JIHONG WANG
107 Sunnyside Ave., Arlington, MA 02474
781-648-6128(H), 781-306-0808 x7107(O)
URL: http://members.tripod.com/~jh_w/
E-mail: jihong_wang@ustc.edu

EDUCATION:
     Rutgers, The State University of New Jersey, New Brunswick
          Ph.D. in Chemistry, 1997, M.S. in Chemistry, 1996
             * GPA: 3.8/4.0
     University of Science and Technology of China, Hefei, China
          B.S. in Chemistry, 1988

EXPERIENCE:
Senior Scientist,  Jan. 2000 - present 
Scientist,  Jan. 1999 - Dec. 1999 
Consensus Pharmaceuticals, Inc., Medford, Massachusetts. 
   * Lead protein affinity purification and sequencing group.
   * Method development and validation for Protein Kinase Assay, Protease Assay, 
      and Receptor-binding Assay.
   * Peptide library synthesis and purification. 

Postdoctoral fellow, Oct. 97 - Jan. 1999 
Center for Advanced Biotechnology and Medicine (CABM), University of
Medicine and Dentistry of New Jersey, Piscataway, New Jersey.
   * Designed and Synthesis of antisense peptide-DNA conjugates for Breast Cancer treatment.
   * In charge of lab safety issues.

Graduate Assistant, Aug. 92 - Sept. 97
Department of Chemistry, Rutgers University, New Brunswick, New Jersey.
   * Played key role in the AIDS drug research team.
   * Developed a gel shift binding assay for screening small molecules specifically 
      binding to DNA or RNA.
   * Designed, synthesized, and screened series of Tat peptide analogs and
      peptide-oligonuclotide conjugates targeting TAR RNA of HIV-1.
   * Discovered a Tat peptide analog that can inhibit HIV-1 replication.(Patent Pending)
   * Engaged in setting up cell uptake assay, drug stability assay and drug delivery system.
   * Analyzed and interpreted data in terms of pharmacokinetics and pharmacodynamics
      model of drug action and its interaction.
   * Taught undergraduate courses in Experimental Chemistry.

Research Assistant, Sept. 91 - Aug. 92.
National Laboratory of Computer Chemistry, Chinese Academy of Sciences,
Beijing, China.
   * Engaged in Pesticide Database setup and SAR studies.

Research Assistant, Jan. 88 - July 91.
University of Science and Technology of China, Hefei, China.
   * Prepared superconducting thin films by plasma technique and characterized 
      the structure of corundum type oxide and superconducting oxides by IR and 
      X-ray diffraction.
   * Taught undergraduate courses in Physical Chemistry and Crystal Chemistry.

HONORS and AWARD:
   * CABM Fellowship, Rutgers University (1995).
   * People's scholarship, University of Science and Technology of China
     (1985 & 1987).

SKILLS:
Analytical and Bioanalytical Chemistry:
   *  HPLC purification of peptides, oligonucleotides, and small molecules.
   *  RNA, DNA and Protein Gel Electrophoresis.
   *  TLC, Gel Filtration 
   *  Fluorescence and UV-Vis spectrometry,
   *  ELISA, RIA
   *  Protein Sequencing, Amino Acid Analysis.
   *  MALDI-MS, NMR, IR.

Synthesis:
   * Solid-Phase Synthesis of Peptides and Oligonucleotides.
   * Expertise on conjugation reactions, peptide modifications, and PEG chemistry.
   * Familiar with Combinatorial Library Syntheses.

Molecular Biology:
   * Carried out Cloning, Restriction Mapping and Analysis, plasmid isolation, PCR.
   * Performed RNase H Cleavage Assay and Phosphor Image Analysis.
   * Working knowledge of cell culture and cell uptake studies.

Computer:
   * Windows, DOS, VMS-VAX, UNIX.
   * Programmed with FORTRAN, BASIC, HTML, Perl.
   * Expertise in Excel, Word, Photoshop, Insight II, GCG, and
     other applications and database programs.

PUBLICATIONS:
  1. J.H. Lai and J. Wang, "Purification and Analysis of Cyclic Peptide Libraries, and 
      Compositions Thereof". Patent Pending. 
  2. J.H. Lai, J.J. Johnson, L. Josephson, E.K. Kolaczkowski, J. Wang, J.J. Nestor, 
      and S.A. Kates. "Nucleophilic and Conformational Effects of Amino Acids in 
      Head-to-Tail Cyclic Peptide Libraries", Proceedings of the 6th International 
      Symposium on Solid Phase Synthesis and Combinatorial Chemical Libraries, 
      (R. Epton, Ed.) Mayflower Scientific Ltd., Kingswinford, England, in press.
  3. I. Choudhury, J. Wang, S. Stein, A.B. Rabson and M.J. Leibowitz "Translational 
      Effects of Peptide Antagonists of Tat Protein of HIV-1", J Gen Virol, 80(Pt3), 
      777-82 (1999).
  4. J. Wang, S. Stein, M.J. Leibowitz and A.B. Rabson, "Inhibition of HIV-1 Replication
      by a Tat RNA-binding Domain Peptide Analog", patent pending.
  5. S-Y. Huang, S. Pooyan, J. Wang, I. Choudhury, M.J. Leibowitz and S. Stein. 
      "A Polyethylene Glycol Copolymer for Carrying and Releasing Multiple Copies of 
       Cysteine-Containing Peptides", Bioconjugate Chemistry, 9(5) 612-617 (1998).
  6. I. Choudhury, J. Wang, A.B. Rabson, S. Pooyan, M.J. Leibowitz and S. Stein, 
      "Inhibition of HIV-1 Replication by a Tat RNA-binding Domain Peptide Analog", 
       Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 17, 
       104-111 (1998).
  7. C.E. Lau and J. Wang "Alprazolam, Caffeine and Their Interaction: Relating DRL  
      Performance to Pharmacokinetics". Psychopharmacology 126, 115-124 (1996).
  8. J. Wang, S-Y. Huang, I. Choudhury, M.J. Leibowitz and S. Stein. "Use of a 
      Polyethylene Glycol-Peptide Conjugate in a Competition Gel Shift Assay for 
      Screening Potential Antagonists of HIV-1 Tat Protein Binding to TAR RNA", 
      Analytical Biochemistry, 232, 238-242 (1995).
  9. C.H. Tung, J. Wang, M.J. Leibowitz and S. Stein. "Dual-specificity Interaction of 
      HIV-1 TAR RNA with Tat Peptide-oligonucleotide Conjugates", Bioconjugate 
      Chemistry, 6(3) 292-295 (1995).
 10. Y Qian, S Yan, J Wang, P Fu and Z Chen. "An IR Study on Thin Films of Corundum 
      Type Oxides". Chinese Journal of Chemical Physics, 5(4) 275-280 (1992).
 11. Z. Chen, G Zhou, Z Li, J Wang, D Sun and Y Qian. "Structure Characteristics of  
       High Tc Superconducting Oxide in (Bi,Pb)-Sr-Ca-Cu-O system". Molecular Crystals 
       &. liquid Crystals, 184, 401-408 (1990).
 12. W liu, J Wang, Z Yang, Y He, H Zhao, Z Chen and Y Qian. "Preparation of 
       Superconducting Bi-Sr-Ca-Cu-O Thin Films by RF Sputtering". Chinese Journal of 
       Low Temperature Physics, 11(6), 464-469 (1989) (in Chinese).

IMMIGRATION STATUS:
Permanent resident of US.