Highlights of the January 1998 issue of Pharmaceutical Innovator

FIIs to Be Roped in for Ranbaxy's Private Placement

Lupharma to Make Public Offer to Acquire Stake in Knoll

Leakage of Hydrogen Sulphide at Max Pharma

NPPA Price Reduction Will Affect MNCs

Pharma. Research Puts Patent Loss at US $ 500 million in India

FIPB Okays Novartis' Stake Hike in Novartis India

WTO Appellate Committee: India Must Amend Patent Laws

Joint Venture Between Sarabhai and Magainin for Anti-infectives

Institutional Investors Advise Core to Sell Pharma. Business

Max-GB to Double Semi-synthetic Penicillin Capacity

Pfizer May Sell Ankleshwar Unit, Parent May Hike Stake

Novartis Plans to Launch 3 Products in India Every year

National Pharmaceutical Pricing Authority on the Prowl

New Anti-diabetic Product from Bayer

Sun's Offer on Gujarat Lyka Rejected by SEBI

Lupin Agrochemicals Renamed Cheminova India

FIPB Rejects SmithKline Offer

German Remedies to Benefit from Merger of Parent

Burnol to Reckitt, Epilex to Knoll


20101 FIIs to Be Roped in for Ranbaxy's Private Placement Reportedly, Ranbaxy's directors have hired J M Financial to privately place 7 percent of the company's equity. The directors had borrowed at high interest rates to subscribe to the warrants of their 1993 GDR issue. If the deal is finalised the company will get Rs 245 crore from the sale of 35 lakh shares. A group of 5-8 foreign institutional investors are being considered for the deal.
20102 Lupharma to Make Public Offer to Acquire Stake in Knoll Reportedly, Knoll AG's subsidiary Lupharma GmbH intends to make a public offer to acquire 11 per cent more of their holding in their Indian associate Knoll Pharmaceuticals. They already hold 40 per cent of the company. The offer price may be Rs 661 per share.

Lupharma has received SEBI exemption from making an offer for 20 per cent of the equity, as the FIPB has allowed it to hike its equity stake to 51 per cent. Thus the controlling interest will be held by Lupharma GmbH and Knoll Pharmaceuticals will be its subsidiary.


20103 Leakage of Hydrogen Sulphide at Max Pharma Four people died and seven were injured in a leakage of concentrated hydrogen Sulphide in Nanjangud plant of Max Pharma. The gas leaked when employees where clearing a choked valve in the scrubber facility. Hydrogen sulphide is a by-product in the manufacture of carbemezipine.

Following the incident the company has been issued a closure order by the Karnataka State Pollution Control Board (KSPCB). The board has instituted a committee to look into the incident, which will also suggest remedial measures to prevent further occurrences.

The KSPCB has blamed the management of the company of negligence. The scrubber is a pollution control device used to convert gases released as a by product.


20104 NPPA Price Reduction Will Affect MNCs The price reduction of 72 drug formulations by the National Pharmaceutical Pricing Authority (NPPA) will adversely affect the bottom lines of multinationals like: Glaxo, Pfizer, Hoechst, Knoll and E. Merck.

For Glaxo reduction Betnesol and Betnovate that contribute about 10.7 per cent to the company's turnover will affect its bottom line. For Knoll reduction in price of insulin, a high value product, will affect its profits. Pfizer will lose on sales of terramycin and oxytetracycline-based products. E. Merck will lose on sales of Vitamin E. The consumers, however, will benefit from the price reduction.


20105 Pharma. Research Puts Patent Loss at US $ 500 m in India Pharmaceutical Research and Manufacturers of America (PhRMA) has alleged that it is losing sales worth US $ 500 million (Rs 2,000) due to the lack of product patents in India. The World Trade Organisation (WTO) is putting pressure on India to introduce product patents, which it currently doesn't implement. The major losers are believed to be: Hoechst, Asta, Pfizer, Eli Lilly and New Medical Technology. The major countries without product patents are: Brazil, Argentina and Turkey.
20106 FIPB Okays Novartis' Stake Hike in Novartis India The FIPB has allowed Novartis AG to buy the demerged Ciba India's 9 per cent holding in Novartis India, this hiking its stake in the Indian company to above 50 per cent, a majority holding. The proposal was cleared smoothly because it was accompanied by Ciba India's clearance of the proposal.

