The researchers also found that the choroid plexus possesses an enormous capacity to absorb beta-amyloids. The findings support the theory that the choroid plexus may possess a special enzyme that breaks beta-amyloids into smaller pieces, making it possible to soak up large quantities of the protein.

"The tissue must have a unique mechanism that is different from brain cells, something that enables it to chop up these beta-amyloids," Zheng said.

Future research may focus on efforts to isolate possible enzymes.

Zheng said the findings suggest that aging may degrade the organ's performance, and it is also possible that lead poisoning might increase the risk of Alzheimer's disease by damaging the choroid plexus and reducing its ability to filter beta-amyloids."




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TOXINS IN FISH INTERFERING WITH THYROID PROCESSING ENZYMES



"Regulation of thyroid function of fish with particular emphasis on the conjugation and deiodination processes which regulate the activation and inactivation of thyroid hormones in blood and tissues. I have interest in the effects of heavy metals (Hg) and PCBs on the enzymes involved in conjugation and deiodination in liver and brain. Thyroid hormones are required for development, growth and aspects of sexual function in fish. Hence substances that modify thyroid function may influence these processes."


my comment:


if only it were just pcbs's, but seafood and most freshwater fish have a highly synergistic accumulation of organic toxins that makes the eating of them problematic.




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E. COLI INITIATING AN AUTOIMMUNE RESPONSE AGAINST THE THYROID



The thyroid hormones may share an amino acid sequence with e coli, thus you may get an innate immune response against them if the immune system is a bit wonk, and this would be recursive for low and high iodine

-----------

Evidence for a potential common T-cell epitope between human thyroid peroxidase and human thyroglobulin with implications for the pathogenesis of autoimmune thyroid disease.McLachlan SM, Rapoport B. Department of Medicine, University of Wales College of Medicine, Cardiff.

In order to explore the possibility that, in autoimmune thyroid disease, anti-thyroglobulin (Tg) and anti-thyroid peroxidase (TPO) antibodies arise concurrently because they share a common T-cell epitope, we performed a detailed comparative analysis of the cDNA nucleotide sequences corresponding to these two genes. We discovered an 8 amino acid region (Leu-Ser-Glu-Asp-Leu-Leu-Ser- Ile in human TPO) in which there were 6 identical and 2 conserved amino acid residues when compared with human Tg. This remarkably similar region is near the amino-terminus of human TPO (residues 119-126) and the carboxyl-terminus of human Tg (residues 2763-2770). A second feature of interest was that this region of homology conforms to the Rothbard algorithm for a T-cell epitope. Third, probing of the Swiss-protein data bank (10,008 proteins containing 2,952,765 amino acids) with the human TPO region revealed greater homology for human Tg than for any other eukaryotic protein. Two bacterial proteins (E. coli aminopeptidase N and stringent starvation protein) had higher homology scores from human TPO than did human Tg. Our findings provide circumstantial evidence that human TPO and human Tg, and possibly certain bacterial proteins, do indeed share common T-cell epitopes that may play a role in the pathogenesis of autoimmune thyroid disease.

-----------

my comment:

i think adequate iodine and thyroid must be important for immune system function and differentiation so that with adequate iodine the immune sytem is better able to avoid erronous reaction to thyroid hormones, you would get a similar issue for large amounts of iodine also reducing thyroid function




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EVIDENCE THAT UNDIGESTED FOOD PARTICLES GETTING ACROSS A LEAKY GUT CREATE AUTOIMMUNE ISSUES



paul writes:


"Flechas told me I was barking up the wrong tree trying to reverse Hashimoto's with iodine. That's when he suggested the Betaine and phosphaditylcholine to lower the antibodies. Mine dropped from 96 to 42 and hopefully further next test."



another posters comment:


Flechas said when he monitors antibodies they usually don't change with iodine supplementation



paul writes:


Betaine is a methyl donor.


http://www.raysahelian.com/methyl.html


The foods richest in phosphatidylcholine, the major delivery form of choline, are beef liver, egg yolks and soya. Beef liver, iceberg lettuce, peanut butter, peanuts and cauliflower are some foods that contain free choline. Choline is a precursor for phosphatidylcholine, sphingomyelin, acetylcholine AND the methyl donor BETAINE. This phosolipid makes up 8 % of of cell membranes and is found in great quantity in the thyroid. It has a rejuvenating effect on the liver also.


http://www.clltopics.org/CellBio/Epigenetics.htm
http://cat.inist.fr/?aModele=afficheN&cpsidt=16003455


Just be aware that some think that therapeutic dosing of methyl donors like betaine may switch off unintended genes such as tumor suppressor genes at the same time.



my comment:


betaine increases stomach acid and phosphaditylcholine is an essential fatty acid important for cell junction seal and cell wall permeability, so it seems reasonable to infer that undigested or partly digested food particles getting across a leaky gut raise thyroid antibodies, and allergies/autoimmune response generally


methyl donation reduces homocysteine and autoimmune/immune response generally


also see "e. coli initiating an autoimmune response against the thyroid" in the section just above.


note: duplicated in scd_starting_enzymes



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IODINE CONCENTRATES IN THE GALLBLADDER



"How is an oral cholecystogram (OCG) done?

The patient takes iodine-containing tablets by mouth for one night or two nights in a row. The iodine is absorbed from the intestine into the bloodstream, removed from the blood by the liver and excreted by the liver into the bile. The iodine, together with the bile, is highly concentrated in the gallbladder. Iodine is used in an OCG because it is dense and radioopague (stops x-rays). It outlines the gallstones that are radiolucent (x-rays pass through them) and that are usually invisible on x-ray.

The bile ducts themselves cannot be seen on the x-ray in an OCG because the iodine is not concentrated in the ducts. Therefore, any gallstones lodged in the ducts will go undetected on OCG. Failure to visualize the gallbladder on an OCG may occur for one of two reasons. First, a gallstone may have obstructed the cystic duct and prevented the iodine-containing bile from entering the gallbladder. Second, inflammation of the gallbladder -- usually due to gallstones -- may have interfered with the gallbladder's ability to concentrate bile and iodine. Whichever the cause, failure to visualize the gallbladder on an OCG strongly suggests a diseased gallbladder."


my comments:

and that its highly concentreated in the gall bladder, would help keep the gall bladder sterile

no biofilm forming in the gall ballder, probably similar for the kidneys and kidney tubules as well

iodine would help keep yeast out of the bile duct

since the bile goes into the intestine it would help sterilise the intestine to



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IODINE DOSING FOR GASTRIC MUCOSA



click on    Dr. Sebastiano Venturi


then go to


"Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach 2000
S.Venturi, F.M. Donati, M.Venturi, A.Venturi, *L.Grossi and **A. Guidi
LINK"
and click on the link


there is sometimes a particularly annoying blinking ad at the top of the page, just zoom in on it (right click over the ad) until it comes up very large and it stops blinking


when will the advertisers figure that making the readers want to shoot them is not the way to give a good impression of their product?


anyway


half way down that page is a human scintigram of some radioactive iodine injected into a woman


its a little hard to guess the way it decays from the body cauae of the short half life of the radioactive iodine but it looks to me like it is better to take a small amount of iodine before each meal to optimise gastric mucosa loading as it leaves the body or is grabbed by the thyroid fairly quickly


i woudl infer the iodine is readily excreted and also that a lot in the mucosa etc eventually ends up in the thyroid, so you don't have to worry about the thyroid picking up iodine, it takes it from everything else


the same may apply to the gall baldder and lungs, wether you would get any propylactic benefit against viruses by a small dose before likely viral exposure i don't know


and wether it would be useful for ulcerative colitis i don't know either, but i would say there is a possibly it is helpful




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CHLORINE AND IODINE DON'T MIX



"Formation of iodoacetic acids during cooking: interaction of iodized table salt with chlorinated drinking water. Becalski et al, Health Canada


Iodoacetic and chloroiodoacetic acids were formed when municipal chlorinated tap water was allowed to react with iodized (with potassium iodide) table salt or with potassium iodide itself. Iodoacetic acid was recently shown to be a potent cytotoxic and genotoxic agent. For analysis, samples were extracted with t-amyl methyl ether and converted to the corresponding methyl esters using methanol and sulfuric acid. The concentration of iodoacetic acid was determined by gas chromatography-mass spectrometry (GC-MS) using an authentic standard. The identities of iodoacetic and chloroiodoacetic acids were further confirmed by gas chromatography-high-resolution mass spectrometry (GC-HRMS). Certain influences of sodium hypochlorite and humic acid as well as the concentration of potassium iodide on the yields of these acids were investigated. The concentration of iodoacetic acid in tap water samples boiled with 2 g l-1 of iodized table salt was found to be in the 1.5 microg l-1 range, whilst the concentration of chloroiodoacetic acid was estimated to be three to five times lower."




