"For ten thousand years we have fought the Long War and our hatred still knows no succor. Those who have defied us shall feel the full wrath of Chaos... Death To The False Emperor! Death To The Weakling Imperium Of Man!"
10,000 years ago the Emperors most trusted Primarchs, Warmaster Horus, was lead to beleive by the treacherous Chaos gods that he, not the Emperor was meant to rule Humanity. Almost half of the Space Marine factions turned traitor and they plunged into a civil war, the Horus Heresay War.
The rebellion was ended when Horus was killed by the Emperor himself. The remaining traitors, The Chaos, plunged into the Eye of Terror, a tear the very fabric of reality where they still lurk, plotting against the Emperor, the Imperium, and al of Mankind.