Notorious B.I.G. & Puff Daddy - This is all because Biggie and Puffy knew what was happening when Pac got shot in '95 and they acted like they didn't even know who it was that shot him, even though Pac found out who it was while he was in jail and that the person was from Biggies neigborhood. Other reasons like the fact that Biggie would give shot outs to Pac and acting like he's supporting him even though he never once visited Pac in jail. This all made Pac very upset because he made Biggie. He would stop in the middle of his show to let Biggie perform, Biggie was so broke, Pac gave him money, let him sleep on his couch, and he even begged bitches to fuck Biggie. Biggie also copied Pac's Rap style, Pac had to redo his whole Me Against The World album because it sounded just like Biggies Ready To Die album. 2-Pac always said: "Biggie was Suppose to be Thug Life" but he never was.

Lil' Kim & Junior Mafia - Lil' Kim & Junior Mafia also were flat broke and Pac talked about how he always gave them money just to ride the subway home. This beef had to of started because of a dis in a song or interview, or maybe just because Biggie and Junior Mafia were good as a group.

Nas - Not sure how this beef started, but I know alot of it had to do with Pac confronted Nas and squashed his beef and Nas said the same, but then Nas's album came out and it said all this stuff about Pac on it and Nas didn't happen to mention that to Pac.

Mobb Deep - This beef started with a song they made that Pac took as a dis and about them talking about Pac which Pac felt they shouldn't have "stepped in the ring".

Jay-Z - This started because Jay-Z stuck up for Mobb Deep which make Jay-Z look like a made ass bitch.

Fugees - This one started because of a dis to Pac. They did a song together not long before Pac's death.

Da Brat - Not sure how this one started. Pac did a song with her called So So Crazy which was suppose to be on All Eyez On Me.

Dr.Dre - This started cause Dre left Death Row Records and because Dre never once showed up at Snoop's Murder trial. Pac was very loyal to Death Row Records so this made him angry. Another reason is because Dre supposedly had a gay lover who worked at Death Row.

Chino XL - Not sure how this one started. I think it had to do with Chino talking about Pac on a song or in an interview.

Wendy Williams - This beef started because she spread rumors about Pac, like Pac being raped in jail. But, I don't think Pac would let that happen cause he would beat the living shit out of them. Makaveli Style.