Porphyria Educational Services
Vol. 2 No. 48 December 3, 2000
FOCUS: Hyponatremia and Porphyria
Hyponatremia deals with one part of the electrolyte imbalance
which often occurs as a part of acute attacks of porphyria.
Hyponatremia occurs when the body has less than the normal amount
of sodium in the blood. Realization of this less than normal
range of sodium is determined through a collection of blood from
a patient. Most often it is a part of the routine electrolyte
panel
which is administered as a patient is admitted to the hospital
where they will begin
intervention therapy for the porphyria.
If hyponatremia is left undiagnosed and untreated theporphyria
patient will most likely develp water intoxification. In addition
the patient will usually present with confuion and lethargy
leading to muscle spasms, convulsions and coma.
Laboratory tests to check the ranges of all electrolytes is most
essential to be administered to all porphyria patients during
acute attacks. Hyponatremia is most notable for its frequency and
intensity during acute attacks in over 50% of porphyria patients.
Increase in urinary porphobilinogen, is also often observed.
In addition septic complications, such as pneumonia, septicemia,
and urinary tract infection, present in over 50% of acute attacks
requiring hospitalization..
Administration of needed electrolytes in conjunction with the
necessary administration of carbohydrates will most often correct
the sodium levels. It is most important to followup with further
electrolyte testing as the porphyria patient begins into
remisison.
Karen Simmons, RN, NP
Intensive Care