Coffee with antioxidants
Topic: Health
This is good news for coffee-lovers.

In its report entitled "Another Coffee Perk: Antioxidants", HealthCentral.com says:

By measuring the amount of antioxidants contained in the most common foods and beverages, and comparing them to U.S. government data on food consumption, researchers found that coffee far outpaced any other beverage or food as the main source of antioxidants in the American diet.

... [T]he average American received more than four times the amount of antioxidants from coffee daily than from black tea, which was second on the list. Bananas, dry beans and corn were the top three foods on the list.

However, Joe Vinson, the University of Scranton chemist who presented the results of his analysis yesterday at the annual meeting of the American Chemical Society, in Washington, DC, was also quoted in the report as saying that coffee has been linked to increased risk of cardiovascular disease and high blood pressure.

So the recommendation in mainstream health circles to rely more on fruits and vegetables for antioxidants still seems to be the more prudent one.

American interest in Chinese rises with China's rising economic power
Topic: Society
AFP had a story recently entitled "China's rapid rise spurs Americans to learn Chinese". An excerpt:

China is casting such a huge shadow on the United States that many Americans are scrambling to learn the Chinese language in a bid to retain their competitive edge.

"Interest in learning Chinese among American youth and their parents has grown dramatically in the past five years," said Vivien Stewart, vice president at the Asia Society, a US group trying to bridge the gap between Americans and the peoples of Asia and the Pacific.

China's dramatic rise to near superpower status and its telling effects politically, economically and culturally are driving the interest to learn the language, experts say.

The report also mentioned the following:

[In US schools] Japanese is the most-sought-after Asian language.

"Our nation's schools are locked in a time warp," said Charles E.M. Kolb, president of the Committee for Economic Development, a pro-business think tank in Washington. "By ignoring critical languages such as Chinese and the essential cultural knowledge needed to succeed, our school systems are out of step with new global realities," he said.

I have been struck for some time by how ordinary Americans seem to know much more about Japanese culture and history than about Chinese culture and history, despite the fact that the latter are obviously richer. Clearly, Japan's economic power counts here. Cultural power comes from economic power.

However, as Mr Kolb said, there are new global realities, and Americans have to learn to adjust to them or find themselves at an increasing disadvantage in the global political and economic spheres.

Exercise cannot halt age-related effects on fitness
Topic: Health
A new study published in the American Heart Association journal Circulation shows that exercise cannot ward off the effects of ageing. Excerpt from the Associated Press report.

A treadmill test given to different age groups showed that as people aged, their aerobic capacity -- the amount of oxygen consumed while exercising -- declined at higher rates with each passing decade whether they exercised or not.

The researchers knew the rate of decline would worsen with age, but they were surprised by the magnitude, said Dr. Jerome L. Fleg, a cardiologist who is lead author of the study and a medical officer at the National Heart, Lung and Blood Institute in Maryland.

"I guess we were a little disappointed that regular exercise didn't make a difference in the rate of decline," he said.

However, he pointed out that those who exercise still end up ahead because their aerobic capacity was higher to begin with.

"If I start higher, I'm going to end higher," Fleg said. "Having a higher aerobic capacity translates into being more fit."

In my opinion, there is too much hope and hype involved in exercise. As the report points out, exercise can improve a person's health and fitness, but the deterioration in the body associated with ageing is an intrinsic process. It affects the body at a cellular and even genetic level -- see, for example, my previous posts on telomeres and ageing "Stress and ageing" and "Obesity and smoking affect biological age". While exercise causes the body to adapt closer to its capacity -- that is, it causes the body to become fitter -- that capacity -- the maximum fitness that the body can attain -- itself declines with age.

The idea in some that exercise can arrest or reverse that age-related decline in fitness capacity was always a bit of wishful thinking.

Obesity and smoking affect biological age
Topic: Health
A new study has provided yet more evidence that telomeres play a fundamental role in translating risk factors into age-related diseases.

Telomeres are the material which cap the ends of the chromosomes in cells and protect them from damage. Every time a cell divides -- and as people age -- the telomeres get shorter.

The new study involved more than 1,100 British women aged between 18 and 76 years. The women filled out a questionnaire on their smoking history and provided blood samples, which were tested for concentrations of a body fat regulator called leptin and for telomere length.

As HealthDay News reports, the study found that:

...telomeres of obese women and smokers were much shorter than those of lean women and those who'd never smoked. In contrast, lean women had much longer telomeres than moderately overweight women who, in turn, had longer telomeres than obese women.

The net effects:

Overall, obese women aged an additional 8.8 years -- based on telomere length -- compared to lean women, the researchers reported. A current or previous history of smoking entailed an average 4.6 year increase in aging compared to never-smokers, while those with long-term smoking habits -- a pack-a-day for 40 years -- added an additional 7.4 years of aging to their life compared to those who stayed away from cigarettes completely, the study found.

For another post on research involving telomeres, see "Stress and ageing".