Ciba India is a fully-owned subsidiary of Ciba Speciality Chemicals AG, formed by the demerger of Ciba-Geigy's chemical division. FIPB has also approved Novartis Nutrition AG's entry into the Indian health food segment. This company will market speciality nutrition food products including: complete foods, food supplements and planned nutrition products.

Novartis Nutrition AG has subsequently entered into a joint venture with NEPL in which Novartis will hold 49 per cent equity stake and NEPL 51 per cent stake. The new company, christened Novartis Nutrition India, is targeting middle and higher end hospitals where the products could be used in caring for patients in intensive care, cardiac care and burns care. prominent brands of the company include: Resource, Sandosource, Impact, Meritene and Vivonex.


20107 WTO Appellate Committee: India Must Amend Patent Laws The appellate committee of the World Trade Organisation (WTO) has ruled that India must amend its patent laws. The WTO has drawn up a strict deadline to introduce product patenting in India in the pharmaceutical and agricultural sectors. It must be noted that India grants only process patents and not product patents whereby internationally patented products can be manufactured in India using a different process. WTO allows an inventor 20 years to manufacture and sell a patented product. In this period the inventor and manufacturer is supposed to recover their huge investment incurred to develop a single molecule (about US $ 350 million). WTO intends to put in place a new patent regime by 2005 AD.
20108 Joint Venture Between Sarabhai and Magainin for Anti-infectives The US-based Magainin Pharmaceuticals and Ambalal Sariabhai Enterprises (ASE) is entering into an equal partnership joint venture to market and develop magainins, a new class of anti-infectives for the Indian and tropical markets.

The broad-spectrum antibiotic called cytolex will hit the market in 1999 and will be used for treating foot ulcers in diabetics. The joint venture, with head quarters in Vadodara will go on stream in the first quarter of 1998 and will use the ASE Research Centre for development and will market through the networks of ASE and Sarabhai Piramal. The Plant will manufacture mangainins for its principal's global requirements, a first for a an Indian company.


20109 Institutional Investors Advise Core to Sell Pharma. Business Institutional investors of Core Healthcare have advised it to sell off its pharmaceutical business, its captive power plant and the blood bag project to make it healthy once again. They also suggested that the directors should pledge their holdings for the rehabilitation of the company.

The company showed a loss of Rs 78 crore on sales of Rs 176 crore on capital employed of Rs 1,145 crore. Financial institutions and banks have Rs 750 crore at stake in the company, and they are worried about the downturn in the company's performance. The company has defaulted on redemption of non-convertible debentures, public deposits and interest payments to money lenders.

The company's problems started with the late implementation of the Rs 850-crore expansion and diversification programme. The rehabilitation package being organised by ICICI is not likely to stop the losses because of the huge borrowings of Rs 800 crore.


20110 Max-GB to Double Sem-synthetic Penicillin Capacity Hindustan Max-GB (HMGB - equal partnership between Hindustan Antibiotic and Max-GB) and the RPG group Searle (India) have bid for the streptomycin fermentor line of Hindustan Antibiotics. Hindustan Max already operates from the Hindustan Antibiotic campus at Pimpri in Pune.

HMGB has an agreement with the ailing Hindustan Antibiotics to run its Penicillin-G business.

Meanwhile Max-GB (equal partnership between Max (India) and GB) is set to double its capacity for semi-synthetic penicillin from 500 tpa to 1000 tpa. This is expected to trigger off a price war in a market rife with undercutting. The new capacity is expected to go on stream in the third quarter of 1998.


20111 Pfizer May Sell Ankleshwar Unit, Parent May Hike Stake Reportedly, Pfizer is selling its tablet and capsules unit at Ankleshwar and the company has appointed Arthur Andersen and BNP to find a buyer. The plant is modern with automation and technology conforming to Good Manufacturing Practice norms.

Meanwhile the American parent of Pfizer plans to increase its stake in the Indian subsidiary from 40 per cent to 51 per cent. it also intends to set up a wholly-owned research subsidiary in India. It is also in talks with Indian companies for strategic collaboration for a range of products it will bring to India after patent laws are enacted. The mode of buying the additional stake is being contemplated.


20112 Novartis Plans to Launch 3 Products in India Every Year Novartis (India's) pharmaceutical arm has plans to launch at least three commercially attractive products in India every year. The new products will be marketed under the Novartis brand name while the old products will continue to be sold under the Ciba and Sandox brand names.

