Side-lined for five years since their spectacular save and near destruction of New York City, the superstars of the supernatural spring back into action when the infant son of single-mother Dana Barret becomes the target of a powerful demonic force. Reunited with the no-nonsense Zeddmore, nerdy near-sighted Louis Tully and their ever industrious secratary Janine, the heroes of the herafter must put a stop to an enormous underground river of slime ready to rot the roots of the Big Apple.