What are Autoimmune Diseases?
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word "auto" is the Greek word for self. The immune system is a
complicated network of cells and cell components (called molecules) that
normally work to defend the body and eliminate infections caused by bacteria,
viruses, and other invading microbes. If a person has an autoimmune disease, the
immune system mistakenly attacks self, targeting the cells, tissues, and organs
of a person's own body. A collection of immune system cells and molecules at a
target site is broadly referred to as inflammation.
There are many different autoimmune diseases, and they can each affect the body
in different ways. For example, the autoimmune reaction is directed against the
brain in multiple sclerosis and the gut in Crohn's disease. In other autoimmune
diseases such as systemic lupus erythematosus (lupus), affected tissues and
organs may vary among individuals with the same disease. One person with lupus
may have affected skin and joints whereas another may have affected skin,
kidney, and lungs. Ultimately, damage to certain tissues by the immune system
may be permanent, as with destruction of insulin-producing cells of the pancreas
in Type 1 diabetes mellitus.
Who Is Affected by Autoimmune Diseases?
Many of the autoimmune diseases are rare. As a group, however, autoimmune
diseases afflict millions of Americans. Most autoimmune diseases strike women
more often than men; in particular, they affect women of working age and during
their childbearing years.
Some autoimmune diseases occur more frequently in certain minority populations.
For example, lupus is more common in African-American and Hispanic women than in
Caucasian women of European ancestry. Rheumatoid arthritis and scleroderma
affect a higher percentage of residents in some Native American communities than
in the general U.S. population. Thus, the social, economic, and health impact
from autoimmune diseases is far-reaching and extends not only to family but also
to employers, co-workers, and friends.
What Are the Causes of Autoimmune Diseases?
Are they contagious? No autoimmune disease has ever been shown to be contagious
or "catching." Autoimmune diseases do not spread to other people like
infections. They are not related to AIDS, nor are they a type of cancer.
Are they inherited? The genes people inherit contribute to their susceptibility
for developing an autoimmune disease. Certain diseases such as psoriasis can
occur among several members of the same family. This suggests that a specific
gene or set of genes predisposes a family member to psoriasis. In addition,
individual family members with autoimmune diseases may inherit and share a set
of abnormal genes, although they may develop different autoimmune diseases. For
example, one first cousin may have lupus, another may have dermatomyositis, and
one of their mothers may have rheumatoid arthritis.
The development of an autoimmune disease may be influenced by the genes a person
inherits together with the way the person's immune system responds to certain
triggers or environmental influences.
What other factors may influence the development of autoimmune diseases? Some
autoimmune diseases are known to begin or worsen with certain triggers such as
viral infections. Sunlight not only acts as a trigger for lupus but can worsen
the course of the disease. It is important to be aware of the factors that can
be avoided to help prevent or minimize the amount of damage from the autoimmune
disease. Other less understood influences affecting the immune system and the
course of autoimmune diseases include aging, chronic stress, hormones, and
How Does the Immune System Work?
The immune system defends the body from attack by invaders recognized as
foreign. It is an extraordinarily complex system that relies on an elaborate and
dynamic communications network that exists among the many different kinds of
immune system cells that patrol the body. At the heart of the system is the
ability to recognize and respond to substances called antigens whether they are
infectious agents or part of the body (self antigens).
T and B Cells
Most immune system cells are white blood cells, of which there are many types.
Lymphocytes are one type of white blood cell, and two major classes of
lymphocytes are T cells and B cells. T cells are critical immune system cells
that help to destroy infected cells and coordinate the overall immune response.
The T cell has a molecule on its surface called the T-cell receptor. This
receptor interacts with molecules called MHC (major histocompatibility complex).
MHC molecules are on the surfaces of most other cells of the body and help T
cells recognize antigen fragments. B cells are best known for making antibodies.
An antibody binds to an antigen and marks the antigen for destruction by other
immune system cells. Other types of white blood cells include macrophages and
Macrophages and Neutrophils
Macrophages and neutrophils circulate in the blood and survey the body for
foreign substances. When they find foreign antigens, such as bacteria, they
engulf and destroy them. Macrophages and neutrophils destroy foreign antigens by
making toxic molecules such as reactive oxygen intermediate molecules. If
production of these toxic molecules continues unchecked, not only are the
foreign antigens destroyed, but tissues surrounding the macrophages and
neutrophils are also destroyed. For example, in individuals with the autoimmune
disease called Wegener's granulomatosis, overactive macrophages and neutrophils
that invade blood vessels produce many toxic molecules and contribute to damage
of the blood vessels. In rheumatoid arthritis, reactive oxygen intermediate
molecules and other toxic molecules are made by overproductive macrophages and
neutrophils invading the joints. The toxic molecules contribute to inflammation,
which is observed as warmth and swelling, and participate in !
damage to the joint.