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THE THYROID AND VIRUSES



  “ Subacute thyroiditis  is an uncommon condition thought to be caused by viral infection of the thyroid gland. The condition  (ed. swelling of the thyroid gland)  often occurs after a viral infection of the upper respiratory tract. Mumps virus, influenza virus, and other respiratory viruses have been found to cause subacute thyroiditis ”


  “ Subacute thyroiditis: Symptoms of thyroid hormone excess (hyperthyroidism) such as nervousness, rapid heart rate, and heat intolerance may be present early in the disease. Later, symptoms of too little thyroid hormone (hypothyroidism) such as fatigue, constipation, or cold intolerance may occur. Eventually, thyroid gland function returns to normal Spontaneous improvement is the rule, but the illness may persist for months ”


---------------


andrew:


i have had a virus this weekened (august 06) that seems to have an unusually strong impact on the thyroid making me feel tired and sleeping a lot.


I have been taking a lot of retinyl acetate which helps but also using a lot of iodine as per applying to the underside of the fore arm and still i seem to need more iodine.


i can only assume that the thyroid hormone is being destroyed in some way by this virus or thyroid hormone production impaired or my immune response to the virus is having some similar effect.


----------


Lymphocytic choriomeningitis virus can persistently infect thyroid epithelial cells and perturb thyroid hormone production. LS Klavinskis and MB Oldstone


"Although viral infection has been suspected as the cause of some thyroid disorders, there has been limited data to support this contention seriously. Now we report the first evidence that lymphocytic choriomeningitis virus can persist in the thyroid gland, particularly thyroid epithelial cells in which thyroglobulin (Tg) the precursor of thyroid hormone, is synthesized. Concomitant with the infection of these cells is a significant reduction in Tg mRNA and in the level of circulating thyroid hormones. Another virus (lactate dehydrogenase virus) that causes persistent infection but does not replicate in the thyroid gland failed to alter levels of circulating thyroid hormones. These observations in an experimental model support the hypothesis that viruses may account for some thyroid disorders in man. "


---------------


The author experienced a case of subacute thyroiditis (de Quervain) in a 36-year-old female. Electron microscopic examination of the thyroid tissue of the patient revealed virus-like particles (VLP) in the degenerated follicular epithelium Judging from the size, the VLP corresponded to the influenza or mumps virus. (m. sato 1975 study)


Hmm.... a case for Not having the flu vaccine? (eileen's comment)


Subacute thyroiditis (SAT), also called de Quervain thyroiditis or granulomatous thyroiditis, is a self-limiting, possibly viral, and inflammatory thyroid disorder that is usually associated with thyroid pain and systemic symptoms. This report details a case of SAT possibly associated with influenza vaccine (Vaxigrip(R)) in a young female


my comment:


intersting flu proteins must go to the thyroid, maybe the flu is trying to supress the thyroid to keep the body from mounting an adequate immune response to it


eileen says:


apparently there are forms of infective bacterial and fungal thyroiditis too, but its supposed to be rare



----------------------------------



if you wash and dry the undersides of the forearms and put a drop or two on one , then rub the undersides of the two forearms together it seems to make for a slow release of the iodine that is even during the day


microdoses of solaray lithium asparate like about 250 mcg (micrograms NOT milligrams) several times a day help spread iodine internally and more can be taken to ramp down the iodine if too much is used


a big trap with liquid iodines is the iodine evaporates fairly rapidly out of even closed bottles over several weeks you you have to keep topping up with stronger solution



-----------------



why i am able to use much higher levels of iodine (september 06)


did a heap of idoine yesterday morning and am feeling 'non viral' now


i think my being able to apply more iodine without going hyper is due to the metafolin and not eating fish, prawns or shellfish


arsenic is a selenium antagonist and inhibits selenium uptake into the thyroid


i think that arsenic inhibits the conversion ot t4 to t3 and also heavy metals generally do this so you end up with complexed high and low thyroid


so am getting better t4 to t3 converison and also less rT3 (reverse t3) so that effectively i am getting more thyroid hormone into my cells for use


the frequent microdose lithium aspartate will be important to



-----------



increasing T4 to T3 conversion by supplementing selenium, magnesium and metafolin and being able to apply heaps more iodine is strongly anti viral


but getting that better T4 to T3 conversion may take a while


i think that the thyroid hormones are more significant in viral resistance than appears


supplementation to promote full biochemical chain thyroid function strongly helps viral resistance


thyroid issues seem to be strongly associated with gut issues from my observation of the yahoo iodine message board, in part because of reduced blood circulation to the intestine and stomach?


women need a lot more iodine than men for the breasts, the breasts are replete in iodine, presumably because of the importance of iodine to the developing infant.


human babies are not born with iodine stores, like say rabbit kittens, they are dependent on iodine from breast milk to fuel their growing bodies




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EATING ANIMAL THYROIDS



people used to eat thryoids all the time, especially in sausages, but i think thyroids go for pet foods and not human consumption now, not sure about this tho, probably varies


thyroid organs contain thyroid hormone  (T4 to T3 ratio of aprox 4.2 for pigs? - armour?)  iodide, iodine, possibly bromine, and all the mineral and amino acid/protein cofactors


too much can send you off your scone, a 1/3rd? of a gram of australian possum thyroid  (one lobe)  can keep me high for days


the feral animal thyroid lobes i have tried  (australian possum and wallaby)  have a balanced effect, with a T4 half life of about 2˝ - 3 days, wallaby thyroid is nothing like as good as australian possum thyroid, though the "potaroo" thyroid can be ok


thyroids from female animals are better than from male and younger is better than older tho i avoid adolescent animals


old male animal thyroids should be entirely avoided, and probably old female animal thryoids as well


____________________



apparently freezing wild/game animal does not kill trichinosis, but freezing domestic pork for 20 days @ -15C or 3 days @ -20C is supoposed to kill the cysts


the problem is home freezers may be very much less than these temperatures


putting some 35% hydrogen peroxide in the freezer (it remains liquid at low temperatures) and then using a digital thermometer is a good way of measuring freezer temps, my small stand alone freezer measured - 12.2C, the freezer on the bottom of the fridge measured -11.9C with the compressor running


whereas raising the temperature to 62C/144F kills them


the nutritonal value of thyroids does seem to be basically preserved by freezing, but i prefer fresh


i would say you always have to cook thyroids a bit, i do about a minute to two shallow pan fired/steamed


____________________



there seems to be quite a variability in when the hormone hits after eating, from 4 to 11 hours, so basically they need to be eaten first thing in the morning or you will stay up to 4 am :o)


viruses seem to have a strong impact on how long this takes, if you are viral it can take 11 hours


because i eat a lot of fat, i find i still need to take oral iodine tincture, even with eating a thryoid, even though i may drop a drop


also thyroids may vary considerably in the amount of iodine they contain


i think that we are designed to eat thyroids occasionally and this replacement of our thyroid hormones with ingested animal thyroid hormones enables our own thyroids to be shut down and self repairing to occur


it is a bit of a rough process eating an animal thyroid and you have to be very careful of amounts, you can literally be on rocket fuel for several days


cattle or cow thyroids don't really work for thyroid replacement, most likely pig (porcine) is best


thyroids seem to retain activity if frozen


organic pig thyroids are likely better than armour, however i think to ensure parasites are killed you have to gently lightly fry them, a small amount of water with the fat in the frypan will keep the temperature down to 100C or lower


thyroids are chewy!  you need good teeth


there is quite a high metabolic cost in making thyroid hormones, cats, who on a feral diet have a constant supply of exogenous thyroid hormones, have evolved to only make a minimum of their own


medical pig/porcine thyroids or synthetic thyroid medications are not a substitute for having your own thryoid working properly, there is an intrinsic dissonance with externally supplied thryoid hormone and a very noticable cognitive impairment in those on medical thryoid hormone (compared to their own thryoid's working - of course the cognitive impairement of low iodine and low thryoid is horrific)


the american attitude of no care about thyroid nutrition, dietary goitrogens, enviromental toxins or mercury from amalgam fillings, and just go on thryoid hormone like it's of no consequence to lose your own thryoid function, is particularly trashy


in the usa there is an issue with enviromental radioactive iodine and i sure would not be eating buffalo thyroids from nevada, texas may be ok


__________________



i think the compendium and bcd in conjunction with eating feral thyroids strongly promotes thyroid healing


squirrel thyroids in the usa? skunk? coyote? course birds have thyroids to, u would have to look a bit at what they were eating


the australian possum thyroid is outstanding, wallaby is ok and thats all i have tried


armour is from factory raised pigs and doesn't have a lot of t3 in compared to what the body is potentially able to convert itself from t4, mainly in the liver and kidneys, but also in other tissues via the selenium dependent deiodinase enzymes


type 1 deiodinase is most prominent in the liver, kidney, thyroid, and brain, type 2 deodinase is located prominently in the brain, pituitary, thyroid, muscle, heart and placenta  endocrinology and metabolism


i think the feral thyroids offer a better cross section of nutrients the thyroid needs and the thyroid has to be put in a low hydrogen peroxide generating rest state to allow repair and humans evolved in an enviroment where this was occuring with their consumption of offal and actually used to occur until recently with thyroids being incorporated into sausage meat


i feel much better for eating feral thyroids occasionally and not just have them in a broth, there is a need for eating thyroid that can't be got around


on the other hand eating them too frequently can also be a problem, i wouldn't eat more than one a fortnight on average, though if you are on armour, you are already eating thyroid daily


__________________



eileen (august 28th 2008) writes:


Cattle thyroid or neck sweetbread  as my butcher called it.