The biology of psychopathy and empathy
Topic: Science & Technology
Researchers have found that psychopathy may be an inherited trait.

An article in The Economist "Original sinners?" reported the results of a study on twins' behaviour. Many of the twins studied had a tendency to bad behaviour and for the display of callous and unemotional traits, such as a lack of feelings of guilt after doing something wrong, or not having at least one good friend. In adults, callous and unemotional traits are symptoms of psychopathy.

The findings were reported as follows:

Based on the teachers' assessments, the researchers identified the naughtiest 10% of the individuals in their sample—in other words those with severe conduct disorder. They then subdivided these children into those with psychopathic traits and those without and asked, in each case, whether an individual's twin showed bad behaviour, psychopathy, or both.

Their analysis showed that bad behaviour without psychopathy has relatively little genetic component—less than a third. By contrast, four-fifths of the difference in behaviour between the general population and children with psychopathic traits seems to lie in the genes.

The article concluded that if there is a genetic basis for psychopathy, there is probably a selective advantage to the trait.

If it does, such an advantage probably pertains only when psychopaths are in the minority (a state of affairs known to biologists as a balanced polymorphism). But it does mean that far from being an aberrant behaviour, psychopathy may be disturbingly normal.

Callous and emotional traits are related to empathy, or more accurately, the lack of it. An earlier article in The Economist "A mirror to the world" discussed the biological basis of empathy.

Essentially, empathy appears to rely on a type of nerve cell known as a mirror neuron. A mirror neuron is one that is active when the individual whose brain it is in is engaged in some action or experiencing some sensation or emotion, and also when that particular action, sensation or emotion is being observed in someone else. A lack of mirror-neuron activity is considered to be at least part of the cause of autism.

The idea that traits such as empathy and psychopathy have biological and even genetic bases will inevitably be controversial to society, as most claims of genetic linkages in personality traits tend to be. However, it is the job of scientists to discover the science behind the traits, and the responsibility of society as a whole to determine what to do with the discoveries.

Innovation and age
Topic: Science & Technology
Edward Hugh reads a working paper "Age and Great Invention" from the National Bureau of Economic Research and concludes that "there is hope for some of us yet". From the abstract of the paper:

Great achievements in knowledge are produced by older innovators today than they were a century ago... I find that innovators are much less productive at younger ages, beginning to produce major ideas 8 years later at the end of the 20th Century than they did at the beginning. Furthermore, the later start to the career is not compensated for by increasing productivity beyond early middle age... [T]he accumulation of knowledge across generations leads innovators to seek more education over time. More generally, the results show that individual innovators are productive over a narrowing span of their life cycle, a trend that reduces -- other things equal -- the aggregate output of innovators. This drop in productivity is particularly acute if innovators' raw ability is greatest when young.

Yes, there is reason to be hopeful for some -- specifically for those who might have thought they had missed the innovation boat -- but overall, the message of a narrowing productive innovation life span is not one of optimism.

On the other hand, greater knowledge accumulation through longer education means that innovators start the most productive phase of their life spans with greater innovative capacity. In addition, the information and management sciences now have a better understanding of how information is assimilated and converted into knowledge and thence, innovation.

Improvements arising from such understanding enable organisations and individual innovators to compensate for the shorter innovation life spans of the latter with more intensively productive ones.

Diet affects recurrence of breast cancer
Topic: Health
A new study has found that postmenopausal breast cancer survivors who cut down on fats in their diet can reduce their risk of tumor recurrence.

WebMD reports the following details on the study:

The study included 2,437 women aged 48 to 75. All were treated with surgery for breast cancer, followed by radiation, chemotherapy, and hormone treatment, if needed. Every three months, they received some general dietary guidance.

Nearly 1,000 of the women were also entered into an intensive nutrition program... Women who received the intensive counseling reduced the amount of fat in their diet from 51 grams per day to about 33 grams a day, or from 29% to 21% of their total daily calories.

And the results:

At five years, less than 10% of those on the low-fat diet had their cancer recur. Twelve percent of the women who continued on their usual diet had cancer recurrence during this time. This translates to about a 24% reduction in risk, [researcher Rowan T] Chlebowski says.

Most breast cancers are fueled by estrogen, and because of this several treatments are available that block hormones to the breast and reduce the risk of recurrence.

Women whose tumors were not fueled by hormones -- a high-risk group that account for about 30% of women with breast cancer -- benefited the most. Their chances of recurrence fell by about 42% when limiting dietary fats.

This study just adds to the growing body of evidence that diet has an important role in the incidence of cancer. There are two caveats, though.

First of all, although the women on the low-fat diet benefited as a group, the researchers are not clear on whether the benefit was derived from the low amount of fat consumed or from other factors -- for example, weight loss, increase in fibre consumption.

Secondly, for the study subjects a whole -- as opposed to just those women whose tumours were not fueled by hormones -- the recurrence rate dropped from 12 percent for those on their usual diet to 10 percent for those on the low-fat diet -- all of 2 percentage points.