MHC and Co-Stimulatory Molecules
MHC molecules are found on all cell surfaces and are an active part of the
body's defense team. For example, when a virus infects a cell, a MHC molecule
binds to a piece of a virus (antigen) and displays the antigen on the cell's
surface. Cells that have the capability of displaying antigen with MHC are
called antigen-presenting cells. Each MHC molecule that displays an antigen is
recognized by a matching or compatible T-cell receptor. Thus, an
antigen-presenting cell is able to communicate with a T cell about what may be
occurring inside the cell. However, for the T cell to respond to a foreign
antigen on the MHC, another molecule on the antigen-presenting cell must send a
second signal to the T cell. A corresponding molecule on the surface of the T
cells recognizes the second signal. These two secondary molecules of the
antigen-presenting cell and the T cell are called co-stimulatory molecules.
There are several different sets of co-stimulatory molecules that can participa!
te in the interaction of antigen-presenting cell with a T cell.
Once the MHC and the T-cell receptor interact, and the co-stimulatory molecules
interact, there are several possible paths that the T cell may take. These
include T cell activation, tolerance, or T cell death. The subsequent steps
depend in part on which co-stimulatory molecules interact and how well they
interact. Because these interactions are so critical to the response of the
immune system, researchers are intensively studying them to find new therapies
that could control or stop the immune system attack on self tissues and organs.
Cytokines and Chemokines
One way T cells can respond after the interaction of the MHC and the T-cell
receptor, and the interaction of the co-stimulatory molecules, is to secrete
cytokines and chemokines. Cytokines are proteins that may cause surrounding
immune system cells to become activated, grow, or die. They also may influence
non-immune system tissues. For example, some cytokines may contribute to the
thickening of the skin that occurs in people with scleroderma.
Chemokines are small cytokine molecules that attract cells of the immune system.
Overproduction of chemokines contributes to the invasion and inflammation of the
target organ, which occurs in autoimmune diseases. For example, overproduction
of chemokines in the joints of people with rheumatoid arthritis may result in
invasion of the joint space by destructive immune system cells such as
macrophages, neutrophils, and T cells.
B cells are another critical type of immune system cell. They participate in the
removal of foreign antigens from the body by using a surface molecule to bind
the antigen or by making specific antibodies that can search out and destroy
specific foreign antigens. However, the B cell can only make antibodies when it
receives the appropriate command signal from a T cell. Once the T cell signals
the B cell with a type of cytokine that acts as a messenger molecule, the B cell
is able to produce a unique antibody that targets a particular antigen.
In some autoimmune diseases, B cells mistakenly make antibodies against tissues
of the body (self antigens) instead of foreign antigens. Occasionally, these
autoantibodies either interfere with the normal function of the tissues or
initiate destruction of the tissues. People with myasthenia gravis experience
muscle weakness because autoantibodies attack a part of the nerve that
stimulates muscle movement. In the skin disease pemphigus vulgaris,
autoantibodies are misdirected against cells in the skin. The accumulation of
antibodies in the skin activates other molecules and cells to break down,
resulting in skin blisters.
Immune Complexes and the Complement System
When many antibodies are bound to antigens in the bloodstream, they form a large
lattice network called an immune complex. Immune complexes are harmful when they
accumulate and initiate inflammation within small blood vessels that nourish
tissues. Immune complexes, immune cells, and inflammatory molecules can block
blood flow and ultimately destroy organs such as the kidney. This can occur in
people with systemic lupus erythematosus.
A group of specialized molecules that form the complement system helps to remove
immune complexes. The different types of molecules of the complement system,
which are found in the bloodstream and on the surfaces of cells, make immune
complexes more soluble. Complement molecules prevent formation and reduce the
size of immune complexes so they do not accumulate in the wrong places (organs
and tissues of the body). Rarely, some people inherit defective genes for a
complement molecule from their parents. Because these individuals cannot make a
normal amount or type of complement molecule, their immune systems are unable to
prevent immune complexes from being deposited in different tissues and organs.
These people develop a disease that is not autoimmune but resembles lupus
Genetic factors can affect an individual's immune system and its responses to
foreign antigens in several ways. Genes determine the variety of MHC molecules
that individuals carry on their cells. Genes also influence the potential array
of T-cell receptors present on T cells. In fact, some MHC genes are associated
with autoimmune diseases. However, genes are not the only factors involved in
determining a person's susceptibility to an autoimmune disease. For example,
some individuals who carry disease-associated MHC molecules on their cells will
not develop an autoimmune disease.
How Are Autoimmune Diseases Diagnosed?