I ate some yesterday for lunch, Lightly panfried with some vegies and served with sour cream and lemon juice squeezed over it all


Went down well ;o) the thyroid was quite tender in texture (did cook it very carefully, not overdone)


I had a bit too much I think as I got a real zing from it shortly after eating and felt a bit too buzzy/flicky and even vision affected for a while and then at 5pm felt soporific but wired at the same time for about 3/4 of an hr


I had a piece about 1x2 inches and will try a much smaller piece in about 2 or 3 days time and see how that goes


They are quite large but the treasure of a butcher I frequent eats them too (no wonder he's so vigorous despite not being young) and says they freeze well.




Andrew asks: you eating much cattle thyroid?



Eileen replies: not a lot but a bit on a regular basis, once a week always occasionally twice; its something i'd forgotten to factor into reasons i feel pretty good long term these days (minus viral times)


_________________



i eat quite a bit of fresh fat and i am of the opinion that ancestrally high fat diets also included thyroids, so i get hold of animal thyroids and cook and eat small bits regularly


very small amounts of topical iodine help but it's not enough, one needs to touch base with our evolutionary requirements which are the actual eating of thyroids


thyroids used to be in sausages but it's not clear to me that they still do this as offal seems to go into pet food now



did you know



ravens just don't pluck out the eyes , but they reach their beaks down through the skin from under and along the jaw and eat the thyroids?



no



wonder



they



are



so



   energetic !








 

SELENIUM AND IODINE NEED TO BE IN RATIO



when thyroid hormones are made in the thyroid, its a fairly oxidising process with the generation and use of hydrogen peroxide to organify iodine


selenium is needed to make glutathione to neutralise excess hydrogen peroxide and the free radicals generated and in fact, without adequate selenium-dependent glutathione peroxidase you will get an increasing number of antibodies to the thyroidal protein fragments created  study


if you have too much selenium with respect to iodine you reduce the amount of thyroid hormone made


if you have too much iodine with respect to selenium you get oxidative damage to the thyroid from high levels of H202 and the development of autoimmunity antibodies


there is an absolute limit on how much iodine you can take because the amount of selenium necessary to offset the H2O2 production also starts to interfere with the sulphur based enzymes in the thyroid


excessive iodine deprecates mRNA levels of the type 1 deiodinase (D1) in the liver, kidney and thyroid, the right amount and types of selenium aka the compendium help offset this (pmid: 18095564, sept 2007)


so its looking like iodine has a fairly narrow window of application intensity and it will need to be coupled with selenium supplementation amounts similar to what is in my compendium


the useful window of iodine is probably about 1 to 3 mg daily total, but there may be some benefit in short periods like several days of higher supplementation @ 12 -24 mg which should take you to the point of thyroid stress and reduced thyroid hormone production which will make you sleepy


the above is on my weight of 115 lbs and adjustments for weight would need to be made


the very high doses used by some on the yahoo iodine message board like 50 to 75 mg daily for months are indicative of no thyroid function at all, and if you look at these people they are on replacement thryoid hormones and their thyroid's may never recover


it may be sufficient to start on both iodine and selenium together, if you are beginning supplementation, maybe a day or two of my dual selenium protocol first


in fact iodine supplementation will also increase the need for manganese and possibly chromium


rat studies on selenium and iodine are muddied by them using selenite as a selenium source rather than my dual selenium protocol and rat thyroids work differently


___________



"Dietary Selenium Intake Modulates Thyroid Hormone and Energy Metabolism in Men"


Wayne Hawkes, Nancy Keim


U.S. Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center and Department of Nutrition, University of California at Davis, Davis, CA


Most studies of selenium and thyroid hormone have used sodium selenite in rats. However, rats regulate thyroid hormone differently, and selenite, which has unique pharmacologic activities, does not occur in foods. We hypothesized that selenium in food would have different effects in humans. Healthy men were fed foods naturally high or low in selenium for 120 d while confined to a metabolic research unit. Selenium intake for all subjects was 47 µg/d (595 nmol/d) for the first 21 d, and then changed to either 14 (n = 6) or 297 (n = 5) µg/d (177 nmol/d or 3.8 µmol/d) for the remaining 99 d, causing significant changes in blood selenium and glutathione peroxidase. Serum 3,3',5-triiodothyronine (T3) decreased in the high selenium group, increased in the low selenium group, and was significantly different between groups from d 45 onward. A compensatory increase of thyrotropin occurred in the high selenium group as T3 decreased. The changes in T3 were opposite in direction to those reported in rats, but were consistent with other metabolic changes. By d 64, the high selenium group started to gain weight, whereas the low selenium group began to lose weight, and the weight changes were significantly different between groups from d 92 onward. Decreases of serum T3 and compensatory increases in thyrotropin suggest that a subclinical hypothyroid response was induced in the high selenium group, leading to body weight increases. Increases of serum T3 and serum triacylglycerol accompanied by losses of body fat suggest that a subclinical hyperthyroid response was induced in the low selenium group, leading to body weight decreases.


________



the above study makes a lot more sense, well i was reading the rat studies and it wasn't adding up so i had to drop the studies and think what it should actually be


that would match the extra selenium knocking back to much hydrogen peroxide lowering T4 and T3 production


so low selenium lets to much hydrogen peroxide hang around which makes too much T4/T3 and if you ramp iodine on low selenium you are going to really go hyper


probably damage the thyroid as well from all the hydrogen peroxide which might be a longer term effect than that study


so me getting sleepy on 12/24 mg iodine a day was on higher selenium


__________



* selenium supplementation on low iodine *


"In central Africa, myxoedematous cretinism is prevalent in areas of severe iodine deficiency. These cretins are characterized by hypothyroidism with onset before or shortly after birth, absence of goiter, and progressive thyroid damage and destruction. The severity of cretinism was found to be proportional to the degree of hypothyroidism, but also to be correlated with selenium deficiency. The hypothesis was put forth that defective glutathione peroxidase due to selenium deficiency resulted in lack of protection against peroxidative damage induced by the high levels of H2O2 in the thyroid cell. Glutathione peroxidase activity was found to be decreased in selenium-deficient areas in Zaire and Ubangi, and the enzyme activity in cretins was half the level in normal subjects. Selenium supplementation for 2 months corrected glutathione peroxidase levels in both normal subjects and cretins. However, this supplementation also produced decreases in serum T4 and T3 and an increase in TSH. Selenium supplementation in the cretins, already suffering thyroid dysfunction, produced a further decrease in serum T4. For this reason, the selenium supplementation trial was discontinued, and patients were supplemented with iodine, which resulted in reversal of thyroid parameters. These results suggested that, by decreasing the rate of thyroid hormone metabolism, selenium deficiency could protect against some of the consequences of iodine deficiency. In view of these findings, Contempre et al. stressed the importance of supplementation with iodine before administration of selenium in patients deficient in both of these elements.


"A previous analysis in one individual in whom type I deiodinase levels appeared to be reduced showed a circulating hormonal profile quite similar to that described above for experimental selenium deficiency in rats. In this patient, serum total and free T4 values were elevated, whereas serum total and free T3 results were persistently in the lower half of the normal range. Despite the elevation in serum-free T4, which would be expected to decrease TSH synthesis and/or release (l), serum TSH was 2.2-2.4 mu/liter and TRH response normal or enhanced. In another family studied by Maxon et al., an elevation in total and free T4 was associated in six affected members with high normal total T3 levels and normal TSH. Although this pattern might also be seen in mild generalized thyroid hormone resistance, the elevation in serum T4, (mean 210 nM) was out of proportion to that of serum T3 (2.7 nM), suggesting an impairment in type I deiodinase activity. The fact that in both selenium-deficient rats and in the patients mentioned, serum T4 is elevated whereas serum TSH is normal, implies a role for type I deiodinase in the regulation of TSH. With the present data, it is not possible to determine whether this reduced pituitary feedback sensitivity to T4 can be explained simply on the basis of slightly subnormal circulating T3 concentrations or of a previously unrecognized role of type I deiodinase as a source of locally produced T3 in the hypothalamus or pituitary.


http://edrv.endojournals.org/cgi/reprint/13/2/207.pdf and in my computer files health/minerals/iodine




