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From: Microscopic killer baffles scientists
Date: 05 May 1999
Time: 00:15:08
In a quarantined laboratory, U.S. scientists outfitted in plastic biohazard spacesuits and breathing through air tubes are probing a killer that has struck on the other side of the world. The mysterious microscopic enemy has killed more than 100 people in Malaysia in seven months, and scientists are baffled about its origin and mode of transmission.
``Every couple of years something like this comes along,'' said Dr. C.J. Peters, head of the special pathogens branch at the Centers for Disease Control and Prevention. ``We don't know how this stuff spreads, how far it's going to go. We really don't know what's at the end of the tunnel.''
The rare form of viral encephalitis, which spread from pigs to humans, first surfaced last year near the northern city of Ipoh. It has since sickened more than 250 Malaysians, mostly pig farmers. Many of their herds also fell ill, and some pigs died. A similar illness afflicted 11 slaughterhouse workers in Singapore, one fatally, who butchered pigs imported from Malaysia.
Soldiers have killed almost 1 million pigs and some stray dogs to try to curb the virus. On Monday, pet owners in Malaysia's high-risk areas were told to get their animals checked immediately after new tests confirmed house pets could transmit the disease to humans.
Medical authorities named the new virus Nipah, after the village where it was first isolated.
As remote as the Nipah virus may seem, controlling and understanding it are a concern of epidemiologists around the globe because of fear it could spread quickly.
For months, Malaysian health officials were certain the killer was Japanese encephalitis, a mosquito-borne virus common to the area. The two pathogens cause similar symptoms -- high fever, aches, eventual coma and often death.
But most people in the region had been vaccinated for Japanese encephalitis as children. Additionally, it doesn't usually kill adult pigs.
The government declared a state of emergency in three Malaysian states and launched fogging and vaccination campaigns, to no avail. The Nipah virus raged on. And despite no proof that Nipah can infect people who eat or handle pork, the epidemic has wreaked havoc on Malaysia's nearly $400 million pork industry.
On March 7, baffled Malaysian researchers sought help from their counterparts at the CDC office in Fort Collins.
The samples were taken to the CDC's Level 4 biocontainment lab, which houses deadly microbes that have no vaccine or cure, such as the Ebola virus that killed 245 Zaireans in 1995.
The CDC's medical detectives quickly identified the culprit as related to but far deadlier than the very rare Hendra virus. Hendra was first detected in 1994 in Australia, where it killed 15 racehorses and two trainers.
But they know little else.
``That indicated right away that this was something big. We knew it was a new virus, and we knew it was related to a virus that kills people,'' Peters said. ``We're not talking about an outbreak of colds that's going to run through and everybody's going to get over it.''