The diagnosis of an autoimmune disease is based on an individual's symptoms,
findings from a physical examination, and results from laboratory tests.
Autoimmune diseases can be difficult to diagnose, particularly early in the
course of the disease. Symptoms of many autoimmune diseases (such as fatigue)
are nonspecific. Laboratory test results may help but are often inadequate to
confirm a diagnosis.
If an individual has skeletal symptoms such as joint pain and a positive but
nonspecific lab test, she or he may be diagnosed with the confusing name of
early or "undifferentiated" connective tissue disease. In this case, a
physician may want the patient to return frequently for follow up. The early
phase of disease may be a very frustrating time for both the patient and
physician. On the other hand, symptoms may be short-lived, and inconclusive
laboratory tests may amount to nothing of a serious nature.
In some cases, a specific diagnosis can be made. A diagnosis shortly after onset
of a patient's symptoms will allow for early aggressive medical therapy; and for
some diseases, patients will respond completely to treatments if the reason for
their symptoms is discovered early in the course of their disease.
Although autoimmune diseases are chronic, the course they take is unpredictable.
A doctor cannot foresee what will happen to the patient based on how the disease
starts. Patients should be monitored closely by their doctors so environmental
factors or triggers that may worsen the disease can be discussed and avoided and
new medical therapy can be started as soon as possible. Frequent visits to a
doctor are important in order for the physician to manage complex treatment
regimens and watch for medication side effects.
How Are Autoimmune Diseases Treated?
Autoimmune diseases are often chronic, requiring lifelong care and monitoring,
even when the person may look or feel well. Currently, few autoimmune diseases
can be cured or made to "disappear" with treatment. However, many
people with these diseases can live normal lives when they receive appropriate
Physicians most often help patients manage the consequences of inflammation
caused by the autoimmune disease. For example, in people with Type 1 diabetes,
physicians prescribe insulin to control blood sugar levels so that elevated
blood sugar will not damage the kidneys, eyes, blood vessels, and nerves.
However, the goal of scientific research is to prevent inflammation from causing
destruction of the insulin-producing cells of the pancreas, which are necessary
to control blood sugars.
On the other hand, in some diseases such as lupus or rheumatoid arthritis,
medication can occasionally slow or stop the immune system's destruction of the
kidneys or joints. Medications or therapies that slow or suppress the immune
system response in an attempt to stop the inflammation involved in the
autoimmune attack are called immunosuppressive medications. These drugs include
corticosteroids (prednisone), methotrexate, cyclophosphamide, azathioprine, and
cyclosporin. Unfortunately, these medications also suppress the ability of the
immune system to fight infection and have other potentially serious side
In some people, a limited number of immuno-suppressive medications may result in
disease remission. Remission is the medical term used for
"disappearance" of a disease for a significant amount of time. Even if
their disease goes into remission, patients are rarely able to discontinue
medications. The possibility that the disease may restart when medication is
discontinued must be balanced with the long-term side effects from the
A current goal in caring for patients with autoimmune diseases is to find
treatments that produce remissions with fewer side effects. Much research is
focused on developing therapies that target various steps in the immune
response. New approaches such as therapeutic antibodies against specific T cell
molecules may produce fewer long-term side effects than the chemotherapies that
now are routinely used.
Ultimately, medical science is striving to design therapies that prevent
autoimmune diseases. To this end, a significant amount of time and resources are
spent studying the immune system and pathways of inflammation.
What Are Some Examples of Autoimmune Diseases?
In people with rheumatoid arthritis, the immune system predominantly targets the
lining (synovium) that covers various joints. Inflammation of the synovium is
usually symmetrical (occurring equally on both sides of the body) and causes
pain, swelling, and stiffness of the joints. These features distinguish
rheumatoid arthritis from osteoarthritis, which is a more common and
degenerative "wear-and-tear" arthritis.
Currently available therapy focuses on reducing inflammation of the joints with
anti-inflammatory or immunosuppresssive medications. Sometimes, the immune
system may also target the lung, blood vessels, or eye; occasionally patients
may also develop symptoms of other autoimmune diseases such as Sjogren's the
inflammation, itching, and scaling. For more severe cases, oral medications are
used. Psoriasis is common and may affect more than 2 out of 100 Americans.
Psoriasis often runs in families.
Multiple sclerosis is a disease in which the immune system targets nerve tissues
of the central nervous system. Most commonly, damage to the central nervous
system occurs intermittently, allowing a person to lead a fairly normal life. At
the other extreme, the symptoms may become constant, resulting in a progressive
disease with possible blindness, paralysis, and premature death. Some
medications such as beta interferon are helpful to people with the intermittent
form of multiple sclerosis.
In young adults, multiple sclerosis is the most common disabling disease of the
nervous system. Multiple sclerosis afflicts 1 in 700 people in this country.