* high iodine on low selenium has a necrotising effect on the thyroid *



"Dietary Iodine and Selenium Interact To Affect Thyroid Hormone Metabolism of Rats" Christine S. Hotz et al - also has good tables on the effect of iodine on thyroid - http://jn.nutrition.org/cgi/reprint/127/6/1214 - also in my files as 'iodine selenium thyroid rats.pdf'


"selenium deficiency aggravates the necrotizing effects of high iodide dose in iodine deficient rats" b. contempre et al - in my files as 'selenium deficiency necrotising thyroid in high dose iodine in rats.pdf'


___________



a selenoenzyme is essential for clearing T3


so i can see too much selenium, especially methylselenocysteine reduces t3 too much, on the other hand, not enough will make for hyper and leave too much t3 in the system


i could be taking a bit much methylselenocysteine @ 3/4 of a capsule daily. will knock it back to less than 1/2


"Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis. Hernandez et al


The type 3 deiodinase (D3) is a selenoenzyme that inactivates thyroid hormones and is highly expressed during development and in the adult central nervous system. We have recently observed that mice lacking D3 activity (D3KO mice) develop perinatal thyrotoxicosis followed in adulthood by a pattern of hormonal levels that is suggestive of central hypothyroidism. In this report we describe the results of additional studies designed to investigate the regulation of the thyroid axis in this unique animal model. Our results demonstrate that the thyroid and pituitary glands of D3KO mice do not respond appropriately to TSH and TRH stimulation, respectively. Furthermore, after induction of severe hypothyroidism by antithyroid treatment, the rise in serum TSH in D3KO mice is only 15% of that observed in wild type (WT) mice. In addition, D3KO animals rendered severely hypothyroid fail to show the expected increase in preproTRH mRNA in the paraventricular nucleus of the hypothalamus. Finally, treatment with T3 results in a serum T3 level in D3KO mice that is much higher than that in WT mice. This is accompanied by significant weight loss and lethality in mutant animals. In conclusion, the absence of D3 activity results in impaired clearance of T3 and significant defects in the mechanisms regulating the thyroid axis at all levels: hypothalamus, pituitary and thyroid."



-----------------------------------


 

CALCIUM IS A GOITROGEN



Effect of calcium intake on thyroid and renal clearance of iodine in goitre BY H. BHATT. Department of Applied Physiology and Surgical Science, Royal College of Surgeons, Lincoln's Inn Fields, London WC2 3PN - 1977


Goitre due to iodine deficiency is endemic in Southern Iran and the drinking water has a high mineral content. From a group of 120 patients, 20 were selected randomly for this study. Twelve patients were given an oral dose of calcium (as calcium chloride) equal to approximately 20% of the daily dietary intake. 131I was given orally at the same time as the calcium salt, or 1 hr later. The control group of eight patients received tracer 131I only.


The radioactivity due to the 131I in blood, urine and thyroid was monitored at suitable intervals over the next 24 hr. The renal clearance of iodide increased significantly and its uptake by the thyroid was reduced in both the groups given the calcium salt compared to the controls.


____________________



The effects of high calcium intake on the activity of thyroid gland in rats


F. Ebrahimian, S. Zahedi-Asl Department of Physiology, School of Medicine, Ahwaz University of Medical Sciences, Ahwaz, I.R. Iran


The effects of goitrogens on the thyroid gland have been much studied and calcium is considered as a goitrogen in some cases. Since the level of calcium is high in drinking water of some cities of Khozestan province, the effects of high calcium intake on the function of thyroid gland is investigated in this study. For this purpose the concentration of thyroid hormones is measured in rats.


The study was carried out on 73 male and female rats. The animals were divided into 3 groups, control group with normal diet (n=25), group 2 (n=24) consumed diet with high calcium (1 g/kg diet) and group 3 (n=24) had diet with high calcium and iodine (50 µg/kg diet). Animals had free access to diet and water. The rats were decapitated after 1.5 and 3 months, blood samples were collected, centrifuged and the sera were stored at –20°C. Hormones (T3, T4 and TSH) and T3 uptake were measured by radioimmunoassay method, using commercially available kits (Kodak, England). The results indicated that the amount of T3 in the test group was not significantly different from that of control group. The results showed that in the groups which consumed diet containing high calcium and iodide, mean total T4 concentration was significantly higher than control (P<0.05). Measurement of T3 uptake showed that in the test groups, T3 uptake was significantly lower than control. This may be due to increased synthesis of proteins, less hormone synthesis, or abnormality of the protein binding to the hormones. In general the results are predictable with the known concepts.




-----------------------------------


 

MECHANISMS OF CHEMICAL INJURY OF THYROID GLAND



“Many goitrogenic xenobiotics that increase the incidence of thyroid tumors in rodents exert a direct effect on the thyroid gland to disrupt one of several steps in the biosynthesis and secretion of thyroid hormones.


This includes :


1) inhibition of the iodine-trapping mechanism (thiocyanate or perchlorate)


2) blockage of organic binding of iodine and coupling of iodothyronines to form thyroxine (T4) and triiodothyronine (T3) (e.g., sulfonamides, thiourea, methimazole, and aminotriazole, among others)


3) inhibition of thyroid hormone secretion by an effect on proteolysis of active hormone from the colloid (lithium or an excess of iodide).


Another large group of goitrogenic chemicals disrupts thyroid hormone economy by increasing the peripheral metabolism of thyroid hormones through an induction of hepatic microsomal enzymes. This group includes CNS-acting drugs (phenobarbital, benzodiazepines), calcium channel blockers (nicardipine, nifedipine), steroids (spironolactone), retinoids, chlorinated hydrocarbons (chlordane, DDT, TCDD), polyhalogenated biphenyls (PCB, PBB), and enzyme inducers.


Thyroid hormone economy also can be disrupted by xenobiotics that inhibit the 5'monodeiodinase, which converts T4 in peripheral sites (e.g., liver and kidney) to biologically active T3. Inhibition of this enzyme by FD&C Red No. 3, amiodarone, and iopanoic acid lowers circulating T3 levels, which results in a compensatory increased secretion of thyroid-stimulating hormone (TSH), follicular cell hypertrophy and hyperplasia, and an increased incidence of follicular cell tumors in 2-year or lifetime studies in rats.


Physiologic perturbations alone such as the feeding of an iodine-deficient diet, partial thyroidectomy, natural goitrogens in certain foods, and transplantation of TSH-secreting pituitary tumors in rodents also can disrupt thyroid hormone economy and, if sustained, increase the development of thyroid tumors in rats.


A consistent finding with all of these goitrogens, be they either physiologic perturbations or xenobiotic chemicals, is the chronic hypersecretion of TSH, which by receptor-mediated events places the rodent thyroid gland at greater risk of developing tumors through a secondary mechanism of thyroid oncogenesis.”


Capen CC, Department of Veterinary Pathobiology, Ohio State University, Columbus 43210. PMID: 7526405




-------------------


 

BISPHENOL A SUPPRESSES THE TRANSCRIPTION OF THYROID HORMONE REGULATED GENES



this is probably a mechanism that applies to other goitrogens as well


you can see from this that there needs to be a limit on the level of goitrogens consumed, simply promoting thyroid hormone production will have limits, though I2 may have a role in receptor refurbishment


"BPA has been reported to antagonize T3-stimulated transcription of genes in human TSA201 cells at concentrations between 100 nM and 1 microM. BPA recruited the nuclear corepressor to the thyroid hormone receptor. This provides the first evidence for direct effects of low doses of BPA on disruption of thyroid hormone action within cells by competitively displacing T3 from the receptor and by recruiting a corepressor to the thyroid receptor, thus suppressing activation of transcription of thyroid hormone-regulated genes "


BPA leaches from the epoxy resin coating on the inside of cans into food during the heat treatment stage of canning


since it only takes the tiniest amount to affect a fetus, pregnant women would be advised to avoid canned foods


_____________



Thyroid hormone action is disrupted by bisphenol A as an antagonist. (2002)


http://jcem.endojournals.org/cgi/content/full/87/11/5185


Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain. (2005)


http://endo.endojournals.org/cgi/content/full/146/2/607




-------------------


 

MULTINODULAR GOITER AN ANTIBODY ISSUE?



interesting yahoo iodine post, the only way it seems you could get an inflammatory reaction like the rash she writes about is that the nodule is a source of iodine antibodies and the nodule is in fact an antibody inflammation


_________



"I decided to play around with skin painting yesterday. Started out just dabbing Lugol's on skin tags, moles and some dark patches. Since the "equipment" was already out, I then decided to paint the area over my entire thyroid area (I have multinodular goiter, with a large primary nodule in the left lobe).


While there was no reaction anywhere else (face, neck, chest, arms, back), the patch over my thyroid stung like crazy. I noticed the iodine was completely gone from my throat in less than 2 hours. What remained was a red, irritated-looking patch. Guess where? Directly over my primary nodule. Not only that, but the red patch was about the same size as the lobe."


