Porphyria Educational Services
Porphyrica Educational Services Bulletin
Vol. 2 No. 43 October 29, 2000
FOCUS: Porphyringenic chemicals and pharmaceuticals
Nearly 3,800 various chemicals in use today have been researched
and found to be porphyringenic. This is a serious problem for
many porphyria patients. Many porphyria patients, have found
themselves with a high degree of sensitivity to a large variety
of chemical toxins.
Such chemicals which are porphyringenic interefere with the human
body's ability to send oxygen to it's various parts. Such oxygen
is sent around the body through the hemoglobin which made up of
heme.
The heme in the liver is most necessary for producing the needed
cytochrome P-450.
Dr. David Flockard of Georgetown University is one of the
foremost researchers of pharmaceuticals which are cytochrome
P-450.
The Cyctochrome P-450 function in the body is most vital in the
detoxification of pharmaceuticals and other chemicals. When
porphhyria patients are exposed to drugs and chemicals which are
considered unsafe, that adversely effects the cyctochrome P-450
production. These chemicals and drugs are known as being
porphyrinogenic.
It must be noted that there are a large number of porphyrinogenic
chemicals and drugs that people are exposed to daily. Foremost
are the sulpher containing components.
Included are all of the sulfonamides and the sulfonylureas.
Another one is that of vinyl derivatrives which are found in many
of today's household and office products. Other harder to detect
substances include cyanine dyes, aldehydes, benzene derivatives,
acetylenes, aluminum, heavy metals, and a host of others.
Some of the chemicals not only produce a porphyrogenic result,
but go on to produce a porphyrin enzyme triggering defect. When
such a defect has been triggered in a porphyria patient, whether
they have inherited or acquired porphyria, such a defect can not
be reversed. With such a defect established any exposure, even a
slight amount to any of the unsafe chemicals or pharmaceuticals
can go on to exacerbate into an full blown porphyria attack.
Other chemical toxins while in themselves will not cause an
enzyme defect, will however tend to exacerbate porphyria symptoms
if a porphyrin enzyme defect is in place.
For those who frequent the highways and are caught in rush hour
traffic, especially during the winter months when exhaust fumes
tend to hang low over the roadways,
remember to close vents on your windows and have all windows
closed. Prolonged exposure to carbon monoxide in normally healthy
people can cause nausea and headaches, but for those with
porphyria enzyme defects the toll can be far greater.
JoEllen Sommerfield PhD
Professor of Biochemistry