LOWRY remained at San Pedro Bay until 19 August 1945, undergoing repairs and conducting underway training exercises with other units of Destroyer Squadron 60. On 20 August she sailed for the Tokyo area where she joined a carrier task group under command of Rear Admiral A.W. Radford in YORKTOWN. She operated to the south and east of Honshu, Japan in support of the allied landings for occupation and furnished food for allied prisoners of war. On 16 September 1945, LOWRY entered Tokyo Bay, departing 1 October to pick up passengers from Okinawa and the Marianas Islands for return to the United States. She departed Okinawa 9 October and arrived San Diego, 21 October 1945.

LOWRY remained at San Diego for the Navy Day Celebrations and more than 10,000 visitors were escorted through the ship. On 29 October 1945, she entered Terminal Island Naval Shipyard of San Pedro and underwent overhaul until 24 January 1945. After refresher training in local areas from ports of California she departed San Francisco 14 July 1946, enroute via Pearl Harbor to the Marshall Islands.

On 24 July 1946, LOWRY arrived Kwajelein Atoll to act as a surface patrol vessel during "Operation Crossroads" in connection with the Bikini atomic bomb tests. She departed Bikini 10 August 1946 and returned to San Diego on 22 August. She maintained a schedule of training exercises in local areas of San Diego until 6 January 1947 then sailed for Fleet maneuvers in the Hawaiian area. On 17 February she departed Pearl Harbor for a training cruise to the Marshall Islands, returning 11 March to continue maneuvers in the Hawaiian area.

On 5 April 1947 Commander Edwin S. Miller was relieved by Commander Bernard F. Foeder, U.S.N. On 1 May she sailed with Carrier Divsion THREE, (U.S.S. SHANGRI-LA (CV-38) and U.S.S. ANTIETAM (CV-36)); Cruiser Division FIFTEEN, (U.S.S. DULUTH (CL-87) and U.S.S. ATLANTA (CL-104)) and other elements of Destroyer Squadron SEVEN; U.S.S. O'BRIEN (DD-725), U.S.S. MOALE (DD-693), U.S.S. WALKE (DD-723), U.S.S. LAFFEY (DD-724), U.S.S. INGRAHAM (DD-694), U.S.S. ALLEN M. SUMNER (DD-692) and U.S.S. ROBERT K. HUNTINGTON (DD-781) enroute to Sidney, Australia for a Goodwill Visit (17-27 May). During this transit the entire Task Force THIRTY-EIGHT crossed the International Dateline (180th Meridan) and the Equator simultaneously. All polywogs were properly initiated into the Ancient Order of the Deep as "Shellbacks" and also into the Society of the Flying Dragon.

On 14 June the LOWRY returned to San Diego for inactivation. Commander Foeder was succeeded by Lieutenant Commander Hollis C. Rowls, U.S.N., on 27 June 1947. LOWRY was placed out of commission in reserve on 30 June 1947.

LOWRY was recommissioned at San Diego on 27 December 1950. Upon commissioning, her executive officer, Lieutenant Commander Arthur C. Jackson, U.S.N., acted as Commanding Officer until 29 December, when Commander Charles H. Morrison, U.S.N., reported as Commanding Officer. She conducted shakedown training out of San Diego until 9 April 1951 then departed to escort carrier HORNET (CV-12) to New York City. She arrived at New York 30 April 1951 and was asigned to Destroyer Division 261, Squadron 26 of the Second Flotilla, U.S, Atlantic Fleet.

On 3 May 1951, LOWRY arrived at Norfolk for overhaul and post repair trials until 22 August 1951 when she sailed for Atlantic Fleet exercises in the Caribbean Sea while based at Guantanamo Bay, Cuba. LOWRY returned to Norfolk 15 November and conducted local operations until 22 January 1952. Commander Charles H. Morrison, U.S.N. was relieved by Commander Charles B. Carroll, U.S.N., on 2 January 1952. On 22 January LOWRY sailed to join units of the Seventh Fleet in support of the Korean War. Steaming via the Panama Canal, San Diego, Pearl Harbor and Midway, she arrived at Yokosuka, Japan on 27 February 1952.