________



this could be because iodine deficiency in the thyroid causes increased oxidative stress and dna mutations


"Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice." j. maier et al. march 2007


lack of iodine in the thyroid can be caused by biofilm toxins impairing iodine uptake by the thyroid, as well as overt dietary iodine deficency and fluoride/bromine displacement.


biofilm toxins compound any damage occurring and its a vicous downwards circle


imo the thryoid is not well designed from an evolutionary point of view, its quite a late add-on in terms of such a basic function (read 'band-aid'), and is demanding in terms of nutritional support and reduced toxin load and needs a good overall level of body biochemistry function


my reading of a stuffed thyroid is that its more than an uphill battle to get recovered function, that is you you need to replace mutated dna on a bad auto-antibody background


BCD and the compendium address's both the dna upgrading and auto-antibody issues


u may need to be on armor which is dessicated pig thyroid or eat feral thyroids occasionally if u can get them to give the thyroid some breathing space to recover by downregulating it's need to produce hormone and organify iodide


low thyroid is like the 'dawn of the living dead', their brains are gobbled up and they gobble up yours, more than anything else the disaster area of the chelation, autism and all the other raft of crap health boards is a testimony to low thyroid and the consequent low brain blood flow, viral impress and low neuron myelination


you have to go quantum to get on a road out




-------------------


 

YAHOO IODINE MESSAGE BOARD POSTS



the amount of iodine recommend by the owner of this message board (50mg daily in four iodoral tablets) is 1/1000th of the lethal dose which may sound like a big dilution, but in fact is too close for regular daily dosing.


1 in 10,000 feels like a minimum dilution to me and practically the 1 mg a day i absorb through my topical iodine tincture protocol is 1 in 50,000


too little iodine and you get cretinism and dull intelligence, too much and you have a general malaise from chronic low level poisoning, both of which are in ample evidence in the posters of this board


this high iodine dose promoting message board is controlled by the chelation borg, has banned me and is very, very, very stupid


please be aware that most of the women on the board who are taking high doses of iodine are also taking thryoid medication


for those of them still with functioning thyroids, the thyroid medication may be sparing the thryoids from making thyroid hormone, and hence reducing mutagenic stress on their thyroids


the


yahoo iodine board is in fact dangerous, the owner just does not get that while the high dose iodine protocol she promotes is essential to keep down her own metastasized thryoid cancer, unless you have that condition then the doses she promotes will harm liver and thyroid function for no benefit


that board is just unbelievable, they line up like flies to get flysprayed!


just look at this post (7th august 2010)


“ Hi all, I have just had an MRI of the breasts. I have a csyt in one and a "nodule" in the other. I have been taking iodoral 25mg for more than a year now. I was hoping that I would not have any problems with my breasts. My Dr doesnt want me to increase it. I have cut out flouride, eat healthy etc.. Im scared that the MRI will show i need surgery.. My Mom died of breast cancer.. any advise would be welcome.. I also take 5000 vit D3, and many other supplements and LDN and armour thyroid meds. Kathy”


25mg will be suppressing thyroid function and the supplements will be a mess. what does she expect ?


________________



Re: Too much Iodoral or detox? Hi. I'm not Stephanie but just wanted to share my experience. I was taking 2 then 3 drops of Lugols in water each morning and my goiter, (I already have one), started getting bigger. My FT4 levels also climbed above the range, and I'm not on ANY thyroid meds. Before I began meds a while back, my FT4 was low in the range. I have not taken it for a few months. I have stopped taking Lugals for now because I feel bad and think it is a combination of things. I think I need to address adrenal issues before I do anything else.


___________________



Z. writes (november 2007)


I've been on 50 mg Iodoral for over 4 weeks. After about a month of taking the Iodoral I started to feel some discomfort in my neck. I deed the thyroid ultrasound and doctor found the large solid nodule in my thyroid? Can Iodoral cause the nodule to grow? .... I am hypo and taking 60 mg Of Armour. I had breast cancer in 2005.


___________________



K. (who is vegan ed.) writes in a post titled 'Help w/iodine and Hashimotos'



I have been on 50mgs of iodoral for approximately three weeks. I pretty much jumped right in with the dosage: one tablet the first day, two the second; then right on with the 50mg the third day.


I had my TSH tested last week, along with a host of other hormone levels. I was surprised that my TSH jumped up to over 5 when in May it was 1.97. I have Hashimotos.


I believe I had read some posts that indicated people with Hashimotos should be careful with dosing iodoral, but other posts that said 'no problem' with taking iodine. Since I had a goiter, I figured I might as well take the iodine. Could the 50mgs have been too much and is it possible that it is stressing my thyroid and making me more hypo?



my reply:



a possibility is you are getting to much iodine and going hypo because of it, hence the rise in tsh


you can cut tablets right down like 1/20th or so, even down to 1/50th


not exact but you just sort of eye it and get the hang of it


also iodine use by the body is a biochemical chain, you need other minerals etc in place to covert from t4 to t3, place it properly in the thyroid, right through to mito switching in the cells


then there are cell permeability issues


but imo 50mg is way over the top


the trouble with hormone supplementation is the body is continually scaling each hormone in relation to others and its a very dynamic process that taking hormones doesn't match, especially in respect of synthroid and brain blood flow
this is why estrogen supplementation doesn't work


my compendium approach with its fine detail supplementation feeds the natural pathways of the body, its complex but there is no other way to get the body to start to work on that scaling again


unless the thyroid is so damaged or is removed or RAI'ed in which case you need hormones, but even then you have to supplement for further downstream utilisation of iodine




------------------------


 

DAVID DERRY



The "test" of putting iodine on the skin to watch how fast it disappears is not an indicator of anything. The iodine disappearance rate is unrelated to thyroid disease or even iodine content of the body.(1-2) Meticulous research by Nyiri and Jannitti in 1932 showed clearly when iodine is applied to the skin in almost any form, 50% evaporates into the air within 2 hours and between 75 and 80 percent evaporates into the air within 24 hours. (1) A total of 88 percent evaporates within 3 days and it is at this point that the evaporation stops. The remaining 12 percent that is absorbed into the skin has several fates. Only 1-4% of the total iodine applied to the skin is absorbed into the blood stream within the first few hours. The rest of the iodine within the skin (8-11%) is slowly released from the skin into the blood stream.


However Nyiri and Jannitti's findings that "The percentage of iodine penetration through the skin is the same, irrespective of whether the cells have a high or low vitality, or are dead, and irrespective of the direction of penetration" have important implications for iodine functions in the body, skin, pregnancy and fetus and also for the therapeutic use of topical and oral iodine. Iodine would be the only compound of significance during early pregnancy which can pass rapidly through all tissues of the fetus without the aid of any blood vessel or lymphatic transport. It could be that not only does iodine control natural cell death (apoptosis) (5) in the fetus but may also influences stem cell development.


Nyiri and Jannetti also mentioned iodine applied on the skin can be used to shrink swelling of the thyroid gland (goiters). So even small amounts of iodine absorbed through the skin can have good effects on body organs. From my own clinical experience, repeated application of iodine (Lugol's) to the skin appears to cause regeneration of the skin from the bottom up (Quiescent, stable or stem cell) (3) eventually sloughing the old version of the skin off like a snake molting. If there was a pre-cancerous lesion on the old skin, it is replaced with new skin minus the lesion. There does not seem to be any skin lesions which are not helped or cured by this procedure. In some cases I found clinically obvious low thyroid conditions also needed to be treated to be more effective. Minor lacerations and healing of surgical wounds respond well. If skin regeneration is from the bottom, then there is little or no scar formation.


My parents' generation tended to put tincture of iodine onto a fresh wound to prevent infection. This turns out to be helpful but not the best way to use it. Besides it stung badly when applied. It is much more effective (and doesn't hurt) to apply iodine repeatedly after a scab has been formed. The iodine put onto the scab helps to organize total repair of the tissue. It is implied a similar approach could be taken to burns of all depths but at the same time the physiology of burns suggest there is an acute lack of thyroid hormone.


All pre-malignant lesions and many other oddities of the skin appear to respond to this regeneration process triggered by topical iodine. I have mentioned previously a patient with a biopsy-proven breast cancer lesion (she refused surgery because of previous cancer treatment) that was strongly fixed to the skin responding well to topical iodine and ended up being a dimple on the breast three year later.


