(Probe, (1984): (XXIII), 2, 82-83)

Role of CYSTONE Tablets in Ureteric Calculi and
Urinary Tract Infections (E. coli)

Dalbir Singh, M.B.,B.S.
Consultant Physician,
Police Hospital, Rohtak (Haryana), India.
Now : Registrar, Dept. of Forensic Medicine, Medical College, Rohtak.

INTRODUCTION

Urolithiasis in developing countries like India is more amongst the population whose diets contain low amount of inferior quality proteins. It is also reported that high intake of animal protein like meat, fish and poultry products might augment the risk of stone formation. Dietary imbalance of minerals, namely calcium, phosphorus and magnesium are common causative factors of urinary calculi disease (Dr. Anasuya Das, National Institute of Nutrition, Hyderabad, Nutrition News (1982) : 5, 1).

Urinary tract infection patients complain of burning micturition, pyrexia etc. Most of the patients were suffering from E. coli infections.

Cystone, a product of The Himalaya Drug Co., Bombay has been extensively evaluated in ureteric calculi and U.T.I. cases with excellent results (Dandia 1975, Gupta 1976, Saronwala 1973, Trivedi 1974, Gohsal 1980).

Cystone is claimed to correct crystalloid-colloid imbalance and relieve the binding mucin of calculi. It acts as a urinary antiseptic, antispasmodic and diuretic. Cystone is known to relax the detrusor muscles and promote diuresis by virtue of its high content of natural mineral salts. The prolonged use of Cystone does not disturb the electrolyte balance. The composition of Cystone is as follows :

COMPOSITION

Each Cystone tablet contains :

Exts: Didymocarpus pedicellata

65 mg

Saxifraga ligulata

49 mg

Rubia cordifolia

16 mg

Cyperus scariosus

16 mg

Achyranthes aspera

16 mg

Onosma bracteatum

16 mg

Vernonia cinerea

16 mg

Shilajeet (Purified)

13 mg

Hajrul yahood bhasma

16 mg

MATERIAL AND METHODS

A clinical trial was undertaken on 10 patients of ureteric calculi with 1.5 cm. calculi treated with Cystone tablets 2 t.i.d. for 3 months.

20 cases of U.T.I., having E.coli infection, were divided into three groups.

Group A : In this group 7 patients were given Cystone 2 t.i.d. for 10 to 12 days or till the infection cleared.

Group B : 7 patients in group B were given Cystone tablets 2 t.i.d. for 10 days and co-trimoxazole 2 b.i.d. for 5 days.

Group C : This group of 6 patients received nitrofurantoin 1 t.i.d. for 10 days with co-trimoxazole 2 b.i.d. for 5 days.

Table I : Cases divided
 

A
Cystone

B
Cystone + co-trimoxazole

C
Co-trimoxazole + nitrofurantoin
Ureteric calculi

10

-

-
U.T.I.

7

7

6

Table II : Age and sex distribution
 

No. of patients
Years

Male

Female

Total
11 - 20

2

-

2
21 - 30

8

-

8
31 - 40

9

2

15
41 - 50

3

6

5
 

22

8

30

Table III : Results
 

A
Cystone

B
Cystone + co-trimoxazole

C
Co-trimoxazole + nitrofurantoin
Ureteric calculi

10

-

-
U.T.I.

6

7

5

RESULTS

All the patients of ureteric calculi passed out calculi with Cystone. Six patients passed out calculi in 30 days and the remaining 4 cases passed out their calculi within 3 months of treatment. Out of 7 patients in Group A (U.T.I.) 6 recovered, i.e. 100% results, whereas in Group C out of 6 patients, 5 patients responded to this combination (see Table III).

DISCUSSION

In this series Cystone proved promising in 10 cases of ureteric calculi and in 20 cases of urinary tract infections. Cystone can be combined with co-trimoxazole or used in pregnancy where co-trimoxazole is contra-indicated. In such cases instead of giving an antibiotic we should recommend Cystone. None of the patients reported any toxic effects with Cystone therapy.