Back to Lupron.com The health information contained here is provided for educational purposes only and is not intended to replace discussions with a healthcare provider All decisions regarding patient care must be made with a healthcare provider and consider the unique characteristics of each patient. Side effects with Lupron Depot alone are generally those related to hypoestrogenism, including vasomotor flushes, headaches, and vaginal dryness. After six months of therapy with Lupron Depot 3.75 mg, vertebral bone density decreased by an average of 3.2%, compared with pretreatment value. Partial to complete recovery of bone density was recorded in the posttreatment period. The most commonly reported side effects of Lupron Depot plus norethindrone acetate 5 mg daily were hot flashes, headache, nausea/vomiting, depression/ emotional lability, and asthenia. In addition, Lupron Depot plus norethindrone acetate-treated patients had significantly decreased HDL levels and significantly increased LDL/HDL ratios. After treatment, mean serum lipid levels from patients with follow-up data returned to pretreatment values. Norethindrone acetate should be used with caution in women with cardiovascular risk factors including lipid abnormalities and cigarette smoking. Refer to the norethindrone acetate prescribing information for warnings, precautions, contraindications and adverse reactions. Although the disease more commonly occurs in women in their 20s and 30s, endometriosis can affect women at any time during childbearing years. In fact, it is estimated that endometriosis affects 10% to 20% of premenopausal women in the United States. what is endometriosis? Endometriosis occurs when tissues like those that line the uterus grow outs ide the uterus. The growths associated with endometriosis often occur on the ovaries, fallopian tubes, ligaments supporting the uterus, and other areas in the pelvic cavity. Other possible sites of endometriosis include the bladder, bowel, and vagina; however, endometriosis can appear in other places in the body. In some instances, pelvic scarring and adhesions may occur. These, in turn, may prevent a woman from being able to become pregnant. Like the lining of the uterus, areas of endometriosis respond to the hormones of the menstrual cycle. The endometrial areas build up tissue each month, then break down and bleed during menstruation. However, when endometrial growths outside the uterus bleed, they can irritate the body. why is this a problem? The build-up of scar tissue is thought to be a cause of chronic pelvic pain , a symptom which many women with endometriosis experience. In fact, chronic pelvic pain is associated with endometriosis in 71% to 87% of the cases. However, the amount of pain a woman may experience is not related to the extent of her endometriosis. Some women with moderate to severe endometriosis have no pain, while others with minimal endometriosis experience severe pain. That is one reason why an accurate diagnosis of the disease is so difficult. To date, the exact cause of endometriosis remains unclear, but medical researchers continue to investigate the disease and hope to find a cure.
Most common side effects with Lupron Depot are generally those related to hypoestrogenism, including vasomotor flushes, headaches, and vaginal dryness. A small amount of bone loss (average 3.2%) may also occur during therapy with Lupron Depot alone, but usually is partially or completely recovered after you stop taking Lupron Depot. The most commonly reported side effects of Lupron Depot plus norethindrone acetate 5 mg daily were hot flashes, headache, nausea/vomiting, depression/emotional lability, and asthenia. In addition, Lupron Depot plus norethindrone acetatetreated patients had significantly decreased HDL levels and significantly increased LDL/HDL ratios. After treatment, mean serum lipid levels from patients with follow-up data returned to pretreatment values. Norethindrone acetate should be used with caution in women with cardiovascular risk factors including lipid abnormalities and cigarette smoking. Refer to the norethindrone acetate prescribing information for warnings, precautions, contraindications and adverse reactions. Lupron Depot®3 Month 11.25 mg Lupron Depot® 3.75 mg Here are the facts, plain and simple, about Lupron Depot. Be sure to read myths and facts to help clarify any rumors you might have heard. Then see patient stories to see and hear a real-life Lupron Depot patient and her experience with endometriosis and Lupron Depot. what you should know about lupron depot. 1. Lupron Depot, a GnRH agonist, is effective for the treatment of endometriosis. After completing a maximum of 6 months of therapy, 96% of patients reported no painful periods (dysmenorrhea), 66% reported no pelvic tenderness, and 53% reported no pelvic pain. 2. Treatment with Lupron Depot lasts. Symptom relief can extend well beyond the treatment period for many women. In women who completed the 12-month follow-up after the end of Lupron Depot therapy, 76% of patients previously reporting painful sexual intercourse (dyspareunia) were still symptom-free. Of women who had pelvic tenderness before using Lupron Depot, 61% were symptom-free after a year. Over half the women with pelvic pain were symptom-free a year after Lupron Depot therapy. 3. Lupron Depot therapy can actually shrink the endometriotic implants that have been causing pain in your abdomen. In clinical studies, women with pelvic pain underwent diagnostic laparoscopy before and after they were treated with Lupron Depot for 6 months. In the women in whom surgeons could actually see endometriotic lesions and implants, the surgeons observed that a full course of Lupron Depot therapy had substantially reduced the size of the endometrial implants. 4. Many women with endometriosis experience pain relief within the first 3 months of Lupron Depot therapy. In order to determine whether or not Lupron Depot is going to work for you, your physician may recommend a trial of therapy for 3 months. Many patients can tell within that period of time whether or not Lupron Depot will work to control their pelvic pain. If it is working for you, your physician may have you complete the entire 6-month regimen. Treatment with Lupron Depot for 6 months has shown long-lasting symptom relief. 5. Just 6 months of therapy can mean years of pain relief. While a course of GnRH agonist therapy is for 6 months, many women report pain relief for up to 5 years after they have finished therapy. In fact, in one study, 63% of patients with mild disease reported being symptom-free 5 years after the end of GnRH agonist therapy,* and 26% of patients with severe disease reported being symptom-free. *Drugs used in this study include: Zoladex® (goserelin acetate implant), a registered trademark of Astra Zeneca Pharmaceuticals LP. Synarel® (nafarelin acetate), a registered trademark of Pharmacia Corporation. Suprefact® (buserelin acetate), a registered trademark of Aventis Pharmaceuticals. 6. If symptoms return, you can take a second 6-month course of Lupron Depot If, after completing therapy, your pain returns, your doctor may prescribe Lupron Depot plus norethindrone acetate 5 mg daily for an additional 6 months. The benefits of add-back therapy can be a decrease in the frequency of hot flashes and a significant reduction of bone lossin addition to the pain relief that Lupron Depot provides. 7. Lupron Depot is well tolerated. Lupron Depot, like any of the other drugs in its class that are used for endometriosis, works by putting your body into a temporary state of menopause, so most side effects of Lupron Depot therapy are similar to what women experience during menopause. These can include hot flashes, headaches, no periods, and vaginal dryness. These symptoms are a result of a temporary state of menopause and are generally reversible after the drug is discontinued. Many patients have established ways of tolerating side effects, most notably hot flashes, in much the same way women going through the first stages of menopause have learned to cope with their symptoms. Examples include dressing in layers
If you are concerned about hot flashes tell your doctor. Your doctor may add norethindrone acetate 5 mg daily to your Lupron Depot therapy, which can reduce hot flashes while still maintaining Lupron Depot's efficacy.
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