It is my belief a water solution of iodine (like Lugol's) is an important therapeutic agent for skin. Because of its effectiveness and the results, perhaps many skin diseases are related to local tissue areas of relative iodine deficiency. Perhaps the most graphic lesions are the "keloid" (worm) incision scars formed after surgical procedures. If the iodine intake and tissue levels are adequate, such as in Japan, keloid formation doesn't happen (7). In addition, iodine's ability to trigger natural cell death (apoptosis) (5) makes it effective against all pre-cancerous skin lesions and likely many cancerous lesions. The local site is replaced with normal skin. However, even lesser doses of topical iodine seem to reverse the ominous appearance of skin lesions. Because my older brother died of metastatic melanoma, my chances of getting a malignant melanoma are increased by 400 times. (8-9) Having grown up in Venezuela near the equator my sun exposure at a young age was far above normal. So all suspicious lesions I notice are returned to normal with topical Lugol's.


One of the most famous of documentations of iodine skin therapy to a famous person occurred in the American Civil War.


"On September 29, 1862, Colonel John B. Gordon held the center of General Lee's army at the battle of Antietam, or Sharpsburg. The first volley from the northern lines sent a ball through the calf of Gordon's right leg; soon after, another went through the muscles of his thigh; a third pierced his left arm, tearing asunder the tendons and mangling the flesh; a forth ripped through his shoulder leaving a wad of clothing embedded in its track. Still, no bones were broken; but, while Gordon lingered in the firing line, "with", as he says himself, "but little of my usual strength", a fifth ball struck him squarely in the face.


Dr. Weatherly of the 6th Alabama Regiment, in charge of medical arrangements, had the Colonel removed to a base hospital, and prescribed tincture of iodine to be painted on the wounds three or four times a day. The case was unpromising. Gordon's eyelids were greatly swollen; one eye was completely closed, the other almost so; his jaw was immovably clenched, and, to make matters worse, erysipelas (staphylococcus infection of skin) had set in on the left arm.


Mrs. Gordon, his wife, who nursed him - her name was Fanny, and she was then a beautiful girl of 25 - put a liberal interpretation on her instructions and painted the wounds, not three or four times a day, but, as Gordon himself says: "I think three to four hundred time a day." Fanny's diligence and devotion were rewarded. Her husband survived, outlived the war, became the Governor of Georgia, a General, and Commander-in-Chief of the United Confederate Veterans. He died in 1904."


I think Fanny knew iodine applied often was a more effective way to deliver iodine to the body especially applied on multiple sites. Likely Gordon's iodine blood levels and tissue levels rose throughout his body. As iodine is by far the best antibiotic, antiviral and antiseptic of all time, the colonel's body defenses were able to gain control of the infections. At the same time local repeated application to the wound sites caused the skin to grow up from its bottom where all the cells (Stem cells) that make normal skin are residing. Likely this minimized or eliminated scar formation. Thus Nyiri's and Jannetti's studies confirm why Fanny's method of treatment worked so brilliantly. Some of our recent serious skin diseases such a "flesh-eating disease" should respond quickly to topical iodine treatment practiced by Fanny. Or, for another example, iodine put onto a mosquito bite would kill all bacteria and viruses at the site of the bite within 10-30 seconds making it impossible for any virus or bacteria to multiply and get started --such as in West Nile Fever. Naturally, this applies to tic bites (Lyme's disease) as well. For many decades in the 1800s people carried around little bottles of iodine around their necks to use on all occasions. People in mosquito and tic infested areas should think of doing this again. (8) In addition, it has been forgotten vaporized iodine rapidly kills air borne viruses such as polio and SARS viruses.. Used extensively in the forties and fifties it may be of use to explore this approach again.


There has been no significant clinical research on iodine therapy or use for 40 years. (11-15) I feel it is important for research to be directed at this potentially significant area of medical treatment. It is worth noting the greatest part of significant research with iodine was done before the Medline search facilities were available. Of course, since large doses of iodine are tolerated intravenously without side effects, it has yet to be explored what help this may have for many cancer patients or even other diseases.


-----------


an extract from "Breast Cancer and Iodine" by David M. Derry MD, PhD


Iodine and Food Allergies


The Brazillian group found large foreign proteins were made non allergic by reactions with iodine.That seems to explain an old observation seen in the study of iodine in the thoracic duct of dogs.. It was found that concentrations of iodine in the thoracic duct, which is draining the stomach and intestines, is about five times the level in the serum. But if milk was fed to the dogs the thoracic duct iodine content went up 20-30 times. This implies that iodine does in fact coat the foreign proteins like milk and allows them to enter the circulation protected from the immune system attack on a foreign protein."




----------------------


 

TRIALING IODINE



an effective way to trial iodine is buy some povidine iodine cream from the pharmacy (its a very effective antiseptic cream used as a general antiseptic and in surgery)


read the label and cautions


if you decide to proceed, put a small amount on (between a set of toes?) and it should give you a bit of a fillip from the iodine from about an hour? later


if you overdo the povidine iodine it wears off after a day or so and remember the amount absorbed is proportional to the surface area covered so you want to be careful with the amount, just try between a set of toes to start


if it makes you too hyper then you may have issues with heavy metals/autoimmunity or nodules


the iodine is basically the brown colour in the cream


human thyroid hormone is bascially iodine with the tyrosine (an amino acid)


this is just a simple experiment to see the effect of iodine, i do NOT recommend using povidine iodine as a source of supplementary iodine




----------------------



 

FREQUENT DOSING OF POVIDINE IODINE DISPLACES RADIOACTIVE IODINE FROM THE THYROID



http://www.jstage.jst.go.jp/article/expanim/46/3/197/_pdf


(on my computer files as minerals - iodine - thyroid - pi displaces radioactive iodine.pdf)


amazingly effective if you look at the graph in figure 1


it may not be a special effect of pi though, they don't compare with other forms of iodine


iodine tincture with its slow skin release may work as well


a sufficient amount is needed


the super large single doses given by public health authorites for radiation exposure like chernobyl are not the way to do it





----------------------



 

DOES IODIDE IN THE GASTRIC MUCOSA HAVE AN ANCIENT ANTIOXIDANT ROLE?



by Sebastiano Venturi and Marta Venturi, Pennabilli, Italy


The thyroid is derived both embryogenetically and phylogenetically from the primitive gut. As such, we may consider thyroid cells to be primitive gastroenteric cells that during evolution migrated and specialized in iodide uptake, storage, and elaboration of iodinated compounds. The stomach and thyroid share an iodine concentrating ability and many morphological and functional features, such as apical microvilli, secretion of glycoproteins (thyroglobulin and mucin) and amino-acid hormones, the ability to digest and reabsorb, and the ability to form iodotyrosines by peroxidase activity . However, the gastric iodide pump is phylogenetically more primitive than that of the thyroid, has a lower affinity for iodide, and does not respond to TSH.


What is the role of iodide in stomach pathophysiology? Iodide reduces H2O2 in normal thyroid hormonogenesis and defends cells from lipid peroxidation in rats . In previous work we have reported that iodine deficiency or excess might constitute a risk factor for stomach cancer and atrophic gastritis, both by regulating gastric response and by antagonizing the action of inhibitors such as nitrates, thiocyanates, and salt, well known risk factors for gastric carcinogenesis. Recently we have hypothesized that iodide might have an antioxidant role in more ancient organs, particularly in the stomach. In fact, three billion years ago, iodine-rich algae were the first living cells to produce oxygen, which was toxic at that time, in the terrestrial atmosphere. Therefore, algae cells required a protective antioxidant action, in which iodides might have a specific role.


The thyroid gland is phylogenetically a modern organ. It first appeared in a primitive chordate and evolved more recently in mammals. T3 nuclear receptors are evolutionarily recent in comparison with those for T4. In fact, T4 is present in fibrous exoskeletal tissues of invertebrates without any hormonal action. When primitive marine animals started to emerge from the iodine-rich sea and transferred to the iodine-deficient land, their terrestrial diet became iodine deficient and also harbored iodine competitors, such as nitrates, nitrites, thiocyanates and some glycosides. From these considerations, we suggest that these animals learned to use T4 to transport antioxidant iodide into the cells, utilizing the remaining T3 for metamorphosis and thermogenesis, with new hormonal action made possible by the formation of modern T3 receptors.



-----------------



Effect of iodide on total antioxidant status of human serum.Winkler R, Griebenow S, Wonisch W. Paracelsus Gesellschaft of Balneology and Iodine Research, Austria. Free radicals and subsequent lipid peroxidation have been implicated in the pathogenesis of several degenerative and chronic diseases which are also treated frequently in spas. There are some data arising from previous studies which support an antioxidant or scavenging effect of iodide, being the essential ingredient of a therapeutically used local brine. The aim of the study was to test the antioxidant capacity of iodide in human serum. For this reason we measured the so-called Total Antioxidant Status determined by a colorimetric method, which reflects the protection against the attack of reactive oxygen species, including enzymic and non-enzymic antioxidants. Exogenous iodide applied as NaI, shows a significantly increased antioxidant capacity in comparison with NaCl at a concentration of 15 microM, which is quite comparable to the upper range of serum iodide levels achieved through balneo-therapeutical intervention. This result is in accordance with previous results from in vitro depolymerization experiments with hyaluronic acid. The antioxidant effect of 15 microM NaI has been found to be approaching the physiologically relevant concentration of ascorbic acid (50 microM). Copyright 2000 John Wiley & Sons, Ltd.