World-wide Novartis has presence in 49 therapeutic segments while in India it has presence in about 33 segments. Efforts are on to make its presence felt in the balance segments. There is remarkable lack of overlap between Ciba and Sandox products and the new Novartis products are expected to be likewise.


20113 National Pharma. Pricing Authority on the Prowl The National Pharmaceutical Pricing Authority (NPPA) is sending notices to drug companies it suspects of over-pricing their products. It has already asked Rhone-Poulenc to produce data on its expectorant Phensedyl.

Section 10b of the DPCO allow full powers to the NPPA to review prices of decontrolled products in the public interest. In case of over-pricing the government may fix a price or profitability ceiling on the decontrolled products. This could lead to more products being subject to price control though the DPCO list of 74 drugs remain unchanged.

Rhone-Poulenc is expected to point to the price increase in codeine phosphate, one of the main ingredients of Phensedyl, which it buys from Government agencies. Both IDMA and OPPI have opposed the Government move.


20114 Anti-diabetic Product from Bayer Bayer (India) has launched a new oral anti-diabetic product, Glucobay, a product of its German parent. Acarbose is the active ingredient in Glucobay having microbial origins. Priced at Rs 5.50 per tablet of 50 mg, Glucobay is available in a strip of 10. The company expects sales of Rs 10 crore for the product.
20115 Sun's Offer on Gujarat Lyka Rejected by SEBI The Securities and Exchange Board of India (SEBI) has rejected an application by Sun Pharmaceutical for an exemption from making a public offer to buy 20.17 per cent stake held by an associate company in Gujarat Lyka Organics (GLO).

A final decision by SEBI is pending till early February. Sun Pharma hold 35.64 per cent stake in GLO at present. The company received approval from the centre under section 370 of the Companies Act to increase its stake. The associate company, Virtuous Finance, had acquired 20.17 per cent earlier which Sun is trying to acquire now. Sun had bought 28 per cent of Gujarat Lyka from its promoters and bought another 7 per cent subsequently through an open offer.


20116 Lupin Agro Renamed Cheminova India After its acquisition by Cheminova Agro of Denmark, Lupin Agrochemicals India will now be known as Cheminova India. It will now introduce spraying equipment from its sister company Hardi International. Cheminova also intends to introduce the pesticides dimethoate and malathion.

This fully held subsidiary is Cheminova Agro's only manufacturing plant outside Denmark and will export monocrotophos, DDVP and acephate from its Indian plant.


20117 FIPB Rejects SmithKline Offer After buying Crocin from Duphar Interfran, SmithKline Beecham plc had licensed it to its fully-owned subsidiary SmithKline Beeachm (Asia) on a royalty basis. SmithKline plc had also made an application to FIPB to infuse Pounds 5 million into SB (Asia) to develop Crocin as a global brand.

The FIPB has rejected SmithKline's offer on the basis that paracetamol on which Crocin is based is reserved for the small-scale sector. SB Asia had also made considerable investment in upgrading the packaging of Crocin tablet and had dropped plans to introduce SmithKline's international brand Panadol in India.


20118 German Remediess to Benefit from Merger of Parent Degussa's fully-owned subsidiary, Asta Medica holds a significant share in German Remedies (GR) in India. Now Degussa intends to merge with Huls, both of which are subsidiaries of Veba, a 74-billion Deutsche Mark company.

After the merger German Remedies will be part of a giant corporation and will have more funds available for research and development.

At present, Asta holds 11.5 per cent of German Remedies with the other shareholders being: Heller, Becham, Schering and Boehringer Ingelheim.

GR's main brand is Asta's Derifylline, Kamillosan (a herbal cream), Honvan (a prostatic cancer drug), Azelastine (an anti-histamine)


.

20119 Burnol to Reckitt, Epilex to Knoll Knoll Pharmaceuticals, after selling Burnol and Coldarin recently has turned buyer, buying Epilex, an anti-epilepsy product from Reckitt India. Reckitt India is concentrating on over-the-counter products and Epilex is its last ethical product.

Reportedly, the price paid for Epilex is approximately twice its ORG sales of Rs 5.1 crore. Knoll's rationale in buying the product is that it has another product - Eptoin - in the same category.

After selling Burnol to Reckitt Piramal, Knoll has acquired Epilex from Reckitt India.