More studies on this would certainly be helpful.

Vitamin D, calcium supplements not helpful in osteoporosis
Topic: Health
Two new studies carried out in the United Kingdom have found that taking vitamin D or calcium supplements does not help prevent fractures in elderly people.

In one study, researchers led by University of Aberdeen professor Adrian Grant randomly assigned 5,292 people over 70 who had already suffered a fracture either to take a dummy pill, a daily supplement of vitamin D, calcium or both supplements together. They were then tracked for between 24 and 62 months.

The researchers found that 13 percent of the patients had a new fracture. For people in the group taking calcium, the fracture rate was 12.6 percent, compared with 13.7 percent of those taking a dummy pill. For those taking vitamin D alone, the fracture rate was 13.3 percent, compared with 13.1 percent for those taking the dummy pill. And for those taking both calcium and vitamin D, the fracture rate was 12.6 percent, compared with 13.4 percent for those taking the dummy pill.

The researchers concluded that supplements do not offer protection from second fractures.

This study appears in the April 27 online issue of The Lancet.

In the second study at the University of York, researchers tracked 3,314 women aged 70 and older. Half were given calcium and vitamin D tablets to take daily, the rest just received a leaflet on diet and prevention of falls. All women were monitored for an average of about two years.

The researchers found that about 1 percent of women in both groups suffered a subsequent hip fracture. The researchers concluded that there was no reduction in hip fractures with either calcium or vitamin D.

This study appears in the April 30 issue of the British Medical Journal.

An expert interviewed by HealthDay saw nothing new in The Lancet study. "I am not surprised," said Dr. Steven J. Goldstein, a professor of obstetrics and gynecology at New York University Medical Center. "By definition, the people they studied here had osteoporosis."

"We know that vitamin D and calcium alone are not sufficient to treat osteoporosis," Goldstein added. "All this study showed is that if you take people who have already suffered a fracture, who therefore by definition have osteoporosis, and you simply treat them with calcium and vitamin D, it's not sufficient. You've already let the horse out of the barn."

Goldstein pointed out that the time to take vitamin D and calcium is when you are young.

Obesity and mortality
Topic: Health
A new study has found that obesity is not as dangerous as previously thought.

Researchers from Centers for Disease Control and Prevention (CDC) have found that both obesity and being underweight are associated with excess deaths when compared with the normal weight population.

There were 112,000 more deaths than expected among obese individuals, that is, those with body mass index (BMI) of 30 or higher. Among underweight individuals -- those with BMI of less than 18.5 -- there were nearly 34,000 more deaths than expected. However, while most of the excess deaths among the underweight occurred in people age 70 or older, most of the excess deaths among the obese occurred in people younger than 70.

Being slightly overweight -- BMI of 25-29.9 -- was not associated with excess mortality. In fact, the study found 87,000 fewer deaths than expected among those in this BMI range.

Another study by researchers from CDC found that cardiovascular disease risk factors in the US have declined, regardless of BMI. The exception was diabetes, which has increased by 55 percent over the past 40 years.

These studies appear in the 20 April 2005 issue of Journal of the American Medical Association (JAMA).

Most reports on the study linking obesity and mortality have highlighted the fact that it shows that the risk of death from being overweight has been overestimated. Times Online, however, entitled its report on the study "If you want to live longer - put on weight". This seems unwarranted.

First of all, whether putting on weight is healthy depends on your starting weight. Obesity is still associated with higher death risk.

Secondly, it may be premature to make recommendations based on this study. No one study can be conclusive. The findings need to be replicated in other studies to eliminate the possibility of flaws in the study. With so many factors affecting health and mortality rates, failure to properly account for any factor can have an impact on the overall result. After all, CDC itself had earlier put out a report that predicted a much higher mortality rate from obesity, which, in the light of the findings from the new study, is leading to some controversy in the United States (see the report "Stonewalling: Why Won’t The CDC Endorse New Obesity Deaths Figure?")

In any case, as the Times Online itself wrote, quoting Nigel Hawkes, The Times health editor: "Despite its breadth, the conclusions of the report are limited. It looked only at deaths, not at disease or disability which generally increase with weight".

Happiness brings health
Topic: Health
A new study has found that happiness may bring health.

Researchers from University College London tested 116 men and 100 women who were taking part in a major study of thousands of London-based civil servants to investigate the risk factors for coronary heart disease. The researchers evaluated the level of happiness of the subjects during the course of the day.

The researchers found that levels of cortisol -- a stress hormone related to conditions including type II diabetes and high blood pressure -- were 32 percent lower in people who reported more happy moments. Happy people also had lower levels of plasma fibrinogen -- a marker for inflammation and an indication of heart disease -- when they were stressed.

The research is published in the Proceedings of the National Academy of Sciences. The BBC and WebMD carry reports on the study.

By focusing on happiness, this study complements some others that find that psychological distress adversely affects health -- see for example "Stress and ageing".