Researchers continue to search for triggers of the disease.
Immune-Mediated or Type 1 Diabetes Mellitus
Type 1 diabetes mellitus results from autoimmune destruction of the
insulin-producing cells of the pancreas. Insulin is required by the body to keep
the blood sugar (glucose) level under control. High levels of glucose are
responsible for the symptoms and the complications of the disease. However, most
of the insulin-producing cells are destroyed before the patient develops
symptoms of diabetes. Symptoms include fatigue, frequent urination, increased
thirst, and possible sudden confusion.
Type 1 diabetes mellitus is usually diagnosed before the age of 30 and may be
diagnosed as early as the first month of life. Together with Type 2 diabetes
(not considered an autoimmune disease), diabetes mellitus is the leading cause
of kidney damage, loss of eyesight, and leg amputation. Close control of sugar
levels decreases the rate at which these events occur. There is a genetic
predisposition to Type 1 diabetes, which occurs in 1 out of 800 people in the
United States. Among individuals who have a close relative with Type 1 diabetes,
those at high risk for developing disease can be identified. Efforts are now
under way to evaluate prevention strategies for these family members at risk.
Inflammatory Bowel Diseases
This medical term is used for both Crohn's disease and ulcerative colitis, two
diseases in which the immune system attacks the gut (intestine). Patients may
have diarrhea, nausea, vomiting, abdominal cramps, and pain that can be
difficult to control. Illness in afflicted individuals can result from
intestinal inflammation and from side effects of the drugs used for the disease.
For example, daily use of high-dose corticosteroid (prednisone) therapy, which
is needed to control severe symptoms of Crohn's disease, can predispose patients
to infections, bone thinning (osteoporosis), and fractures. For patients with
ulcerative colitis, surgical removal of the lower intestine (colon) will
eliminate the disease and their increased risk for colon cancer. More than 1 in
500 Americans has some type of inflammatory bowel disease.
Systemic Lupus Erythematosus
Patients with systemic lupus erythematosus most commonly experience profound
fatigue, rashes, and joint pains. In severe cases, the immune system may attack
and damage several organs such as the kidney, brain, or lung. For many
individuals, symptoms and damage from the disease can be controlled with
available anti-inflammatory medications. However, if a patient is not closely
monitored, the side effects from the medications can be quite serious. Lupus
occurs in 1 out of 2,000 Americans and in as many as 1 in 250 young,
Psoriasis is an immune system disorder that affects the skin, and occasionally
the eyes, nails, and joints. Psoriasis may affect very small areas of skin or
cover the entire body with a buildup of red scales called plaques. The plaques
are of different sizes, shapes, and severity and may be painful as well as
unattractive. Bacterial infections and pressure or trauma to the skin can
aggravate psoriasis. Most treatments focus on topical skin care to relieve the
inflammation, itching, and scaling. For more severe cases, oral medications are
used. Psoriasis is common and may affect more than 2 out of 100 Americans.
Psoriasis often runs in families.
This autoimmune disease results in thickening of the skin and blood vessels.
Almost every patient with scleroderma has Raynaud's, which is a spasm of the
blood vessels of the fingers and toes. Symptoms of Raynaud's include increased
sensitivity of the fingers and toes to the cold, changes in skin color, pain,
and occasionally ulcers of the fingertips or toes. In people with scleroderma,
thickening of skin and blood vessels can result in loss of movement and
shortness of breath or, more rarely, in kidney, heart, or lung failure. The
estimated number of people with any type of scleroderma varies from study to
study but may range from 1 to 4 affected individuals for every 10,000 Americans
(or as many as 1 out of 2500 individuals).
Autoimmune Thyroid Diseases
Hashimoto's thyroiditis and Grave's disease result from immune system
destruction or stimulation of thyroid tissue. Symptoms of low (hypo-) or
overactive (hyper-) thyroid function are nonspecific and can develop slowly or
suddenly; these include fatigue, nervousness, cold or heat intolerance,
weakness, changes in hair texture or amount, and weight gain or loss. The
diagnosis of thyroid disease is readily made with appropriate laboratory tests.
The symptoms of hypothyroidism are controlled with replacement thyroid hormone
pills; however, complications from over- or under-replacement of the hormone can
occur. Treatment of hyperthyroidism requires long-term anti-thyroid drug therapy
or destruction of the thyroid gland with radioactive iodine or surgery. Both of
these treatment approaches carry certain risks and long-term side effects.
Autoimmune thyroid diseases afflict as many as 4 out of 100 women and are
frequently found in families where there are other autoimmune diseases.
From the NIH/NIAID:
Understanding Autoimmune Diseases
For the complete article see:
This page was last updated on 03/16/2005
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