-------------------



 

HUMAN GENOME SHAPED AROUND IODINE



there's some ability to use iodine beyond the thyroid that may be deeply imprinted in our genes from our evolutionary past


lanceletes (a phytoplankton, filter feeding, sand burrowing, worm-like marine creature) shared a common ancestor with humans 550 million years ago


phytoplankton can be heavily loaded with iodine


“The newly sequenced genome of a dainty, quill-like sea creature called a lancelet provides the best evidence yet that vertebrates evolved over the past 550 million years through a four-fold duplication of the genes of more primitive ancestors.”  study


interestingly, all humans have unusually similar genes


“While two humans typically differ at only one nucleic acid per thousand in the genome, two Lancelets differ at one of every 16 nucleic acids. Marine invertebrates actually vary about 6 percent, which means that, on average, one of every 16 bases is different, which is pretty remarkable - it's the difference between humans and certain types of apes," Putnam said. "Humans really are a special case, because of the recent out-of-Africa bottleneck and because of the size of our population. There is a lot less variation than in these little wormy guys that live by the millions in shallow water.”


___________



The Sea Urchin Genome Sequencing Project (SUGSP) Consortium, led by the Human Genome Sequencing Center at Baylor College of Medicine (BCM-HGSC) in Houston, announced today (November 9, 2006) the decoding and analysis of the genome sequence of the sea urchin, Strongylocentrotus purpuratus.


Sea urchins are echinoderms (Greek for spiny skin), marine animals that originated over 540 million years ago and include starfish, brittle stars, sea lilies, and sea cucumbers. Following the great extinction of animals 250 million years ago, the modern sea urchins emerged as dominant echinoderm species. The purple sea urchin emerged in the North Pacific Ocean during a rapid burst of speciation and diversification 15-20 million years ago.


There was great interest in the sea urchin as a target for genome sequencing because these animals share a common ancestor with humans. That ancestor lived over 540 million years ago and gave rise to the Deuterostomes, the super phylum of animals that includes phyla such as echinoderms and chordates, the phylum to which humans and other vertebrates belong.


All Deuterostomes are more closely related to each other than they are to any other animals not included in the Deuterostome super phylum. For example, among sequenced genomes, the genomes of fruit flies and worms are more distant from the sea urchin genome than is the human genome.


"This analysis shows that sea urchins share substantially more genes and biological pathways with humans than previously suspected," said Francis Collins, director of the National Human Genome Research Institute at the National Institutes of Health, which supported the research. "Comparing the genome of the sea urchin with that of the human and other model organisms will provide scientists with novel insights into the structure and function of our own genome."


To discover how sea urchins and humans can be so different, yet be related by descent from an ancient relative, their genomes were compared. The sea urchin is an invertebrate and the first example of a Deuterostome genome outside the chordates.


The sea urchin fills a large evolutionary gap in sequenced genomes," said Weinstock. "It allows us to see what went on in evolution after the split between the ancestors that gave rise to humans and insects. The sea urchin genome provided plenty of unexpected rewards and was a great choice for sequencing."


Comparing the genes of the sea urchin to the human gene list shows which human genes are likely to be recent innovations in human evolution and which are ancient. It also shows which human genes have changed slowly in the lineage from the ancestral Deuterostome animal and which are evolving rapidly in response to natural selection.


This information, scientists say, will make it possible one day to know the history of every human gene - and build a picture of what the extinct ancestors that gave rise to animal life from worms to humans looked like.


"More than 30 years ago Roy Britten and Eric Davidson offered a comprehensive theory of gene regulation in higher organisms and the sea urchin has been the premier model for testing these predictions" said Richard Gibbs, Director of the BCM-HGSC. "The complete sequence is now available to further these studies."


Because of its evolutionary position, the sea urchin genome sequence was unknown biological territory, said scientists affiliated with the SUGSP.


Some of their discoveries are:


The sea urchin had most of the same gene families found in humans, the Deuterostome toolkit used to create animals in this super phylum. However the size of gene families was often larger in humans, reflecting in part two whole genome duplication events during vertebrate evolution, after the separation of the sea urchin and human evolutionary lines.


One unexpected exception to this size rule was the immune system. Humans have innate and acquired immunity systems. The sea urchin has some of the genes of the acquired immunity system, but its innate immunity branch is greatly expanded with 10 to 20 times as many genes as in humans. Innate immunity is the set of proteins that are "hard-wired" to detect unique molecules of bacteria, such as their cell walls, and signal alert the body to the intruders.


The sea urchin has genes for sensory proteins that are involved in vision and hearing in man. Yet the sea urchin has no eyes or ears, at least as we know them. Some of the visual sensory proteins are located to an appendage known as the tube foot, and likely function in sensory processes there. It is remarkable that the same sensory proteins are used in organs with such different structures in sea urchins and man, said Sodergren.


"The sea urchin reminds us of the underlying unity of all life on earth," she said. "It is a similar set of genes and proteins being reused in different ways, different numbers, and at different times in the life cycle to create the diversity of living forms."




-------------------



 

AGING, DAMAGED DNA ACCUMULATION, GROWTH HORMONE DEPRESSION



http://www.sciencedaily.com/releases/2006/12/061221075222.htm


Jan Hoeijmakers, Ph.D., head of the department of genetics at the Erasmus Medical Center in Rotterdam, Netherlands.


Laura Niedernhofer, M.D., Ph.D., assistant professor of molecular genetics and biochemistry, University of Pittsburgh School of Medicine, and first author of the study.


"The study found that a key similarity between the progeria-like, or progeroid, mice and naturally old mice is the suppression of genes that control metabolic pathways promoting growth, including those controlled by growth hormone. How growth hormone pathways are suppressed is not known, but this response appears to have evolved to protect against stress caused by DNA damage or the wear-and-tear of normal living. The authors speculate that this stress response allows each of us to live as long and as healthy a life as possible despite the accumulation of genetic damage as we age."


without iodine this is what the supplements do, just drive you into this corner, promoting growth hormones on a defective genetic base


i am hoping the iodine and selenium give enough constructive cell turnover so defective genetic material is replaced to escape this corner




----------------------



 

WORK IN PROGRESS



Zhao SJ, Sun FJ, Tian EJ, Chen ZP.
Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China.


OBJECTIVE: To observe the effects of iodine on the level of CD4/CD8 cells and the production of thyroglobulin autoantibody (TGAb) and thyroid peroxidase autoantibody (TPOAb) in Wistar rats and to investigate the role of iodine in thyroid autoimmunity. METHODS: Rat models with different iodine intakes including low iodine (LI,), normal iodine (NI,), 5 times normal iodine (5HI), 10 times normal iodine (10HI), 50 times normal iodine (50HI) and 100 times normal iodine (100HI) were established. The amount of iodine intake per rat per day in every group was about < 1, 6.15, 30.75, 61.50, 307.50, 615.00 microg separately. The levels of CD4 and CD8 immune cells in peripheral blood were measured by using flow cytometry. Radioimmunoassay (RIA) was used to determine the titers of TGAb and TPOAb in the serum. RESULTS: In peripheral blood, the level of CD4 cells in LI group was (57.9 +/- 4.3)%, being much higher than in NI group (51.2 +/- 4.9)%. When the level of CD8 cells in 100HI group was (18.4 +/- 3.1)% showing significantly lower than in NI group (26.5 +/- 4.1)%, thus making the ratio of CD4/CD8 cells in the above two groups (LI: 2.4 +/- 0.40 and 100 HI: 2.7 +/- 0.4) higher than in NI group (1.9 +/- 0.3). As comparing with NI group (2099 +/- 220) CPM, the level of TGAb in LI group (1510 +/- 221) CPM was significantly decreased; while in 50HI group (3986 +/- 286) and 100HI group (3550 +/- 378) CPM, the levels of TGAb were both increased, and the levels of TPOAb in 10HI group (2066 +/- 184) CPM and in 50HI group (2141 +/- 163) CPM were both distinctly lower than in NI group (2372 +/- 245) CPM. CONCLUSIONS: Iodine might exert influence on the level of CD4/CD8, and thus the production of thyroid antibodies might directly or indirectly take part in the process of thyroid autoimmunity. Both low iodine and 100 times normal iodine intakes might activate the immune state on some degrees. The effects of iodine on immune responses of TG and TPO antigen in thyroid autoimmunity might not be completely the same.



----------------



from these studies, the thyroid gets damaged by low iodine


Effect of chronic mild and moderate iodine excess on thyroid anti-oxidative ability of iodine deficiency and non-iodine deficiency Wistar rats][Article in Chinese] Zhang N, Tong YJ, Shan ZY, Teng WP. Department of Endocrinology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.