LOWRY joined Carrier Task Force 77 off the east coast of Korea on 5 March 1952. The next day she was detached with cruiser U.S.S. ST. PAUL (CA-73) and after a gunstrike mission which included shore bombardment on targets to the south of Songjin, North Korea, rejoined the Task Force on 7 March 1952. Her duties as plane guard and screening unit for the carriers were again intervened 13-15 March when she joined ST. PAUL for bombardment of railway targets to the south of Songjin, repeating an identical mission with cruiser U.S.S. ROCHESTER (CA-124) on 25-26 March. On 30 March she rescued a pilot who crashed upon take-off from carrier U.S.S. PHILLIPPINE SEA (CV-47). She then steamed to conduct anti-submarine warfare exercises off Okinawa and continued to participate in hunter-killer operations while enroute from that island to Yokosuka, Japan, arriving 12 April 1952. After replenishment at Sasebo she departed 28 April for the West Coast of Korea. On 29 April she joined British carrier HMS GLORY and became a unit of Task Element 95.11. The next day she commenced blockade and patrol duty of the inshore Islands of Poongyong-Do and Taechong-Do. She took enemy troop concentrations under bombardment on those islands and continued fire support missions in the area to destroy enemy gun emplacements, targets on the beach and other installations until 28 May 1952. During this duty, 11 May, she rescued a pilot of the Royal Australian Navy. Just after nightfall on 19 May she anchored off the Korean shore and came under fire of three Communist shore batteries. She got underway within 30 seconds and silenced the enemy guns while weighing anchor. On another very hazardous assignment, LOWRY steamed alone up the Yalu River at night to deliver supplies and ammunition to a contingent of Marine Raiders operating behind Communist lines. The Yalu River was the boundary between Red China and North Korea. With the constant threat of danger from both shores, LOWRY successfully navigated in total darkness and with no navigational aids while using the only chart available; a Royal Navy Chart, circa 1854.

LOWRY returned to Yokosuka for replenishment on 30 May and joined Carrier Task Force 77 off the east coast of Korea on 8 June 1952. She conducted gunstrike missions on the east coast of Korea 10-12 June and returned to Yokosuka on 18 June 1952. On 22 June 1952, LOWRY departed Yokosuka with other ships of Destroyer Division 261, enroute to Norfolk via the Suez Canal and principal ports of the Mediterranean. Ports of call included Singapore, Malaya, Colombo, Ceylon, Aden, Arabia; Port Said, Egypt; Istanbul, Turkey; Piraeus, Greece; Naples, Italy; Cannes, France; and Gibraltar. She arrived at Norfolk 19 August 1952, having completed a world cruise since her departure from that port in January.

From 19 August 1952 to 1 February 1954, LOWRY was based at Norfolk. During this time she made two training cruises in the Caribbean Sea which included intensive anti-submarine warfare exercises and gunnery training as well as amphibious operations. She also made a voyage from Norfolk to Pensacola, Florida (17 April-15 May 1953), acting as plane guard for light carrier U.S.S. MONTEREY (CVL-26). These duties were intervened by overhaul in the Philadelphia Naval Shipyard from June to September 1953 and a brief visit to New York City. LOWRY was awarded the Battle Efficiency Award for fiscal year 1953 based on maintaining the highest standards in operational readiness.

Commander Carroll was relieved by Commander James F.B. Johnston, U.S.N., on 27 January 1954. LOWRY departed Norfolk for a second world cruise on 1 February 1954. She transited the Panama Canal and after calling at San Diego, and Pearl Harbor, arrived at Yokosuka, Japan on 9 March 1954. Operating from ports of Japan as a unit of the Seventh Fleet, she participated in Marine Division Landing Exercises which included a simulated full scale invasion of Iwo Jima and performed escort duty and security patrol off Korea. On 29 June 1954, she departed Yokosuka to continue her world cruise via Hong Kong, Singapore, Colombo, Port Said and Gibraltar. She visited Lisbon, Portugal (14-17 August) and returned to Norfolk on 25 August 1954. Here she received her second consecutive Battle Efficiency Award (for fiscal year 1954).