William B. Davis: If there is [any tension between David and Gillian], I haven’t seen it. But then I haven’t seen them together that often. I don’t see a whole lot of Gillian, period, but when I’ve seen them together they seem fine. They come back to work on Monday and say, ‘Where did you go on the weekend?’ Normal stuff.
-Neon

Gillian Anderson: Well, most of the time when we have discussions about the press, it has to do with mending things and saying, "It's not how I feel."
David Duchovny: Like, "When I said you were an asshole, I meant to say motherfucker."
Gillian Anderson: Exactly.
-Us Magazine

David Duchovny: At this point you can't imagine anybody else [but Gillian] playing [the] part [of Scully]. There's not just one thing she does. She's made it her own part. So, there's nobody else to do it. She brings whatever her talents as an actress are.
Q: What about David?
Gillian Anderson: One thing I don't think people realize is a lot of the humor in the character of Mulder is not only heightened by David but a lot of times he will add his own lines. A lot of Mulder's dry sense of humor comes more out of David than anything the writers can conjure up.
-Us Magazine

Gillian Anderson: There have been defining moments over the past four years where we have, not necessarily for career advice, but when we have both been there for each other for support.
Q: Examples? We love examples.
Gillian Anderson: Well, I won't give any.
David Duchovny: When my goldfish died.
Gillian Anderson: But most of the time, we have our own separate support systems and deal with things in our own way.
David Duchovny: I guess the only thing we'd talk about now is when we want to do the X-Files movie. I think we both want to do it as soon as possible so we can get it over with. [Anderson looks genuinely startled.]
Oh. [Pause] I don't know if you do.
Gillian Anderson: Have we talked about it?
David Duchovny: We did a little bit early in the year.
Q:So, who will make the final decision about the movie?
David Duchovny: We're all gambling on Chris right now because he has to come up with a script. Both of us are holding out on other things out of loyalty to him. But it's going to be ugly if we don't do the movie and end up not having anything to do during the hiatus because we waited. It won't be a happy set.
-Us Magazine

Kim Manners: They're totally different human beings, but they can just look at each other and know exactly where they're going in a scene. It's weird. David and Gillian are best of acquaintances; Scully and Mulder are best friends.
-Us Magazine

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