OBJECTIVE: To investigate the effects of chronic mild and moderate iodine excess on thyroid oxidative injury and anti-oxidative ability of iodine deficiency and non-iodine deficiency Wistar rats. METHODS: Four-week-old Wistar rats were fed with iodine deficient diet for three months to make iodine deficient goiter models, then divided randomly into three groups: iodine deficient control group (Group IDC) fed with double distilled water, iodine-supplement group I (Group IS I) fed with potassium iodate solutions with the iodine concentrations of 100 microg/L, and iodine-supplement group II (Group IS II), fed with potassium iodate solution with the iodine concentrations of 330 microg/L. Another four-week-old Wistar rats were fed with normal diet for three months, and then divided randomly into three groups: normal control group (NC) fed with double distilled water, iodine-excess group I (IEI) fed with potassium iodate solution with the iodine concentration of 300 microg/L, and iodine-excess group II (Group IEII), fed with potassium iodate solution with the iodine concentration of 660 microg/L. 1, 2, 4, 8, and 24 weeks after treatment samples of urine were collected to detect the median urine iodine (MUI), samples of plasma were collected from the hearts of 8-14 rats from each group and then rats were killed. Their thyroid glands were taken out to measure the wet weight and made into homogenate. Biochemical method was used to measure the activities of glutathione-peroxidase (GSH-P(X)) and superoxide dismutase (SOD) as well as the contents of malonyldialdehyde (MDA) and H2O2 in the homogenates of thyroid glands. RESULTS: The GSH-P(X) activity 2 weeks after treatment of Group IS II was significantly lower than that of Group IDC (P < 0.05), and the GSH-P(X) activity 4 weeks after treatment of Group IS I was significantly lower than that of Group IDC (P < 0.001). The activities of GSH-P(X) 4, 8, and 24 weeks after treatment of Groups IS I and IS II were all lower than those of Group C at the same time points significantly (P < 0.001, < 0.01, and < 0.05 respectively). The activities of SOD were decreased gradually in Groups IS I and IS II and were significantly lower than those of Group IDC since 8 weeks after treatment (P < 0.001 or < 0.05). The SOD activities in thyroid glands of Groups IEI and IEII since 8 weeks after treatment decreased significantly in comparison with Group NC (all P < 0.01 or < 0.001). The contents of H2O2 in thyroid glands of Groups IS I and IS II were significantly lower than those of Group IDC at different time points (P < 0.001, < 0.01, or < 0.05), and were significantly lower than those of Group NC 8 and 24 weeks after treatment (P < 0.001 or < 0.01). The contents of MDA in thyroid glands since 2 weeks after treatment of Group IEI were all significantly lower than those of Group IDC at the same time points (all P < 0.05), and the content of MDA in thyroid glands since 1 week after treatment of Groups IS II were all significantly lower than those of Group IDC at the same time points (all P < 0.05). CONCLUSION: Supplementation of 100 microg/L and 330 microg/L iodine on iodine deficiency Wistar rats may alleviate the oxidative injury but weaken the anti-oxidative protection of thyroid. The anti-oxidative protection of thyroid glands of non-iodine deficiency Wistar rats may also be weakened by supplementation of 300 microg/L and 660 microg/L iodine.


PMID: 16796889 [PubMed - in process]


[A study on membrane fluidity of thyroid gland in rats with iodine deficiency or iodine excess][Article in Chinese] Yan Y, Fang H, Xiang J. Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China.


OBJECTIVES: To explore the effect of iodine deficiency and excess on thyroid membrane fluidity and its pathogenesis. METHODS: Wistar rats were fed different levels of iodine in the diet (normal iodine as control, low iodine and excess iodine). Serum T4 and T3 levels, thyroid superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) content were determined, and two parameters of polarization (Pr) and micro-viscosity (eta) using DPH as a florescence probe were tested. RESULTS: Serum T4 and T3 levels in the low iodine (LI) group were markedly decreased, and the thyroid SOD and GPx activities and MDA content were significantly increased compared with the other two groups. However no changes were found in the high iodine (HI) group. There were no differences in Pr and eta values among three groups at 12th week of experiment, but at 24th week, both Pr and eta values in LI group were increased significantly compared to the other two groups. But the effect of iodine excess as expected was not found in this study. CONCLUSIONS: Long-term iodine deficiency caused a marked increase of membrane micro-viscosity and decrease of membrane fluidity in rat thyroid gland. Oxidative damage of thyroid by free radicals and retardation of lipid metabolism are considered as two important pathogenesis factors.


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Andrew (09:12 PM)
: bascially with skin appilcation we drifted into low iodine
Andrew (09:13 PM) : and actually iodised salt may well be a surprsingly effective source of iodine
Andrew (09:13 PM) : but i don't think we are getting anywhere near high iodine
Andrew (09:14 PM) : excpet lugo;s without lithoium on an empty stomach with its very steep absorption rate of the iodine may simulate high iodine for several hours
ollie (09:14 PM) : yeah i think we did, yeah the salts seem to bring a lot to third world countries compared to nothing at all
ollie (09:14 PM) : yeah not so far it seems
Andrew (09:14 PM) : well salt iodine is also oral and eaten with a meal so the absorbtion is buffered
the main issue is buffering the oral idoine to slow the asorbtion rate inot the thyroid

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"We conclude that the abnormal distribution of B lymphocytes, memory and naive T cell subsets in the peripheral blood in children and adolescents with untreated Graves' disease suggests their role in the development of autoimmunity. "


Andrew (09:20 PM) : yeah but could be shrotages of selenium, managanese, zinc magensium and poor folate
Andrew (09:21 PM) : iodine has a cluster of cofacors needed to process it



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"iodine is an easily oxidisable substance. Food that is present in the digestive tract, will oxidize iodine to iodide which is not corrosive to the gastrointestinal tract,Reynolds, 1989; Gosselin et al., 1984)."


ollie (11:03 PM) : so perhaps on a not quite empty stomach would be better, altho amounts we use isnt a lot
ollie (11:04 PM) : When taken by mouth iodine is rapidly converted to iodide and is stored in the thyroid as thyroglobulin, (Reynolds, 1989). Iodine reaches the blood stream mainly in form of iodide, and it is incorporated into the thyroglobulin form in the thyroid gland, (Jones, 1977).


Andrew (11:05 PM) : the lugols is alrady about 60% iodide
ollie (11:05 PM) : Toxicodynamics Local Iodine precipitates proteins. The affected cells may be killed. The effect is similar to that of a corrosive acid.


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Potassium Iodate and Its Comparison to Potassium Iodide As a Blocker of 131I Uptake by the Thyroid in Rats.


Health Physics. 65(5):545-549, November 1993. Pahuja, D. N.; Rajan, M. G. R.; Borkar, A. V.; Samuel, A. M.


Abstract: Potassium iodide is the preferred thyroid blocker for personnel handling radioiodine and is recommended as a prophylaxis for the population in the near-field of a nuclear reactor which would be likely to be exposed to radioiodine in an accidental breach of containment. However, in hot and humid climates, this hygroscopic chemical has a poor shelf life due to hydrolytic loss of iodine vapors. On the other hand, another iodine-rich salt, potassium iodate (KIO3), is quite stable and has a much longer shelf life. The present study compares potassium iodide and KIO3 as thyroid blockers and examines the appropriate time at which they should be administered in case of radioiodine exposure. Either of the two were given in recommended dosage (100 mg stable iodine per 70 kg body weight) at -2, 0, +2, +4, +6, and +8 h after administration of tracer quantities of radioiodine (131I) to age-, weight-, and sex-matched rats. 131I uptake in thyroid was measured 24 h after its administration in the experimental animals and compared with placebo administered controls. Results suggest that KIO3is as effective a thyroid blocking agent as potassium iodide. In comparison to controls, 24-h thyroid uptake of 131I can be substantially reduced if potassium iodide or KIO3 is given to the animals within 2-4 h after exposure to 131I. Another noteworthy observation is that KIO3 is effective even at 8 h when administered at twice the usual dosage in comparison to the single dose, which does not show appreciable thyroid blocking properties after 8 h.


The Toxicology of Iodate: A Review of the Literature May 2001, Vol. 11, No. 5 : 449 -456 H. Bürgi, Th. Schaffner, J.P. Seiler


In humans and rats, oral bioavailability of iodine from iodate is virtually equivalent to that from iodide. When given intravenously to rats, or when added to whole blood or tissue homogenates in vitro or to foodstuff, iodate is quantitatively reduced to iodide by nonenzymatic reactions, and thus becomes available to the body as iodide. Therefore, except perhaps for the gastrointestinal mucosa, exposure of tissues to iodate might be minimal. At much higher doses given intravenously (i.e., above 10 mg/kg), iodate is highly toxic to the retina. Ocular toxicity in humans has occurred only after exposure to doses of 600 to 1200 mg per individual.









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